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    RALGDS ral guanine nucleotide dissociation stimulator [ Homo sapiens (human) ]

    Gene ID: 5900, updated on 10-Dec-2024

    Summary

    Official Symbol
    RALGDSprovided by HGNC
    Official Full Name
    ral guanine nucleotide dissociation stimulatorprovided by HGNC
    Primary source
    HGNC:HGNC:9842
    See related
    Ensembl:ENSG00000160271 MIM:601619; AllianceGenome:HGNC:9842
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RGF; RGDS; RalGEF
    Summary
    Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010]
    Expression
    Ubiquitous expression in skin (RPKM 22.8), gall bladder (RPKM 22.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RALGDS in Genome Data Viewer
    Location:
    9q34.13-q34.2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (133097722..133149210, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (145311872..145363296, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (135973109..136024597, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:135965875-135966376 Neighboring gene small nucleolar RNA U13 Neighboring gene carboxyl ester lipase pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:135976589-135977788 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29228 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:135995531-135996227 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20442 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20443 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20444 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20445 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:136002206-136003405 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136008097-136008641 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29233 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136019197-136019756 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20446 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20447 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136024237-136024884 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136038755-136039477 Neighboring gene globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136062831-136063698 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136075403-136076124 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:136081856-136082043 Neighboring gene odorant binding protein 2B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Potential readthrough

    Included gene: GBGT1

    Clone Names

    • FLJ20922

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase regulator activity PubMed 
    enables GTPase regulator activity PubMed 
    enables guanyl-nucleotide exchange factor activity  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in brush border PubMed 
    located_in cytosol PubMed 
    located_in cytosol  
    located_in nucleus PubMed 
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    ral guanine nucleotide dissociation stimulator
    Names
    ral guanine nucleotide exchange factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042368.3 → NP_001035827.1  ral guanine nucleotide dissociation stimulator isoform 2

      See identical proteins and their annotated locations for NP_001035827.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and represents use of an alternate promoter, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AF027169, BC033198, BC059362, HY002335
      Consensus CDS
      CCDS43897.1
      UniProtKB/TrEMBL
      A0A2R8Y471
      Related
      ENSP00000376867.3, ENST00000393160.7
      Conserved Domains (3) summary
      cd00153
      Location:743 → 828
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00229
      Location:57 → 193
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:327 → 589
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    2. NM_001271774.2 → NP_001258703.1  ral guanine nucleotide dissociation stimulator isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and represents use of an alternate promoter, compared to variant 1. This variant also uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AF295773, AK301470, AL162417, BC033198, BC059362, DC339956
      Consensus CDS
      CCDS65174.1
      UniProtKB/TrEMBL
      A0A2R8Y471
      Related
      ENSP00000361132.3, ENST00000372062.8
      Conserved Domains (3) summary
      cd00153
      Location:769 → 854
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00229
      Location:95 → 219
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:353 → 615
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    3. NM_001271775.2 → NP_001258704.1  ral guanine nucleotide dissociation stimulator isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region and represents use of an alternate promoter, compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK127524, AL162417, BC033198, BC059362
      Consensus CDS
      CCDS65173.1
      UniProtKB/TrEMBL
      A0A2R8Y471
      Related
      ENSP00000376864.3, ENST00000393157.8
      Conserved Domains (3) summary
      cd00153
      Location:797 → 882
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00229
      Location:111 → 247
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:381 → 643
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    4. NM_001271776.2 → NP_001258705.1  ral guanine nucleotide dissociation stimulator isoform 5

      See identical proteins and their annotated locations for NP_001258705.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AF295773, BC033198, BC059362, DR003030
      Consensus CDS
      CCDS65172.1
      UniProtKB/TrEMBL
      Q8TEK9
      Related
      ENSP00000361117.3, ENST00000372047.7
      Conserved Domains (3) summary
      cd00153
      Location:786 → 871
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00229
      Location:112 → 236
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:370 → 632
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    5. NM_006266.4 → NP_006257.1  ral guanine nucleotide dissociation stimulator isoform 1

      See identical proteins and their annotated locations for NP_006257.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF295773, BC033198, BC059362, DB480866, DR003030
      Consensus CDS
      CCDS6959.1
      UniProtKB/Swiss-Prot
      B7Z753, E7ER93, E7ERZ0, Q12967, Q5T7V4, Q6KH11, Q6PCE1, Q6ZSD5, Q9HAX7, Q9HAY1, Q9HCT1, Q9P2N8
      UniProtKB/TrEMBL
      Q8TEK9
      Related
      ENSP00000361120.3, ENST00000372050.8
      Conserved Domains (3) summary
      cd00153
      Location:798 → 883
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00229
      Location:112 → 248
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:382 → 644
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      133097722..133149210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      145311872..145363296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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