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    Rflnb refilin B [ Mus musculus (house mouse) ]

    Gene ID: 76566, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rflnbprovided by MGI
    Official Full Name
    refilin Bprovided by MGI
    Primary source
    MGI:MGI:1923816
    See related
    Ensembl:ENSMUSG00000020846 AllianceGenome:MGI:1923816
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    cfm; Fam101b; RefilinB; 1500005K14Rik
    Summary
    Predicted to enable filamin binding activity. Acts upstream of or within several processes, including actin filament bundle organization; negative regulation of bone mineralization involved in bone maturation; and negative regulation of chondrocyte development. Located in actin filament bundle. Is expressed in several structures, including 1st branchial arch; embryo ectoderm; genital tubercle; lung; and occipital myotome. Orthologous to human RFLNB (refilin B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in stomach adult (RPKM 30.0), colon adult (RPKM 25.7) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Rflnb in Genome Data Viewer
    Location:
    11 B5; 11 45.92 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75910020..75918608, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (76019194..76027782, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12339 Neighboring gene rabphilin 3A-like (without C2 domains) Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:75790377-75790632 Neighboring gene STARR-positive B cell enhancer ABC_E10691 Neighboring gene STARR-seq mESC enhancer starr_30012 Neighboring gene ligand of ATE1 Neighboring gene STARR-seq mESC enhancer starr_30013 Neighboring gene VPS53 GARP complex subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:75920753-75920862 Neighboring gene predicted gene, 46252 Neighboring gene TLC domain containing 3A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables filamin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables filamin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in actin filament bundle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in actin filament bundle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    refilin-B
    Names
    family with sequence similarity 101, member B
    filamin-interacting protein FAM101B
    protein FAM101B
    regulator of filamin protein B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029658.1NP_083934.1  refilin-B

      See identical proteins and their annotated locations for NP_083934.1

      Status: VALIDATED

      Source sequence(s)
      AA016881, AK005164, AL645569, W81812
      Consensus CDS
      CCDS48851.1
      UniProtKB/Swiss-Prot
      Q5SVD0, Q9DB69
      Related
      ENSMUSP00000021207.7, ENSMUST00000021207.7
      Conserved Domains (1) summary
      pfam15068
      Location:1204
      FAM101; FAM101 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      75910020..75918608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)