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    Slc29a4 solute carrier family 29 (nucleoside transporters), member 4 [ Mus musculus (house mouse) ]

    Gene ID: 243328, updated on 27-Nov-2024

    Summary

    Official Symbol
    Slc29a4provided by MGI
    Official Full Name
    solute carrier family 29 (nucleoside transporters), member 4provided by MGI
    Primary source
    MGI:MGI:2385330
    See related
    Ensembl:ENSMUSG00000050822 AllianceGenome:MGI:2385330
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ENT4; PMAT; mENT4; mPMAT
    Summary
    Enables several functions, including monoamine transmembrane transporter activity; neurotransmitter transmembrane transporter activity; and toxin transmembrane transporter activity. Involved in several processes, including adenosine transport; monoamine transport; and xenobiotic transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including brain; eye; reproductive system; spinal cord; and trigeminal nerve. Orthologous to human SLC29A4 (solute carrier family 29 member 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 34.0), CNS E14 (RPKM 29.0) and 11 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Slc29a4 in Genome Data Viewer
    Location:
    5 G2; 5 81.56 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (142678226..142708245)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (142692478..142722490)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10363 Neighboring gene predicted gene, 31274 Neighboring gene WD repeat domain, phosphoinositide interacting 2 Neighboring gene STARR-seq mESC enhancer starr_14752 Neighboring gene predicted gene, 40352 Neighboring gene trinucleotide repeat containing 18 Neighboring gene STARR-seq mESC enhancer starr_14754 Neighboring gene STARR-seq mESC enhancer starr_14759 Neighboring gene STARR-seq mESC enhancer starr_14762 Neighboring gene predicted gene, 31365 Neighboring gene predicted gene 15770

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC38048

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables efflux transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables efflux transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables monoamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables monoamine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables monoamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables monoamine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables monoatomic cation transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables neurotransmitter transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables neurotransmitter transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables neurotransmitter transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables nucleoside transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables organic acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables organic acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables organic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables organic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables toxin transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables xenobiotic transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in adenosine transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenosine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular detoxification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dopamine transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dopamine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dopamine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dopamine uptake IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dopamine uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epinephrine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epinephrine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in epinephrine uptake IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epinephrine uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in export across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histamine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histamine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in histamine uptake IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histamine uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoamine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoatomic cation transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurotransmitter transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurotransmitter transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in norepinephrine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in norepinephrine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in norepinephrine uptake IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in norepinephrine uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleoside transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in organic acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in organic acid transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in organic cation transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in serotonin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in serotonin transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in serotonin transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in serotonin uptake IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in serotonin uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in xenobiotic transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    equilibrative nucleoside transporter 4
    Names
    plasma membrane monoamine transporter
    solute carrier family 29 member 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424729.1NP_001411658.1  equilibrative nucleoside transporter 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC240265
      UniProtKB/Swiss-Prot
      Q8R139
    2. NM_001424730.1NP_001411659.1  equilibrative nucleoside transporter 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC240265
    3. NM_001424731.1NP_001411660.1  equilibrative nucleoside transporter 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC240265
    4. NM_146257.3NP_666369.1  equilibrative nucleoside transporter 4 isoform 1

      See identical proteins and their annotated locations for NP_666369.1

      Status: VALIDATED

      Source sequence(s)
      AC240265
      Consensus CDS
      CCDS39364.1
      UniProtKB/Swiss-Prot
      Q8R139
      Related
      ENSMUSP00000059896.8, ENSMUST00000058418.8
      Conserved Domains (1) summary
      cl15430
      Location:75498
      Nucleoside_tran; Nucleoside transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      142678226..142708245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165132.1XP_036021025.1  equilibrative nucleoside transporter 4 isoform X2

      Conserved Domains (1) summary
      cl15430
      Location:29343
      Nucleoside_tran; Nucleoside transporter