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    Herc1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 235439, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Herc1provided by MGI
    Official Full Name
    HECT and RLD domain containing E3 ubiquitin protein ligase family member 1provided by MGI
    Primary source
    MGI:MGI:2384589
    See related
    Ensembl:ENSMUSG00000038664 AllianceGenome:MGI:2384589
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    tbl; B230218H07; 2810449H11Rik; D130015N03Rik
    Summary
    Acts upstream of or within negative regulation of autophagy; nervous system development; and neuromuscular process controlling balance. Is expressed in several structures, including jaw bone; nervous system; sensory organ; thymus primordium; and vibrissa. Orthologous to human HERC1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 13.0), CNS E14 (RPKM 11.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Herc1 in Genome Data Viewer
    Location:
    9 C; 9 35.86 cM
    Exon count:
    78
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (66257694..66416057)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (66350412..66508775)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24478 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66128344-66128644 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:66129452-66129653 Neighboring gene STARR-positive B cell enhancer ABC_E2899 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene predicted gene, 39364 Neighboring gene STARR-positive B cell enhancer ABC_E6759 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66213808-66214109 Neighboring gene predicted gene, 30447 Neighboring gene predicted gene, 50499 Neighboring gene predicted gene, 23428 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66312941-66313241 Neighboring gene STARR-positive B cell enhancer ABC_E3841 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66351571-66351871 Neighboring gene F-box and leucine-rich repeat protein 22 Neighboring gene ubiquitin specific peptidase 3 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66440763-66441064 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66444915-66445215 Neighboring gene STARR-positive B cell enhancer ABC_E2900 Neighboring gene STARR-seq mESC enhancer starr_24480 Neighboring gene STARR-positive B cell enhancer ABC_E11413 Neighboring gene carbonic anhydrase 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling. Pedrazza L, et al. Cell Death Dis, 2023 Jan 12. PMID 36635269, Free PMC Article
    2. The HERC1 E3 Ubiquitin Ligase is essential for normal development and for neurotransmission at the mouse neuromuscular junction. Bachiller S, et al. Cell Mol Life Sci, 2015 Aug. PMID 25746226, Free PMC Article
    3. Preventive motor training but not progenitor grafting ameliorates cerebellar ataxia and deregulated autophagy in tambaleante mice. Fucà E, et al. Neurobiol Dis, 2017 Jun. PMID 28237314
    4. HERC1 Ubiquitin Ligase Is Required for Normal Axonal Myelination in the Peripheral Nervous System. Bachiller S, et al. Mol Neurobiol, 2018 Dec. PMID 29603094
    5. The HERC1 ubiquitin ligase regulates presynaptic membrane dynamics of central synapses. Montes-Fernández MA, et al. Sci Rep, 2020 Jul 21. PMID 32694577, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling.
      Title: HERC1 deficiency causes osteopenia through transcriptional program dysregulation during bone remodeling.
    2. The Herc1 gene in neurobiology.
      Title: The Herc1 gene in neurobiology.
    3. The aim of the present work was to study to which extent the alteration in HERC1 may affect other cells in the nervous system and how this may influence the motor dysfunction observed in mice.
      Title: HERC1 Ubiquitin Ligase Is Required for Normal Axonal Myelination in the Peripheral Nervous System.
    4. The HERC1 E3 Ubiquitin Ligase is fundamental for normal muscle function.
      Title: The HERC1 E3 Ubiquitin Ligase is essential for normal development and for neurotransmission at the mouse neuromuscular junction.
    5. The first mutation in the Herc1 gene contribute to the functional annotation of the encoded E3 ubiquitin ligase and underline the crucial and unexpected role of this protein in Purkinje cell physiology.
      Title: Progressive Purkinje cell degeneration in tambaleante mutant mice is a consequence of a missense mutation in HERC1 E3 ubiquitin ligase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Gene trapped (1) 
    • Spontaneous (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7618

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cerebellar Purkinje cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within corpus callosum development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase HERC1
    Names
    hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
    NP_663592.3
    XP_006511166.1
    XP_006511167.1
    XP_006511168.1
    XP_006511169.1
    XP_006511170.1
    XP_006511171.1
    XP_030100191.1
    XP_030100192.1
    XP_030100193.1
    XP_030100194.1
    XP_030100195.1
    XP_036010796.1
    XP_036010797.1
    XP_036010798.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145617.3 → NP_663592.3  probable E3 ubiquitin-protein ligase HERC1

      Status: VALIDATED

      Source sequence(s)
      AC161382, AC166755
      Consensus CDS
      CCDS52840.1
      UniProtKB/TrEMBL
      E9PZP8
      Related
      ENSMUSP00000044801.7, ENSMUST00000042824.13
      Conserved Domains (9) summary
      smart00119
      Location:4502 → 4835
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      COG2319
      Location:3392 → 3776
      WD40; WD40 repeat [General function prediction only]
      cd00078
      Location:4471 → 4839
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2751 → 2794
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      pfam00415
      Location:4098 → 4147
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:4291 → 4320
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat
      sd00039
      Location:3584 → 3622
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2030 → 2187
      SPRY_HERC1; SPRY domain in HERC1
      cl02567
      Location:3422 → 3773
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      66257694..66416057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511103.3 → XP_006511166.1  probable E3 ubiquitin-protein ligase HERC1 isoform X1

      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4497 → 4865
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2760 → 2803
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3610 → 3648
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2039 → 2196
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3448 → 3799
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_006511108.3 → XP_006511171.1  probable E3 ubiquitin-protein ligase HERC1 isoform X9

      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4480 → 4848
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2760 → 2803
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3593 → 3631
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2039 → 2196
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3431 → 3782
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_006511105.3 → XP_006511168.1  probable E3 ubiquitin-protein ligase HERC1 isoform X3

      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4490 → 4858
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2760 → 2803
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3603 → 3641
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2039 → 2196
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3441 → 3792
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_036154904.1 → XP_036010797.1  probable E3 ubiquitin-protein ligase HERC1 isoform X10

      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4473 → 4841
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2760 → 2803
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3586 → 3624
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2039 → 2196
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3424 → 3775
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_006511106.3 → XP_006511169.1  probable E3 ubiquitin-protein ligase HERC1 isoform X4

      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4489 → 4857
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2752 → 2795
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3602 → 3640
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2039 → 2196
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3440 → 3791
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_006511104.3 → XP_006511167.1  probable E3 ubiquitin-protein ligase HERC1 isoform X2

      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4496 → 4864
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2759 → 2802
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3609 → 3647
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2038 → 2195
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3447 → 3798
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. XM_030244331.1 → XP_030100191.1  probable E3 ubiquitin-protein ligase HERC1 isoform X6

      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4488 → 4856
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2751 → 2794
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3601 → 3639
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2038 → 2195
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3439 → 3790
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. XM_006511107.3 → XP_006511170.1  probable E3 ubiquitin-protein ligase HERC1 isoform X5

      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4488 → 4856
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2751 → 2794
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3601 → 3639
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2030 → 2187
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3439 → 3790
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    9. XM_036154903.1 → XP_036010796.1  probable E3 ubiquitin-protein ligase HERC1 isoform X8

      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4480 → 4848
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2743 → 2786
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3593 → 3631
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2030 → 2187
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3431 → 3782
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    10. XM_030244332.1 → XP_030100192.1  probable E3 ubiquitin-protein ligase HERC1 isoform X7

      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4487 → 4855
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2750 → 2793
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3600 → 3638
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2029 → 2186
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3438 → 3789
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    11. XM_036154905.1 → XP_036010798.1  probable E3 ubiquitin-protein ligase HERC1 isoform X12

      Conserved Domains (6) summary
      COG5184
      Location:2661 → 3009
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:3136 → 3504
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:1399 → 1442
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:2249 → 2287
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:678 → 835
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:2087 → 2438
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    12. XM_030244335.2 → XP_030100195.1  probable E3 ubiquitin-protein ligase HERC1 isoform X13

      Conserved Domains (6) summary
      COG5184
      Location:2660 → 3008
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:3135 → 3503
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:1398 → 1441
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:2248 → 2286
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:677 → 834
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:2086 → 2437
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    13. XM_030244334.2 → XP_030100194.1  probable E3 ubiquitin-protein ligase HERC1 isoform X12

      Conserved Domains (6) summary
      COG5184
      Location:2661 → 3009
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:3136 → 3504
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:1399 → 1442
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:2249 → 2287
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:678 → 835
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:2087 → 2438
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    14. XM_030244333.1 → XP_030100193.1  probable E3 ubiquitin-protein ligase HERC1 isoform X11

      Conserved Domains (6) summary
      COG5184
      Location:2670 → 3018
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:3145 → 3513
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:1408 → 1451
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:2258 → 2296
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:687 → 844
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:2096 → 2447
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_001778881.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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