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    Gls glutaminase [ Mus musculus (house mouse) ]

    Gene ID: 14660, updated on 10-Dec-2024

    Summary

    Official Symbol
    Glsprovided by MGI
    Official Full Name
    glutaminaseprovided by MGI
    Primary source
    MGI:MGI:95752
    See related
    Ensembl:ENSMUSG00000026103 AllianceGenome:MGI:95752
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330442B14; B230365M23Rik
    Summary
    Enables glutaminase activity and identical protein binding activity. Involved in glutamate biosynthetic process; glutamine catabolic process; and protein homotetramerization. Acts upstream of or within chemical synaptic transmission; regulation of respiratory gaseous exchange by nervous system process; and suckling behavior. Predicted to be located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 71. Orthologous to human GLS (glutaminase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 20.0), cortex adult (RPKM 19.9) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Gls in Genome Data Viewer
    Location:
    1 C1.1; 1 26.86 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (52202608..52274168, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (52163449..52235009, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene signal transducer and activator of transcription 4 Neighboring gene STARR-seq mESC enhancer starr_00894 Neighboring gene STARR-positive B cell enhancer ABC_E10010 Neighboring gene predicted gene, 31812 Neighboring gene STARR-positive B cell enhancer ABC_E3272 Neighboring gene STARR-positive B cell enhancer ABC_E3273 Neighboring gene signal transducer and activator of transcription 1 Neighboring gene transmembrane protein 209 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7722 Neighboring gene STARR-positive B cell enhancer ABC_E1992 Neighboring gene predicted gene, 31867 Neighboring gene tripartite motif-containing 75 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glutaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glutaminase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutaminase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables glutaminase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    glutaminase kidney isoform, mitochondrial
    NP_001074550.1
    NP_001106854.1
    XP_006495764.1
    XP_006495765.1
    XP_006495767.1
    XP_017171725.1
    XP_036016518.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081081.2NP_001074550.1  glutaminase kidney isoform, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_001074550.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC123752
      Consensus CDS
      CCDS35561.1
      UniProtKB/Swiss-Prot
      D3Z7P3, E9PUF0, Q69ZX9
      Related
      ENSMUSP00000110158.3, ENSMUST00000114513.9
      Conserved Domains (4) summary
      sd00045
      Location:562588
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:562652
      Ank_2; Ankyrin repeats (3 copies)
      pfam17959
      Location:144227
      EF-hand_14; EF-hand domain
      pfam04960
      Location:249535
      Glutaminase
    2. NM_001113383.1NP_001106854.1  glutaminase kidney isoform, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon, compared to variant 1, resulting in a shorter protein (isoform 2) that has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK173039, BE849049
      Consensus CDS
      CCDS48256.1
      UniProtKB/Swiss-Prot
      D3Z7P3
      Related
      ENSMUSP00000110155.2, ENSMUST00000114510.8
      Conserved Domains (1) summary
      pfam04960
      Location:249535
      Glutaminase; Glutaminase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      52202608..52274168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316236.2XP_017171725.1  glutaminase kidney isoform, mitochondrial isoform X4

      Conserved Domains (3) summary
      sd00045
      Location:224250
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:224314
      Ank_2; Ankyrin repeats (3 copies)
      pfam04960
      Location:9197
      Glutaminase
    2. XM_036160625.1XP_036016518.1  glutaminase kidney isoform, mitochondrial isoform X2

      UniProtKB/TrEMBL
      D3Z7P4
      Conserved Domains (3) summary
      sd00045
      Location:333359
      ANK; ANK repeat [structural motif]
      pfam04960
      Location:20304
      Glutaminase
      pfam12796
      Location:333425
      Ank_2; Ankyrin repeats (3 copies)
    3. XM_006495702.3XP_006495765.1  glutaminase kidney isoform, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006495765.1

      UniProtKB/TrEMBL
      D3Z7P4
      Related
      ENSMUSP00000110157.2, ENSMUST00000114512.8
      Conserved Domains (3) summary
      sd00045
      Location:333359
      ANK; ANK repeat [structural motif]
      pfam04960
      Location:20304
      Glutaminase
      pfam12796
      Location:333425
      Ank_2; Ankyrin repeats (3 copies)
    4. XM_006495701.4XP_006495764.1  glutaminase kidney isoform, mitochondrial isoform X1

      Conserved Domains (2) summary
      pfam17959
      Location:144227
      EF-hand_14; EF-hand domain
      pfam04960
      Location:249535
      Glutaminase
    5. XM_006495704.5XP_006495767.1  glutaminase kidney isoform, mitochondrial isoform X3

      Conserved Domains (2) summary
      pfam17959
      Location:144227
      EF-hand_14; EF-hand domain
      cl00907
      Location:249353
      Glutaminase