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    Ubox5 U box domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 140629, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ubox5provided by MGI
    Official Full Name
    U box domain containing 5provided by MGI
    Primary source
    MGI:MGI:2154658
    See related
    Ensembl:ENSMUSG00000027300 AllianceGenome:MGI:2154658
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UIP5; Rnf37; Ube7ip5; Ubce7ip5; 1500010O06Rik; C330018L13Rik
    Summary
    Enables ubiquitin protein ligase binding activity and ubiquitin-ubiquitin ligase activity. Acts upstream of or within protein polyubiquitination. Located in nucleus. Is expressed in central nervous system and genitourinary system. Orthologous to human UBOX5 (U-box domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 3.3), CNS E11.5 (RPKM 2.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ubox5 in Genome Data Viewer
    Location:
    2 F1; 2 63.24 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130431916..130471958, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (130589996..130630038, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene oxytocin Neighboring gene arginine vasopressin Neighboring gene FAST kinase domains 5 Neighboring gene STARR-positive B cell enhancer ABC_E5982 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:130461487-130461688 Neighboring gene leucine zipper, putative tumor suppressor family member 3 Neighboring gene DDRGK domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E10144

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes. Pringa E, et al. J Biol Chem, 2001 Jun 1. PMID 11274149
    2. A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. Martinez-Noel G, et al. FEBS Lett, 1999 Jul 9. PMID 10431818
    3. U box proteins as a new family of ubiquitin-protein ligases. Hatakeyama S, et al. J Biol Chem, 2001 Aug 31. PMID 11435423
    4. Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones. Hatakeyama S, et al. Genes Cells, 2004 Jun. PMID 15189447
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-ubiquitin ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-ubiquitin ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RING finger protein 37
    Names
    RING-type E3 ubiquitin transferase RNF37
    U-box domain-containing protein 5
    UbcM4-interacting protein 5
    ubiquitin-conjugating enzyme 7-interacting protein 5
    NP_001242922.1
    NP_001242923.1
    NP_542129.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001255993.1 → NP_001242922.1  RING finger protein 37

      See identical proteins and their annotated locations for NP_001242922.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK034114, AK158052, AL731707, AW060426
      Consensus CDS
      CCDS16747.1
      UniProtKB/Swiss-Prot
      Q925F4
      UniProtKB/TrEMBL
      Q3TZ72, Q543N0
      Conserved Domains (2) summary
      pfam04564
      Location:259 → 337
      U-box; U-box domain
      pfam14634
      Location:484 → 527
      zf-RING_5; zinc-RING finger domain

    2. NM_001255994.1 → NP_001242923.1  RING finger protein 37

      See identical proteins and their annotated locations for NP_001242923.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AF360997, AL731707, AW060426
      Consensus CDS
      CCDS16747.1
      UniProtKB/Swiss-Prot
      Q925F4
      UniProtKB/TrEMBL
      Q3TZ72, Q543N0
      Related
      ENSMUSP00000028761.5, ENSMUST00000028761.5
      Conserved Domains (2) summary
      pfam04564
      Location:259 → 337
      U-box; U-box domain
      pfam14634
      Location:484 → 527
      zf-RING_5; zinc-RING finger domain

    3. NM_080562.5 → NP_542129.2  RING finger protein 37

      See identical proteins and their annotated locations for NP_542129.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK034114, AL731707, AW060426
      Consensus CDS
      CCDS16747.1
      UniProtKB/Swiss-Prot
      Q925F4
      UniProtKB/TrEMBL
      Q3TZ72, Q543N0
      Conserved Domains (2) summary
      pfam04564
      Location:259 → 337
      U-box; U-box domain
      pfam14634
      Location:484 → 527
      zf-RING_5; zinc-RING finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      130431916..130471958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q925F4.2 GenPept UniProtKB/Swiss-Prot:Q925F4

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