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    Mecp2 methyl CpG binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 17257, updated on 10-Dec-2024

    Summary

    Official Symbol
    Mecp2provided by MGI
    Official Full Name
    methyl CpG binding protein 2provided by MGI
    Primary source
    MGI:MGI:99918
    See related
    Ensembl:ENSMUSG00000031393 AllianceGenome:MGI:99918
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mbd5; WBP10; 1500041B07Rik; D630021H01Rik
    Summary
    Enables several functions, including histone reader activity; nucleic acid binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including associative learning; negative regulation of smooth muscle cell differentiation; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including learning or memory; nervous system development; and regulation of gene expression. Located in cytosol; heterochromatin; and nucleus. Is expressed in several structures, including alimentary system; early conceptus; nervous system; paraxial mesenchyme; and sensory organ. Used to study Rett syndrome. Human ortholog(s) of this gene implicated in Rett syndrome; autistic disorder; gastrointestinal system disease; severe congenital encephalopathy due to MECP2 mutation; and syndromic X-linked intellectual disability (multiple). Orthologous to human MECP2 (methyl-CpG binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 8.6), CNS E18 (RPKM 7.6) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mecp2 in Genome Data Viewer
    Location:
    X A7.3; X 37.63 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73070198..73129296, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74026592..74085690, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene interleukin-1 receptor-associated kinase 1 Neighboring gene microRNA 5132 Neighboring gene microRNA 718 Neighboring gene green (M) opsin gene upstream regulatory region Neighboring gene opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan) Neighboring gene testis expressed 28

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded methylated DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded methylated DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded methylated DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded methylated DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables four-way junction DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables four-way junction DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone deacetylase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone reader activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone reader activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables methyl-CpG binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables methyl-CpG binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular condensate scaffold activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular condensate scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables siRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unmethylated CpG binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables unmethylated CpG binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in associative learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within biogenic amine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardiolipin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of catecholamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to isoquinoline alkaloid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to isoquinoline alkaloid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to potassium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to potassium ion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cerebellum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryo development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within epigenetic regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epigenetic regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within genomic imprinting IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within genomic imprinting ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of glial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glucocorticoid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glutamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hippocampus development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within inositol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lung alveolus development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organismal response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of astrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of astrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of blood vessel endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of dendrite extension IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of dendritic spine development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression via chromosomal CpG island methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression via chromosomal CpG island methylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of locomotion involved in locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of locomotion involved in locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of primary miRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of respiratory gaseous exchange IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of respiratory gaseous exchange ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of smooth muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within nervous system process involved in regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular process controlling posture IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in olfactory bulb development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oligodendrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within phosphatidylcholine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of anterograde dense core granule transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of anterograde dense core granule transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of branching morphogenesis of a nerve IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of branching morphogenesis of a nerve ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendrite extension IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic spine development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of glial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of microtubule nucleation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of retrograde dense core granule transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of retrograde dense core granule transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in principal sensory nucleus of trigeminal nerve development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within proprioception IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of action potential firing threshold IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of action potential firing threshold ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of respiratory gaseous exchange by nervous system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within respiratory gaseous exchange by respiratory system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to alcohol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cocaine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cocaine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to ionizing radiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lead ion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to other organism IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in social behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spinal cord development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within startle response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in striatum development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in thalamus development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of trans-synaptic signaling by BDNF IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ventricular cardiac muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within ventricular system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    methyl-CpG-binding protein 2
    Names
    meCp-2 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081979.2NP_001075448.1  methyl-CpG-binding protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, also known as alpha) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK158664, AL672002, BU700810
      Consensus CDS
      CCDS41016.1
      UniProtKB/Swiss-Prot
      Q9Z2D6
      Related
      ENSMUSP00000033770.7, ENSMUST00000033770.13
      Conserved Domains (1) summary
      smart00391
      Location:109186
      MBD; Methyl-CpG binding domain
    2. NM_010788.4NP_034918.1  methyl-CpG-binding protein 2 isoform 2

      See identical proteins and their annotated locations for NP_034918.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, also known as beta) has an additional exon in the 5' region, which results in the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AL672002, BU700810
      Consensus CDS
      CCDS41017.1
      UniProtKB/Swiss-Prot
      B1AUZ2, B1AUZ3, Q3TYG1, Q9Z2D6
      Related
      ENSMUSP00000098314.4, ENSMUST00000100750.10
      Conserved Domains (1) summary
      smart00391
      Location:92169
      MBD; Methyl-CpG binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      73070198..73129296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251240.1XP_030107100.1  methyl-CpG-binding protein 2 isoform X1

      UniProtKB/Swiss-Prot
      B1AUZ2, B1AUZ3, Q3TYG1, Q9Z2D6
      Conserved Domains (1) summary
      smart00391
      Location:92169
      MBD; Methyl-CpG binding domain