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    Serpina1f serine (or cysteine) peptidase inhibitor, clade A, member 1F [ Mus musculus (house mouse) ]

    Gene ID: 68348, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Serpina1fprovided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade A, member 1Fprovided by MGI
    Primary source
    MGI:MGI:1915598
    See related
    Ensembl:ENSMUSG00000021081 AllianceGenome:MGI:1915598
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    epserin; Serpina2; 0610012A11Rik
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in endoplasmic reticulum. Predicted to be active in extracellular space. Orthologous to human SERPINA2 (serpin family A member 2 (gene/pseudogene)). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward genital fat pad adult (RPKM 310.1) See more
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    Genomic context

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    See Serpina1f in Genome Data Viewer
    Location:
    12 E; 12 52.98 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (103654303..103661788, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (103688044..103695529, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 6 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 16 Neighboring gene predicted gene, 46373 Neighboring gene serine (or cysteine) preptidase inhibitor, clade A, member 1B pseudogene Neighboring gene serine (or cysteine) preptidase inhibitor, clade A, member 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of novel and unknown mouse epididymis-specific genes by complementary DNA microarray technology. Yamazaki K, et al. Biol Reprod, 2006 Sep. PMID 16707773
    2. Update of the human and mouse SERPIN gene superfamily. Heit C, et al. Hum Genomics, 2013 Oct 30. PMID 24172014, Free PMC Article
    3. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1-antitrypsin 1-6
    Names
    alpha-1 protease inhibitor 6
    alpha-1-antiproteinase
    epididymal serine protease inhibitor
    epsin
    serine protease inhibitor 1-6
    serine protease inhibitor A1f
    serpin A1f

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164742.1 → NP_001158214.1  alpha-1-antitrypsin 1-6 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK002574, AK165409
      Consensus CDS
      CCDS49155.1
      UniProtKB/TrEMBL
      E9PUC6, Q08EA5
      Related
      ENSMUSP00000112533.2, ENSMUST00000117053.8
      Conserved Domains (1) summary
      cl00137
      Location:55 → 351
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    2. NM_026687.2 → NP_080963.2  alpha-1-antitrypsin 1-6 isoform 1 precursor

      See identical proteins and their annotated locations for NP_080963.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC098741, AK002574, AK165409
      Consensus CDS
      CCDS26137.1
      UniProtKB/TrEMBL
      G3X9Z5, Q08EA5
      Related
      ENSMUSP00000021490.6, ENSMUST00000021490.12
      Conserved Domains (1) summary
      pfam00079
      Location:48 → 409
      Serpin; Serpin (serine protease inhibitor)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      103654303..103661788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DCQ7.1 GenPept UniProtKB/Swiss-Prot:Q9DCQ7

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