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    Ylpm1 YLP motif containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 56531, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ylpm1provided by MGI
    Official Full Name
    YLP motif containing 1provided by MGI
    Primary source
    MGI:MGI:1926195
    See related
    Ensembl:ENSMUSG00000021244 AllianceGenome:MGI:1926195
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZAP; Zap3; A930013E17Rik
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Acts upstream of or within negative regulation of transcription by RNA polymerase II and regulation of telomere maintenance. Located in nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and immune system. Orthologous to human YLPM1 (YLP motif containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 14.2), CNS E11.5 (RPKM 12.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ylpm1 in Genome Data Viewer
    Location:
    12 D1; 12 39.5 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (85042977..85130501)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84996203..85088068)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene apoptosis resistant E3 ubiquitin protein ligase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86311736-86311923 Neighboring gene FCF1 rRNA processing protein Neighboring gene STARR-positive B cell enhancer ABC_E1446 Neighboring gene STARR-seq mESC enhancer starr_32760 Neighboring gene STARR-seq mESC enhancer starr_32761 Neighboring gene STARR-seq mESC enhancer starr_32762 Neighboring gene prospero homeobox 2 opposite strand Neighboring gene prospero homeobox 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86464102-86464289 Neighboring gene dihydrolipoamide S-succinyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The efficacy of zinc finger antiviral protein against hepatitis B virus transcription and replication in tansgenic mouse model. Chen EQ, et al. Virol J, 2015 Feb 13. PMID 25889209, Free PMC Article
    2. ZAP facilitates NLRP3 inflammasome activation via promoting the oligomerization of NLRP3. Qin D, et al. Int Immunopharmacol, 2024 May 30. PMID 38663314
    3. NGF gene expression and secretion in white adipose tissue: regulation in 3T3-L1 adipocytes by hormones and inflammatory cytokines. Peeraully MR, et al. Am J Physiol Endocrinol Metab, 2004 Aug. PMID 15100092
    4. A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation. Armstrong L, et al. Mech Dev, 2004 Dec. PMID 15511642
    5. A method to identify cDNAs based on localization of green fluorescent protein fusion products. Misawa K, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10716735, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZAP facilitates NLRP3 inflammasome activation via promoting the oligomerization of NLRP3.
      Title: ZAP facilitates NLRP3 inflammasome activation via promoting the oligomerization of NLRP3.
    2. ZAP inhibited hepatitis B virus replication in vivo.
      Title: The efficacy of zinc finger antiviral protein against hepatitis B virus transcription and replication in tansgenic mouse model.
    3. Overexpression in murine embryonic stem cells results in reduction in telomerase activity and reduced cell division.
      Title: A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of telomere maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of telomere maintenance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    YLP motif-containing protein 1
    Names
    nuclear protein ZAP
    nuclear protein ZAP3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347421.1 → NP_001334350.1  YLP motif-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.
      Source sequence(s)
      AC127582, AC155811, AK044440, AK087500, BF464857, BM947342, CA328677, CF747026, CR974585
      Consensus CDS
      CCDS88371.1
      UniProtKB/Swiss-Prot
      E9QKY3, Q7TMM4, Q9R0I7
      UniProtKB/TrEMBL
      E9Q803
      Related
      ENSMUSP00000128962.2, ENSMUST00000168977.8

    2. NM_178363.4 → NP_848140.3  YLP motif-containing protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC127582, AC155811, AK044440, AW537032, CF742131, CF747026, CR974585, CV561380
      Consensus CDS
      CCDS49114.1
      UniProtKB/TrEMBL
      D3YWX2
      Related
      ENSMUSP00000021670.9, ENSMUST00000021670.15
      Conserved Domains (1) summary
      pfam13671
      Location:1829 → 1968
      AAA_33; AAA domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      85042977..85130501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516100.4 → XP_006516163.1  YLP motif-containing protein 1 isoform X1

      Conserved Domains (2) summary
      PRK12678
      Location:1081 → 1363
      PRK12678; transcription termination factor Rho; Provisional
      pfam13671
      Location:1798 → 1937
      AAA_33; AAA domain

    RNA

    1. XR_003950069.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0I7.2 GenPept UniProtKB/Swiss-Prot:Q9R0I7

    Gene LinkOut

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