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    Cnot4 CCR4-NOT transcription complex, subunit 4 [ Mus musculus (house mouse) ]

    Gene ID: 53621, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cnot4provided by MGI
    Official Full Name
    CCR4-NOT transcription complex, subunit 4provided by MGI
    Primary source
    MGI:MGI:1859026
    See related
    Ensembl:ENSMUSG00000038784 AllianceGenome:MGI:1859026
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Not4; Not4h; Not4hp
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein autoubiquitination; regulation of megakaryocyte differentiation; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of CCR4-NOT complex. Is expressed in several structures, including central nervous system; genitourinary system; neural retina; and olfactory epithelium. Orthologous to human CNOT4 (CCR4-NOT transcription complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 3.6), cerebellum adult (RPKM 1.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cnot4 in Genome Data Viewer
    Location:
    6 B1; 6 15.2 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (34999000..35110646, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (35022065..35133754, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:34902551-34902660 Neighboring gene stimulated by retinoic acid gene 8 Neighboring gene solute carrier family 23 member 4 Neighboring gene STARR-seq mESC enhancer starr_15552 Neighboring gene STARR-positive B cell enhancer ABC_E2779 Neighboring gene predicted gene, 33046 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:35141265-35141448 Neighboring gene nucleoporin 205 Neighboring gene STARR-seq mESC enhancer starr_15553 Neighboring gene STARR-seq mESC enhancer starr_15554 Neighboring gene predicted gene, 23435 Neighboring gene short transmembrane mitochondrial protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The CNOT4 Subunit of the CCR4-NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis. Dai XX, et al. Adv Sci (Weinh), 2021 May. PMID 34026442, Free PMC Article
    2. Expression of genes involved in mammalian meiosis during the transition from egg to embryo. Hwang SY, et al. Mol Reprod Dev, 2001 Jun. PMID 11389549
    3. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Perez-Garcia V, et al. Nature, 2018 Mar 22. PMID 29539633, Free PMC Article
    4. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    5. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The CNOT4 Subunit of the CCR4-NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis.
      Title: The CNOT4 Subunit of the CCR4-NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of megakaryocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of CCR4-NOT complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT transcription complex subunit 4
    Names
    CCR4-associated factor 4
    E3 ubiquitin-protein ligase CNOT4
    RING-type E3 ubiquitin transferase CNOT4
    negative regulator of transcription 4
    potential transcriptional repressor NOT4Hp
    transcriptional repressor NOT4Hp
    NP_001157883.1
    NP_001157884.1
    NP_001157885.1
    NP_001157886.1
    NP_001397611.1
    NP_001397612.1
    NP_001397613.1
    NP_001397614.1
    NP_001397615.1
    NP_058573.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164411.2 → NP_001157883.1  CCR4-NOT transcription complex subunit 4 isoform 3

      See identical proteins and their annotated locations for NP_001157883.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC140110
      Consensus CDS
      CCDS80520.1
      UniProtKB/TrEMBL
      Q3TMD4
      Related
      ENSMUSP00000144409.2, ENSMUST00000202417.2
      Conserved Domains (1) summary
      COG5175
      Location:14 → 319
      MOT2; Transcriptional repressor [Transcription]

    2. NM_001164412.2 → NP_001157884.1  CCR4-NOT transcription complex subunit 4 isoform 4

      See identical proteins and their annotated locations for NP_001157884.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC140110
      Consensus CDS
      CCDS80519.1
      UniProtKB/TrEMBL
      Q05BG1
      Related
      ENSMUSP00000144352.2, ENSMUST00000202143.4
      Conserved Domains (3) summary
      COG5175
      Location:14 → 319
      MOT2; Transcriptional repressor [Transcription]
      cd12438
      Location:104 → 201
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:14 → 60
      zf-RING_4; RING/Ubox like zinc-binding domain

    3. NM_001164413.2 → NP_001157885.1  CCR4-NOT transcription complex subunit 4 isoform 1

      See identical proteins and their annotated locations for NP_001157885.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC140110
      Consensus CDS
      CCDS51747.1
      UniProtKB/TrEMBL
      A0A0R4J1K1
      Related
      ENSMUSP00000110645.3, ENSMUST00000114993.9
      Conserved Domains (3) summary
      COG5175
      Location:14 → 319
      MOT2; Transcriptional repressor [Transcription]
      cd12438
      Location:104 → 201
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:14 → 60
      zf-RING_4; RING/Ubox like zinc-binding domain

    4. NM_001164414.2 → NP_001157886.1  CCR4-NOT transcription complex subunit 4 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AC140110
      Consensus CDS
      CCDS51746.1
      UniProtKB/TrEMBL
      E9QA19
      Related
      ENSMUSP00000110640.3, ENSMUST00000114989.9
      Conserved Domains (3) summary
      COG5175
      Location:14 → 322
      MOT2; Transcriptional repressor [Transcription]
      cd12438
      Location:104 → 201
      RRM_CNOT4; RNA recognition motif in Eukaryotic CCR4-NOT transcription complex subunit 4 (NOT4) and similar proteins
      pfam14570
      Location:14 → 60
      zf-RING_4; RING/Ubox like zinc-binding domain

    5. NM_001410682.1 → NP_001397611.1  CCR4-NOT transcription complex subunit 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC140110
      UniProtKB/Swiss-Prot
      Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0

    6. NM_001410683.1 → NP_001397612.1  CCR4-NOT transcription complex subunit 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC140110
      UniProtKB/TrEMBL
      Q3TMD4

    7. NM_001410684.1 → NP_001397613.1  CCR4-NOT transcription complex subunit 4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC140110

    8. NM_001410685.1 → NP_001397614.1  CCR4-NOT transcription complex subunit 4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC140110

    9. NM_001410686.1 → NP_001397615.1  CCR4-NOT transcription complex subunit 4 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC140110

    10. NM_016877.5 → NP_058573.3  CCR4-NOT transcription complex subunit 4 isoform 2

      See identical proteins and their annotated locations for NP_058573.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC140110
      Consensus CDS
      CCDS19999.1
      UniProtKB/Swiss-Prot
      Q8BT14, Q8CCR4, Q9CV74, Q9Z1D0
      Related
      ENSMUSP00000044137.7, ENSMUST00000044163.10
      Conserved Domains (2) summary
      COG5175
      Location:14 → 322
      MOT2; Transcriptional repressor [Transcription]
      pfam08580
      Location:273 → 478
      KAR9; Yeast cortical protein KAR9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      34999000..35110646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BT14.2 GenPept UniProtKB/Swiss-Prot:Q8BT14

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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