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    Itgae integrin alpha E, epithelial-associated [ Mus musculus (house mouse) ]

    Gene ID: 16407, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Itgaeprovided by MGI
    Official Full Name
    integrin alpha E, epithelial-associatedprovided by MGI
    Primary source
    MGI:MGI:1298377
    See related
    Ensembl:ENSMUSG00000005947 AllianceGenome:MGI:1298377
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD103; aM290; alpha-E1; A530055J10; alpha-M290
    Summary
    Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; lymph node; nasal septum; and nucleus pulposus. Orthologous to human ITGAE (integrin subunit alpha E). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in thymus adult (RPKM 6.0), testis adult (RPKM 5.9) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Itgae in Genome Data Viewer
    Location:
    11 B4; 11 45.22 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72981396..73038272)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (73090505..73147449)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4732414G09 gene Neighboring gene STARR-positive B cell enhancer ABC_E10684 Neighboring gene calcium/calmodulin-dependent protein kinase kinase 1, alpha Neighboring gene STARR-positive B cell enhancer ABC_E5246 Neighboring gene nuclear cap binding subunit 3 Neighboring gene STARR-positive B cell enhancer mm9_chr11:72885264-72885564 Neighboring gene STARR-seq mESC enhancer starr_29927 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72921846-72921999 Neighboring gene STARR-seq mESC enhancer starr_29929 Neighboring gene histone H3 associated protein kinase Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 5 Neighboring gene STARR-positive B cell enhancer ABC_E1141 Neighboring gene Tax1 (human T cell leukemia virus type I) binding protein 3 Neighboring gene ER membrane protein complex subunit 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of CD103+ intestinal dendritic cells during colonic inflammation. Strauch UG, et al. World J Gastroenterol, 2010 Jan 7. PMID 20039445, Free PMC Article
    2. Hypersensitivity pneumonitis onset and severity is regulated by CD103 dendritic cell expression. Bernatchez E, et al. PLoS One, 2017. PMID 28628641, Free PMC Article
    3. Murine CD103(+) dendritic cells protect against steatosis progression towards steatohepatitis. Heier EC, et al. J Hepatol, 2017 Jun. PMID 28108233
    4. Murine CMV Infection Induces the Continuous Production of Mucosal Resident T Cells. Smith CJ, et al. Cell Rep, 2015 Nov 10. PMID 26526996, Free PMC Article
    5. Integrin αE(CD103) Is Involved in Regulatory T-Cell Function in Allergic Contact Hypersensitivity. Braun A, et al. J Invest Dermatol, 2015 Dec. PMID 26203637

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Escherichia coli adhesion protein FimH exacerbates colitis via CD11b[+]CD103[-] dendritic cell activation.
      Title: Escherichia coli adhesion protein FimH exacerbates colitis via CD11b(+)CD103(-) dendritic cell activation.
    2. Immunological characteristics of CD103[+]CD8[+] Tc cells in the liver of C57BL/6 mouse infected with plasmodium NSM.
      Title: Immunological characteristics of CD103(+)CD8(+) Tc cells in the liver of C57BL/6 mouse infected with plasmodium NSM.
    3. CD103 Regulates Dermal Regulatory T Cell Motility and Interactions with CD11c-Expressing Leukocytes to Control Skin Inflammation.
      Title: CD103 Regulates Dermal Regulatory T Cell Motility and Interactions with CD11c-Expressing Leukocytes to Control Skin Inflammation.
    4. gammadelta Intraepithelial Lymphocytes Facilitate Pathological Epithelial Cell Shedding Via CD103-Mediated Granzyme Release.
      Title: γδ Intraepithelial Lymphocytes Facilitate Pathological Epithelial Cell Shedding Via CD103-Mediated Granzyme Release.
    5. Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal.
      Title: Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal.
    6. Dual targeting of lymphocyte homing and retention through alpha4beta7 and alphaEbeta7 inhibition in inflammatory bowel disease.
      Title: Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease.
    7. The molecular basis and cellular effects of distinct CD103 expression on CD4 and CD8 T cells.
      Title: The molecular basis and cellular effects of distinct CD103 expression on CD4 and CD8 T cells.
    8. Lung CD103(+) Dendritic cells of mice infected with Paracoccidioides brasiliensis contribute to Treg differentiation.
      Title: Lung CD103(+) Dendritic cells of mice infected with Paracoccidioides brasiliensis contribute to Treg differentiation.
    9. Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells.
      Title: Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells.
    10. CD103(+) cDC1 and endogenous CD8(+) T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.
      Title: CD103(+) cDC1 and endogenous CD8(+) T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.
    Submit: New GeneRIF Correction See all GeneRIFs (65)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC183601

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    integrin alpha-E
    Names
    integrin alpha M290

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361245.2 → NP_001348174.1  integrin alpha-E isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL670399
      UniProtKB/TrEMBL
      Q3U4V9
      Conserved Domains (3) summary
      smart00191
      Location:565 → 624
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:195 → 370
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam08441
      Location:667 → 938
      Integrin_alpha2; Integrin alpha

    2. NM_008399.4 → NP_032425.2  integrin alpha-E isoform 1 precursor

      See identical proteins and their annotated locations for NP_032425.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL670399
      Consensus CDS
      CCDS24995.1
      UniProtKB/Swiss-Prot
      B1AUD5, Q60677
      UniProtKB/TrEMBL
      A2T0Z1, Q3U4V9
      Related
      ENSMUSP00000006101.4, ENSMUST00000006101.4
      Conserved Domains (3) summary
      smart00191
      Location:566 → 625
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:196 → 371
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam08441
      Location:668 → 939
      Integrin_alpha2; Integrin alpha

    RNA

    1. NR_189133.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL670399

    2. NR_189134.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL670399

    3. NR_189135.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL670399

    4. NR_189136.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL670399

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      72981396..73038272
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172944.2: Suppressed sequence

      Description
      NM_172944.2: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60677.2 GenPept UniProtKB/Swiss-Prot:Q60677

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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