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    Tmtc2 transmembrane and tetratricopeptide repeat containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 278279, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmtc2provided by MGI
    Official Full Name
    transmembrane and tetratricopeptide repeat containing 2provided by MGI
    Primary source
    MGI:MGI:1914057
    See related
    Ensembl:ENSMUSG00000036019 AllianceGenome:MGI:1914057
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    8430438D04Rik; D330034A10Rik
    Summary
    Predicted to enable dolichyl-phosphate-mannose-protein mannosyltransferase activity. Predicted to be involved in calcium ion homeostasis and protein O-linked mannosylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including cranial ganglion; gut; limb segment; musculoskeletal system; and sensory organ. Orthologous to human TMTC2 (transmembrane O-mannosyltransferase targeting cadherins 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in limb E14.5 (RPKM 7.3), lung adult (RPKM 5.4) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Tmtc2 in Genome Data Viewer
    Location:
    10 D1; 10 54.72 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (105023524..105410340, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (105187663..105574479, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40753 Neighboring gene predicted gene, 25422 Neighboring gene predicted gene, 46241 Neighboring gene keratin 19 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr10:105012433-105012734 Neighboring gene predicted gene 15663 Neighboring gene STARR-seq mESC enhancer starr_27763 Neighboring gene STARR-seq mESC enhancer starr_27765 Neighboring gene methyltransferase like 25 Neighboring gene STARR-positive B cell enhancer ABC_E9803

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Clone Names

    • MGC116613

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein O-linked mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein O-linked mannosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein O-linked mannosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    protein O-mannosyl-transferase TMTC2
    Names
    transmembrane O-mannosyltransferase targeting cadherins 2
    transmembrane and TPR repeat-containing protein 2
    NP_796342.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177368.4NP_796342.2  protein O-mannosyl-transferase TMTC2 precursor

      See identical proteins and their annotated locations for NP_796342.2

      Status: VALIDATED

      Source sequence(s)
      AK052344, BB652678, BC092226
      Consensus CDS
      CCDS24157.1
      UniProtKB/Swiss-Prot
      B2RRD8, Q56A06, Q5U620, Q8C787
      Related
      ENSMUSP00000061919.9, ENSMUST00000061506.9
      Conserved Domains (8) summary
      sd00006
      Location:527555
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:779812
      TPR_1; Tetratricopeptide repeat
      pfam07719
      Location:609639
      TPR_2; Tetratricopeptide repeat
      pfam08409
      Location:247321
      DUF1736; Domain of unknown function (DUF1736)
      pfam12895
      Location:618703
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3
      pfam13414
      Location:493554
      TPR_11; TPR repeat
      pfam13424
      Location:557634
      TPR_12; Tetratricopeptide repeat
      pfam14559
      Location:755822
      TPR_19; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      105023524..105410340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004936193.1 RNA Sequence

    2. XR_004936194.1 RNA Sequence

    3. XR_004936195.1 RNA Sequence

    4. XR_380404.4 RNA Sequence