Pard6g par-6 family cell polarity regulator gamma [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pard6gprovided by MGI
Official Full Name: par-6 family cell polarity regulator gammaprovided by MGI
Primary source: MGI:MGI:2135606
See related: Ensembl:ENSMUSG00000056214 AllianceGenome:MGI:2135606
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Par6a; 2410049N21Rik
Summary: Predicted to be involved in centrosome cycle; establishment or maintenance of cell polarity; and regulation of cellular localization. Predicted to be located in bicellular tight junction; cytoplasm; and plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in apical plasma membrane; cell cortex; and nucleus. Is expressed in several structures, including alimentary system; pharyngo-tympanic tube; skeleton; skin; and submandibular gland primordium. Orthologous to human PARD6G (par-6 family cell polarity regulator gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in limb E14.5 (RPKM 8.4), CNS E11.5 (RPKM 8.1) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E3; 18 53.22 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (80090045..80162855)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (80046830..80119640)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prkci and its downstream partners, such a Pard6g, direct polarized cell division of luminal myocardial cells to drive trabeculation in the nascent heart.
Title: Atypical Protein Kinase C-Dependent Polarized Cell Division Is Required for Myocardial Trabeculation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237855

Pard6g (e-PCR), detects polymorphism
- UniSTS:499188

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in centrosome cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cellular localization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: partitioning defective 6 homolog gamma

Names: PAR-6 gamma; par-6 partitioning defective 6 homolog gamma; partitioning-defective protein 6, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053117.3 → NP_444347.3 partitioning defective 6 homolog gamma

See identical proteins and their annotated locations for NP_444347.3

Status: VALIDATED

Source sequence(s)

AC131065, AK035811, BB663070, BY732180

Consensus CDS

CCDS29363.1

UniProtKB/Swiss-Prot

Q9JK84

UniProtKB/TrEMBL

Q8CFJ8

Related

ENSMUSP00000069182.8, ENSMUST00000070219.9

Conserved Domains (2) summary

cd06403
Location:19 → 98

PB1_Par6; The PB1 domain is an essential part of Par6 protein which in complex with Par3 and aPKC proteins is crucial for establishment of apical-basal polarity of animal cells. The PB1 domain is a modular domain mediating specific protein-protein interactions ...

cd00992
Location:157 → 248

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

80090045..80162855

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161338.1 → XP_036017231.1 partitioning defective 6 homolog gamma isoform X1

Conserved Domains (1) summary

cd00992
Location:22 → 113

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...