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    LOC128925931 STARR-positive B cell enhancer ABC_E6649 [ Mus musculus (house mouse) ]

    Gene ID: 128925931, updated on 8-Feb-2024

    Summary

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    Gene symbol
    LOC128925931
    Gene description
    STARR-positive B cell enhancer ABC_E6649
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rr368551
    Summary
    This genomic region was identified as a putative B cell regulatory element by FAIRE-seq (formaldehyde-assisted isolation of regulatory elements sequencing), and was validated as an enhancer by STARR-seq (self-transcribing active regulatory region sequencing) in lipopolysaccharide-activated mouse splenic B cells. A subregion was identified as a candidate cis-regulatory module (CRM) in developing mouse thymocytes based on a combination of DNase I hypersensitivity and transcription factor binding. That CRM was validated as an active enhancer by high-throughput CapStarr-seq reporter assays showing weak activity in NIH3T3 fibroblasts. [provided by RefSeq, Oct 2023]
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    Genomic context

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    See LOC128925931 in Genome Data Viewer
    Location:
    chromosome: 8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71229751..71230052)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6330537M06 gene Neighboring gene interferon gamma inducible protein 30 Neighboring gene STARR-positive B cell enhancer ABC_E10506 Neighboring gene phosphoinositide-3-kinase regulatory subunit 2 Neighboring gene RIKEN cDNA 2010320M18 gene Neighboring gene STARR-positive B cell enhancer ABC_E8241 Neighboring gene microtubule associated serine/threonine kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E2265 Neighboring gene microRNA 7240 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:73330531-73330714 Neighboring gene interleukin 12 receptor, beta 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-throughput and quantitative assessment of enhancer activity in mammals by CapStarr-seq. Vanhille L, et al. Nat Commun, 2015 Apr 15. PMID 25872643
    2. Gene regulatory networks STARR-ing B cells. Martínez de Paz A, et al. Nat Immunol, 2020 Feb. PMID 31873293, Free PMC Article
    3. Charting the cis-regulome of activated B cells by coupling structural and functional genomics. Chaudhri VK, et al. Nat Immunol, 2020 Feb. PMID 31873292

    GeneRIFs: Gene References Into Functions

    General gene information

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    Other Names

    • CapStarr-seq enhancer MGSCv37_chr8:73301078-73301261
    • regulatory region 368551

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_151590.2 

      Range
      101..402
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71229751..71230052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version