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    Vrk1 vaccinia related kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 22367, updated on 9-Dec-2024

    Summary

    Official Symbol
    Vrk1provided by MGI
    Official Full Name
    vaccinia related kinase 1provided by MGI
    Primary source
    MGI:MGI:1261847
    See related
    Ensembl:ENSMUSG00000021115 AllianceGenome:MGI:1261847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    51PK; Gm40568; Gm46378
    Summary
    Enables protein serine/threonine kinase activity. Involved in regulation of neuron migration. Acts upstream of or within protein autophosphorylation. Located in nucleus. Is expressed in several structures, including dorsal mesogastrium; hemolymphoid system; liver; metanephros; and yolk sac. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 10 and pontocerebellar hypoplasia type 1A. Orthologous to human VRK1 (VRK serine/threonine kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 11.6), CNS E11.5 (RPKM 9.0) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Vrk1 in Genome Data Viewer
    Location:
    12 E- F1; 12 56.37 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (105976398..106044578)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (106010139..106078318)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33194 Neighboring gene poly (A) polymerase alpha Neighboring gene STARR-seq mESC enhancer starr_33197 Neighboring gene predicted gene, 19554 Neighboring gene predicted gene, 32370 Neighboring gene STARR-seq mESC enhancer starr_33198 Neighboring gene VISTA enhancer mm1604 Neighboring gene STARR-positive B cell enhancer ABC_E7178 Neighboring gene STARR-positive B cell enhancer ABC_E3067 Neighboring gene STARR-seq mESC enhancer starr_33203 Neighboring gene predicted gene, 32723 Neighboring gene predicted gene, 32635 Neighboring gene STARR-seq mESC enhancer starr_33204 Neighboring gene predicted gene, 32776

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Gene trapped (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AX kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2AX kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleosomal DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleosomal DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Cajal body organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Cajal body organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in Golgi disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Golgi disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Cajal body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Golgi stack ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi stack ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase VRK1
    Names
    serine/threonine-protein kinase 51PK
    NP_001025014.1
    NP_001025015.1
    NP_001351294.1
    NP_001351296.1
    NP_001351297.1
    NP_001409909.1
    NP_035835.1
    XP_006515872.1
    XP_006515873.1
    XP_006515874.1
    XP_011242406.1
    XP_017170534.1
    XP_030102545.1
    XP_030102546.1
    XP_030102547.1
    XP_030102548.1
    XP_030102549.1
    XP_030102550.1
    XP_030102551.1
    XP_030102553.1
    XP_030102554.1
    XP_030102556.1
    XP_036013274.1
    XP_036013275.1
    XP_036013276.1
    XP_036013277.1
    XP_036013278.1
    XP_036013279.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029843.2NP_001025014.1  serine/threonine-protein kinase VRK1 isoform b

      See identical proteins and their annotated locations for NP_001025014.1

      Status: VALIDATED

      Source sequence(s)
      AK032344, AV567830, BY130767
      Consensus CDS
      CCDS26157.1
      UniProtKB/TrEMBL
      Q3TL56, Q3UWH3
      Related
      ENSMUSP00000082101.5, ENSMUST00000085026.12
      Conserved Domains (1) summary
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    2. NM_001029844.2NP_001025015.1  serine/threonine-protein kinase VRK1 isoform c

      See identical proteins and their annotated locations for NP_001025015.1

      Status: VALIDATED

      Source sequence(s)
      AK032344, AV567830, BY130767
      Consensus CDS
      CCDS26158.1
      UniProtKB/TrEMBL
      Q3TL56
      Related
      ENSMUSP00000071922.6, ENSMUST00000072040.7
      Conserved Domains (1) summary
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    3. NM_001364365.1NP_001351294.1  serine/threonine-protein kinase VRK1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC144543, AC163040
      Consensus CDS
      CCDS26158.1
      UniProtKB/TrEMBL
      Q3TL56
      Conserved Domains (1) summary
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    4. NM_001364367.1NP_001351296.1  serine/threonine-protein kinase VRK1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC144543, AC163040
      Consensus CDS
      CCDS36551.1
      UniProtKB/Swiss-Prot
      O88635, O88636, Q80X41, Q8C2P7, Q91YH9
      UniProtKB/TrEMBL
      Q3TL56
      Related
      ENSMUSP00000152109.2, ENSMUST00000220629.2
      Conserved Domains (1) summary
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    5. NM_001364368.1NP_001351297.1  serine/threonine-protein kinase VRK1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC144543, AC163040
      UniProtKB/TrEMBL
      Q3TL56
      Conserved Domains (1) summary
      cd14122
      Location:26324
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    6. NM_001422980.1NP_001409909.1  serine/threonine-protein kinase VRK1 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC144543, AC163040
      UniProtKB/TrEMBL
      Q3TL56
    7. NM_011705.4NP_035835.1  serine/threonine-protein kinase VRK1 isoform a

      See identical proteins and their annotated locations for NP_035835.1

      Status: VALIDATED

      Source sequence(s)
      AK032344, AV567830, BB749810, BY130767
      Consensus CDS
      CCDS36551.1
      UniProtKB/Swiss-Prot
      O88635, O88636, Q80X41, Q8C2P7, Q91YH9
      UniProtKB/TrEMBL
      Q3TL56
      Related
      ENSMUSP00000021539.9, ENSMUST00000021539.16
      Conserved Domains (1) summary
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      105976398..106044578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246689.1XP_030102549.1  serine/threonine-protein kinase VRK1 isoform X6

      UniProtKB/TrEMBL
      Q3TL56
      Conserved Domains (1) summary
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    2. XM_006515810.5XP_006515873.1  serine/threonine-protein kinase VRK1 isoform X2

      See identical proteins and their annotated locations for XP_006515873.1

      UniProtKB/Swiss-Prot
      O88635, O88636, Q80X41, Q8C2P7, Q91YH9
      UniProtKB/TrEMBL
      Q3TL56
      Conserved Domains (1) summary
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    3. XM_030246687.2XP_030102547.1  serine/threonine-protein kinase VRK1 isoform X4

      UniProtKB/TrEMBL
      Q3TL56, Q3UWH3
      Conserved Domains (1) summary
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    4. XM_036157384.1XP_036013277.1  serine/threonine-protein kinase VRK1 isoform X8

      Conserved Domains (1) summary
      cl21453
      Location:26206
      PKc_like; Protein Kinases, catalytic domain
    5. XM_030246693.2XP_030102553.1  serine/threonine-protein kinase VRK1 isoform X8

      Conserved Domains (1) summary
      cl21453
      Location:26206
      PKc_like; Protein Kinases, catalytic domain
    6. XM_006515811.5XP_006515874.1  serine/threonine-protein kinase VRK1 isoform X2

      See identical proteins and their annotated locations for XP_006515874.1

      UniProtKB/Swiss-Prot
      O88635, O88636, Q80X41, Q8C2P7, Q91YH9
      UniProtKB/TrEMBL
      Q3TL56
      Conserved Domains (1) summary
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    7. XM_030246688.2XP_030102548.1  serine/threonine-protein kinase VRK1 isoform X5

      UniProtKB/TrEMBL
      Q3TL56
      Conserved Domains (1) summary
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    8. XM_036157382.1XP_036013275.1  serine/threonine-protein kinase VRK1 isoform X4

      UniProtKB/TrEMBL
      Q3TL56, Q3UWH3
      Conserved Domains (1) summary
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    9. XM_030246685.2XP_030102545.1  serine/threonine-protein kinase VRK1 isoform X3

      UniProtKB/TrEMBL
      A0A1Y7VMH3
      Conserved Domains (1) summary
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    10. XM_030246694.2XP_030102554.1  serine/threonine-protein kinase VRK1 isoform X10

      Conserved Domains (1) summary
      cl21453
      Location:26206
      PKc_like; Protein Kinases, catalytic domain
    11. XM_036157385.1XP_036013278.1  serine/threonine-protein kinase VRK1 isoform X11

      Conserved Domains (1) summary
      cl21453
      Location:26206
      PKc_like; Protein Kinases, catalytic domain
    12. XM_030246690.2XP_030102550.1  serine/threonine-protein kinase VRK1 isoform X6

      UniProtKB/TrEMBL
      Q3TL56
      Conserved Domains (1) summary
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    13. XM_030246696.2XP_030102556.1  serine/threonine-protein kinase VRK1 isoform X11

      Conserved Domains (1) summary
      cl21453
      Location:26206
      PKc_like; Protein Kinases, catalytic domain
    14. XM_036157383.1XP_036013276.1  serine/threonine-protein kinase VRK1 isoform X4

      UniProtKB/TrEMBL
      Q3TL56, Q3UWH3
      Conserved Domains (1) summary
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    15. XM_006515809.3XP_006515872.1  serine/threonine-protein kinase VRK1 isoform X2

      See identical proteins and their annotated locations for XP_006515872.1

      UniProtKB/Swiss-Prot
      O88635, O88636, Q80X41, Q8C2P7, Q91YH9
      UniProtKB/TrEMBL
      Q3TL56
      Conserved Domains (1) summary
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    16. XM_030246686.1XP_030102546.1  serine/threonine-protein kinase VRK1 isoform X4

      UniProtKB/TrEMBL
      Q3TL56, Q3UWH3
      Conserved Domains (1) summary
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    17. XM_030246691.1XP_030102551.1  serine/threonine-protein kinase VRK1 isoform X6

      UniProtKB/TrEMBL
      Q3TL56
      Conserved Domains (1) summary
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    18. XM_036157381.1XP_036013274.1  serine/threonine-protein kinase VRK1 isoform X2

      UniProtKB/Swiss-Prot
      O88635, O88636, Q80X41, Q8C2P7, Q91YH9
      UniProtKB/TrEMBL
      Q3TL56
      Conserved Domains (1) summary
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    19. XM_017315045.3XP_017170534.1  serine/threonine-protein kinase VRK1 isoform X1

      UniProtKB/TrEMBL
      Q3TL56
      Conserved Domains (1) summary
      cd14122
      Location:26326
      STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
    20. XM_011244104.2XP_011242406.1  serine/threonine-protein kinase VRK1 isoform X9

      Conserved Domains (1) summary
      cl21453
      Location:1198
      PKc_like; Protein Kinases, catalytic domain
    21. XM_036157386.1XP_036013279.1  serine/threonine-protein kinase VRK1 isoform X12

      UniProtKB/TrEMBL
      Q8CA60
      Conserved Domains (1) summary
      cl21453
      Location:1198
      PKc_like; Protein Kinases, catalytic domain