Anxa2 annexin A2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Anxa2provided by MGI
Official Full Name: annexin A2provided by MGI
Primary source: MGI:MGI:88246
See related: Ensembl:ENSMUSG00000032231 AllianceGenome:MGI:88246
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p36; Cal1h; PAP-IV
Summary: Predicted to enable several functions, including enzyme binding activity; enzyme inhibitor activity; and phospholipid binding activity. Involved in several processes, including mRNA transcription by RNA polymerase II; negative regulation of low-density lipoprotein particle receptor catabolic process; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including collagen fibril organization; fibrinolysis; and response to activity. Located in several cellular components, including Schmidt-Lanterman incisure; basolateral plasma membrane; and myelin sheath adaxonal region. Part of RNA polymerase II transcription regulator complex and plasma membrane protein complex. Is active in cornified envelope. Is expressed in several structures, including central nervous system; dorsal aorta; oral epithelium; primary palate; and yolk sac blood vessel. Human ortholog(s) of this gene implicated in osteonecrosis. Orthologous to several human genes including ANXA2 (annexin A2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in large intestine adult (RPKM 323.7), genital fat pad adult (RPKM 314.4) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 C; 9 38.58 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (69360978..69399074)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (69453683..69491792)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Annexin A2 promotes proliferative vitreoretinopathy in response to a macrophage inflammatory signal in mice.
Title: Annexin A2 promotes proliferative vitreoretinopathy in response to a macrophage inflammatory signal in mice.
Nuclear autoantigenic sperm protein facilitates glioblastoma progression and radioresistance by regulating the ANXA2/STAT3 axis.
Title: Nuclear autoantigenic sperm protein facilitates glioblastoma progression and radioresistance by regulating the ANXA2/STAT3 axis.
Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10.
Title: Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10.
Hspb1 protects against severe acute pancreatitis by attenuating apoptosis and ferroptosis via interacting with Anxa2 to restore the antioxidative activity of Prdx1.
Title: Hspb1 protects against severe acute pancreatitis by attenuating apoptosis and ferroptosis via interacting with Anxa2 to restore the antioxidative activity of Prdx1.
ANXA2 (annexin A2) is crucial to ATG7-mediated autophagy, leading to tumor aggressiveness in triple-negative breast cancer cells.
Title: ANXA2 (annexin A2) is crucial to ATG7-mediated autophagy, leading to tumor aggressiveness in triple-negative breast cancer cells.
Multi-Omics Profiling Identifies Microglial Annexin A2 as a Key Mediator of NF-kappaB Pro-inflammatory Signaling in Ischemic Reperfusion Injury.
Title: Multi-Omics Profiling Identifies Microglial Annexin A2 as a Key Mediator of NF-κB Pro-inflammatory Signaling in Ischemic Reperfusion Injury.
Inhibition of the membrane repair protein annexin-A2 prevents tumor invasion and metastasis.
Title: Inhibition of the membrane repair protein annexin-A2 prevents tumor invasion and metastasis.
RNASEH1-AS1 induced by H3K27ac stabilizes ANXA2 mRNA to promote the progression of colorectal cancer through recruiting BUD13.
Title: RNASEH1-AS1 induced by H3K27ac stabilizes ANXA2 mRNA to promote the progression of colorectal cancer through recruiting BUD13.
Accumulation of annexin A2 and S100A10 prevents apoptosis of apically delaminated, transformed epithelial cells.
Title: Accumulation of annexin A2 and S100A10 prevents apoptosis of apically delaminated, transformed epithelial cells.
Selenomethionine promotes ANXA2 phosphorylation for proliferation and protein synthesis of myoblasts and skeletal muscle growth.
Title: Selenomethionine promotes ANXA2 phosphorylation for proliferation and protein synthesis of myoblasts and skeletal muscle growth.

Submit: New GeneRIF Correction See all GeneRIFs (85)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129518 (e-PCR)
- UniSTS:212821

PMC152906P1 (e-PCR)
- UniSTS:271244

AW215814 (e-PCR)
- UniSTS:185794

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables S100 protein binding	IEA Inferred from Electronic Annotation more info
enables S100 protein binding	ISO Inferred from Sequence Orthology more info
enables bone sialoprotein binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A2 inhibitor activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A2 inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in body fluid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to acid chemical	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within collagen fibril organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fibrinolysis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane raft assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of low-density lipoprotein particle receptor catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in osteoclast development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of exocytosis	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of low-density lipoprotein particle clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of low-density lipoprotein particle receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of low-density lipoprotein receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of plasma membrane repair	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of plasminogen activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor-mediated endocytosis involved in cholesterol transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor-mediated endocytosis involved in cholesterol transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vacuole organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vesicle fusion	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle budding from membrane	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of AnxA2-p11 complex	IEA Inferred from Electronic Annotation more info
part_of AnxA2-p11 complex	ISO Inferred from Sequence Orthology more info
part_of PCSK9-AnxA2 complex	ISO Inferred from Sequence Orthology more info
part_of PCSK9-AnxA2 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in Schmidt-Lanterman incisure	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in cornified envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in extracellular space	HDA more info	PubMed
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in macropinosome	ISO Inferred from Sequence Orthology more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info
colocalizes_with membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in myelin sheath adaxonal region	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	NAS Non-traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
part_of plasma membrane protein complex	EXP Inferred from Experiment more info	PubMed
part_of plasma membrane protein complex	IPI Inferred from Physical Interaction more info	PubMed
part_of plasma membrane protein complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in stress fiber	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in vesicle	ISO Inferred from Sequence Orthology more info
is_active_in vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: annexin A2

Names: 33-kDa calcimedin; 33-kDa lymphocyte Ca<2+>- binding protein; 33kDa lymphocyte Ca<2+>- binding protein; 36-kDa calelectrin; annexin II; annexin-2; calpactin I heavy chain; calpactin-1 heavy chain; chromobindin-8; lipocortin II; placental anticoagulant protein IV; protein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.