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    Usp24 ubiquitin specific peptidase 24 [ Mus musculus (house mouse) ]

    Gene ID: 329908, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Usp24provided by MGI
    Official Full Name
    ubiquitin specific peptidase 24provided by MGI
    Primary source
    MGI:MGI:1919936
    See related
    Ensembl:ENSMUSG00000028514 AllianceGenome:MGI:1919936
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B130021E18; 2700066K03Rik; 2810030C21Rik
    Summary
    Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability. Predicted to be active in cytosol and nucleus. Is expressed in olfactory cortex. Orthologous to human USP24 (ubiquitin specific peptidase 24). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 8.3), thymus adult (RPKM 7.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Usp24 in Genome Data Viewer
    Location:
    4 C7; 4 49.44 cM
    Exon count:
    71
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (106173179..106303798)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (106315980..106446613)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54246 Neighboring gene STARR-seq mESC enhancer starr_10989 Neighboring gene predicted gene 12724 Neighboring gene STARR-seq mESC enhancer starr_10992 Neighboring gene predicted gene, 40218 Neighboring gene proprotein convertase subtilisin/kexin type 9 Neighboring gene predicted gene, 30487 Neighboring gene barttin CLCNK type accessory beta subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. USP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy. Young MJ, et al. Cell Death Differ, 2024 May. PMID 38491202, Free PMC Article
    2. Upregulation of NF-κB by USP24 aggravates ferroptosis in diabetic cardiomyopathy. Wu S, et al. Free Radic Biol Med, 2024 Jan. PMID 38056575
    3. USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma. Bedekovics T, et al. Cancer Res, 2021 Mar 1. PMID 33355202
    4. Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling. Jahan AS, et al. Proc Natl Acad Sci U S A, 2016 Feb 9. PMID 26811477, Free PMC Article
    5. Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells. Asadi F, et al. Front Endocrinol (Lausanne), 2018. PMID 30713523, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Upregulation of NF-kappaB by USP24 aggravates ferroptosis in diabetic cardiomyopathy.
      Title: Upregulation of NF-κB by USP24 aggravates ferroptosis in diabetic cardiomyopathy.
    2. USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma.
      Title: USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Gene trapped (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 24
    Names
    deubiquitinating enzyme 24
    ubiquitin specific protease 24
    ubiquitin thioesterase 24
    ubiquitin thiolesterase 24
    ubiquitin-specific-processing protease 24
    NP_899048.2
    XP_006503239.1
    XP_006503240.1
    XP_006503241.1
    XP_006503243.1
    XP_036020087.1
    XP_036020089.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183225.2 → NP_899048.2  ubiquitin carboxyl-terminal hydrolase 24

      See identical proteins and their annotated locations for NP_899048.2

      Status: VALIDATED

      Source sequence(s)
      AL840623, AL954352
      Consensus CDS
      CCDS51251.1
      UniProtKB/Swiss-Prot
      B1AY13, Q8BLI7
      Conserved Domains (3) summary
      cd02659
      Location:1684 → 2041
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14286
      Location:6 → 42
      UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
      pfam00443
      Location:1686 → 2036
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      106173179..106303798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503180.5 → XP_006503243.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X6

      Conserved Domains (2) summary
      cd14286
      Location:6 → 42
      UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
      cd17065
      Location:972 → 1050
      Ubl_UBP24; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins

    2. XM_036164196.1 → XP_036020089.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X5

      Conserved Domains (3) summary
      cd14286
      Location:6 → 42
      UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
      cd17065
      Location:972 → 1050
      Ubl_UBP24; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
      cl02553
      Location:1704 → 1865
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    3. XM_006503177.5 → XP_006503240.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X2

      Conserved Domains (3) summary
      cd02659
      Location:1704 → 2061
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14286
      Location:6 → 42
      UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
      cd17065
      Location:972 → 1050
      Ubl_UBP24; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins

    4. XM_006503176.5 → XP_006503239.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X1

      UniProtKB/TrEMBL
      A0AAG1F6P4
      Related
      ENSMUSP00000092538.6, ENSMUST00000094933.6
      Conserved Domains (3) summary
      cd02659
      Location:1704 → 2061
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14286
      Location:6 → 42
      UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
      cd17065
      Location:972 → 1050
      Ubl_UBP24; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins

    5. XM_036164194.1 → XP_036020087.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X3

      Conserved Domains (2) summary
      cd02659
      Location:1532 → 1889
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd17065
      Location:800 → 878
      Ubl_UBP24; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins

    6. XM_006503178.4 → XP_006503241.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X4

      Conserved Domains (2) summary
      cd02659
      Location:1092 → 1449
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd17065
      Location:360 → 438
      Ubl_UBP24; ubiquitin-like (Ubl) domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1AY13.1 GenPept UniProtKB/Swiss-Prot:B1AY13

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