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    Fgd5 FYVE, RhoGEF and PH domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 232237, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fgd5provided by MGI
    Official Full Name
    FYVE, RhoGEF and PH domain containing 5provided by MGI
    Primary source
    MGI:MGI:2443369
    See related
    Ensembl:ENSMUSG00000034037 AllianceGenome:MGI:2443369
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZFYVE23; mFLJ00274; C330025N11Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Orthologous to human FGD5 (FYVE, RhoGEF and PH domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 11.1), subcutaneous fat pad adult (RPKM 5.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fgd5 in Genome Data Viewer
    Location:
    6 D1; 6 41.0 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (91955809..92052986)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (91978827..92076005)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930590J08 gene Neighboring gene predicted gene, 53299 Neighboring gene STARR-positive B cell enhancer ABC_E539 Neighboring gene nuclear receptor subfamily 2, group C, member 2 Neighboring gene predicted gene, 46967 Neighboring gene mitochondrial ribosomal protein S25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation. Zhang T, et al. Dev Cell, 2024 Aug 19. PMID 38821057
    2. LncRNA FGD5-AS1 Promotes Abdominal Aortic Aneurysm Growth Through the Activation of MMP3 in Vascular Smooth Muscle Cells. Xu Z, et al. Int Heart J, 2023 May 31. PMID 37197924
    3. HSC-independent definitive hematopoiesis persists into adult life. Kobayashi M, et al. Cell Rep, 2023 Mar 28. PMID 36906851, Free PMC Article
    4. Endothelial cell-specific FGD5 involvement in vascular pruning defines neovessel fate in mice. Cheng C, et al. Circulation, 2012 Jun 26. PMID 22661514
    5. Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. Konturek-Ciesla A, et al. Cell Rep, 2023 Apr 25. PMID 36961818

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation.
      Title: FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation.
    2. LncRNA FGD5-AS1 Promotes Abdominal Aortic Aneurysm Growth Through the Activation of MMP3 in Vascular Smooth Muscle Cells.
      Title: LncRNA FGD5-AS1 Promotes Abdominal Aortic Aneurysm Growth Through the Activation of MMP3 in Vascular Smooth Muscle Cells.
    3. Fgd5 identifies hematopoietic stem cells in the murine bone marrow.
      Title: Fgd5 identifies hematopoietic stem cells in the murine bone marrow.
    4. A new endothelial specific gene named FYVE, RhoGEF, and PH domain-containing 5 (FGD5) plays a crucial role in vascular pruning in a murine model.
      Title: Endothelial cell-specific FGD5 involvement in vascular pruning defines neovessel fate in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ00274

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FYVE, RhoGEF and PH domain-containing protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172731.3 → NP_766319.3  FYVE, RhoGEF and PH domain-containing protein 5

      Status: VALIDATED

      Source sequence(s)
      AK086031, AW046885, BB612302, BC060664, CB246280, CN446877, CX568970
      Consensus CDS
      CCDS20371.2
      UniProtKB/TrEMBL
      E9QKY4, Q571N6
      Related
      ENSMUSP00000086748.3, ENSMUST00000089334.9
      Conserved Domains (5) summary
      cd13237
      Location:1418 → 1508
      PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
      pfam00169
      Location:1167 → 1258
      PH; PH domain
      pfam00621
      Location:946 → 1134
      RhoGEF; RhoGEF domain
      cl17171
      Location:1152 → 1274
      PH-like; Pleckstrin homology-like domain
      cl22851
      Location:1288 → 1354
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      91955809..92052986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166057.1 → XP_036021950.1  FYVE, RhoGEF and PH domain-containing protein 5 isoform X2

      UniProtKB/TrEMBL
      Q571N6
      Conserved Domains (4) summary
      COG5271
      Location:95 → 407
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cl28890
      Location:1289 → 1355
      FYVE_like_SF; FYVE domain like superfamily
      pfam00621
      Location:946 → 1134
      RhoGEF; RhoGEF domain
      cl17171
      Location:1153 → 1275
      PH-like; Pleckstrin homology-like domain

    2. XM_006506000.5 → XP_006506063.1  FYVE, RhoGEF and PH domain-containing protein 5 isoform X1

      UniProtKB/TrEMBL
      Q571N6
      Conserved Domains (5) summary
      cd13237
      Location:1419 → 1509
      PH2_FGD5_FGD6; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 5 and 6 pleckstrin homology (PH) domain, C-terminus
      TIGR00927
      Location:95 → 339
      2A1904; K+-dependent Na+/Ca+ exchanger
      cl28890
      Location:1289 → 1355
      FYVE_like_SF; FYVE domain like superfamily
      pfam00621
      Location:946 → 1134
      RhoGEF; RhoGEF domain
      cl17171
      Location:1153 → 1275
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80UZ0.2 GenPept UniProtKB/Swiss-Prot:Q80UZ0

    Gene LinkOut

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