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    Micall1 microtubule associated monooxygenase, calponin and LIM domain containing -like 1 [ Mus musculus (house mouse) ]

    Gene ID: 27008, updated on 24-Dec-2024

    Summary

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    Official Symbol
    Micall1provided by MGI
    Official Full Name
    microtubule associated monooxygenase, calponin and LIM domain containing -like 1provided by MGI
    Primary source
    MGI:MGI:105870
    See related
    Ensembl:ENSMUSG00000033039 AllianceGenome:MGI:105870
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D15N2e; MIRab13; D15Mit260; EST573322; EST820961; mKIAA1668
    Summary
    Enables small GTPase binding activity. Involved in neuron projection development. Predicted to be located in cytoplasmic side of endosome membrane; late endosome; and recycling endosome membrane. Is expressed in bladder; midgut; and pharyngo-tympanic tube. Orthologous to human MICALL1 (MICAL like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 29.6), testis adult (RPKM 25.5) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Micall1 in Genome Data Viewer
    Location:
    15 E1; 15 37.7 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78992750..79021100)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79108550..79136900)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 54 Neighboring gene STARR-positive B cell enhancer ABC_E1482 Neighboring gene STARR-seq mESC enhancer starr_39166 Neighboring gene eukaryotic translation initiation factor 3, subunit L Neighboring gene RIKEN cDNA 1700088E04 gene Neighboring gene STARR-positive B cell enhancer ABC_E7388 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide F Neighboring gene D6 enhancer downstream of Sox10 Neighboring gene MCS1C/MCS2 enhancer region 5' of Sox10 Neighboring gene SRY (sex determining region Y)-box 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis. Malinova TS, et al. Nat Commun, 2021 May 10. PMID 33972531, Free PMC Article
    2. Rab35 establishes the EHD1-association site by coordinating two distinct effectors during neurite outgrowth. Kobayashi H, et al. J Cell Sci, 2013 Jun 1. PMID 23572513
    3. The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions. Yamamura R, et al. Mol Biol Cell, 2008 Mar. PMID 18094055, Free PMC Article
    4. EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells. Nakajo A, et al. J Cell Biol, 2016 Feb 1. PMID 26833786, Free PMC Article
    5. The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling. Li L, et al. Cell Rep, 2019 Jul 16. PMID 31315048

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to nerve growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytic recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plasma membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plasma membrane tubulation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in slow endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in slow endocytic recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic side of endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    MICAL-like protein 1
    Names
    microtubule associated monoxygenase, calponin and LIM domain containing -like 1
    molecule interacting with Rab13

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177461.2 → NP_803412.1  MICAL-like protein 1

      See identical proteins and their annotated locations for NP_803412.1

      Status: VALIDATED

      Source sequence(s)
      AL589670
      Consensus CDS
      CCDS49667.1
      UniProtKB/Swiss-Prot
      E9QKJ4, Q8BGT6, Q8BJ60
      Related
      ENSMUSP00000042053.9, ENSMUST00000040320.10
      Conserved Domains (4) summary
      cd09444
      Location:165 → 219
      LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
      PHA03247
      Location:268 → 669
      PHA03247; large tegument protein UL36; Provisional
      cd21252
      Location:4 → 110
      CH_MICALL1; calponin homology (CH) domain found in MICAL-like protein 1
      pfam12130
      Location:691 → 815
      DUF3585; Protein of unknown function (DUF3585)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      78992750..79021100
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159443.1 → XP_036015336.1  MICAL-like protein 1 isoform X2

      Conserved Domains (4) summary
      cd09444
      Location:137 → 191
      LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
      PHA03247
      Location:259 → 658
      PHA03247; large tegument protein UL36; Provisional
      pfam12130
      Location:680 → 802
      DUF3585; Protein of unknown function (DUF3585)
      cl00030
      Location:22 → 82
      CH_SF; calponin homology (CH) domain superfamily

    2. XM_036159442.1 → XP_036015335.1  MICAL-like protein 1 isoform X1

      Conserved Domains (4) summary
      cd09444
      Location:165 → 219
      LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
      PHA03247
      Location:287 → 686
      PHA03247; large tegument protein UL36; Provisional
      pfam12130
      Location:708 → 830
      DUF3585; Protein of unknown function (DUF3585)
      cd21252
      Location:4 → 110
      CH_MICALL1; calponin homology (CH) domain found in MICAL-like protein 1

    3. XM_036159444.1 → XP_036015337.1  MICAL-like protein 1 isoform X3

      Conserved Domains (3) summary
      cd09444
      Location:36 → 90
      LIM_Mical_like_1; This domain belongs to the LIM domain family which are found on Mical (molecule interacting with CasL) like proteins
      PHA03247
      Location:158 → 557
      PHA03247; large tegument protein UL36; Provisional
      pfam12130
      Location:579 → 701
      DUF3585; Protein of unknown function (DUF3585)

    4. XM_006521024.2 → XP_006521087.1  MICAL-like protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006521087.1

      UniProtKB/Swiss-Prot
      Q8BGT6
      Conserved Domains (2) summary
      PHA03247
      Location:108 → 312
      PHA03247; large tegument protein UL36; Provisional
      pfam12130
      Location:334 → 458
      DUF3585; Protein of unknown function (DUF3585)

    RNA

    1. XR_004938842.1 RNA Sequence

      Related
      ENSMUST00000229031.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGT6.3 GenPept UniProtKB/Swiss-Prot:Q8BGT6

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