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    FGFR1 fibroblast growth factor receptor 1 [ Bos taurus (domestic cattle) ]

    Gene ID: 281768, updated on 30-Jan-2025

    Summary

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    Official Symbol
    FGFR1provided by VGNC
    Official Full Name
    fibroblast growth factor receptor 1provided by VGNC
    Primary source
    VGNC:VGNC:50179
    See related
    BGD:BT11580; EnsemblRapid:ENSBTAG00070020945
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See FGFR1 in Genome Data Viewer
    Location:
    chromosome: 27
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 27 NC_037354.1 (33548428..33599029, complement)

    Chromosome 27 - NC_037354.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor binding SET domain protein 3 Neighboring gene microRNA mir-2400 Neighboring gene LETM1 domain-containing protein LETM2, mitochondrial Neighboring gene leucine zipper and EF-hand containing transmembrane protein 2 Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene transfer RNA glycine (anticodon UCC)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037354.1 Chromosome 27 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Heparan sulphate glycosaminoglycans derived from endothelial cells and smooth muscle cells differentially modulate fibroblast growth factor-2 biological activity through fibroblast growth factor receptor-1. Berry D, et al. Biochem J, 2003 Jul 1. PMID 12659634, Free PMC Article
    2. Stimulatory effects of fibroblast growth factor 2 on proliferation and migration of uterine luminal epithelial cells during early pregnancy. Lim W, et al. Biol Reprod, 2017 Jan 1. PMID 28395342
    3. Somatic cell nuclear transfer is associated with altered expression of angiogenic factor systems in bovine placentomes at term. Campos DB, et al. Genet Mol Res, 2010 Feb 23. PMID 20198587
    4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. activation of FGFR1 and FGFR2 by uterine- and endometrial-derived FGF2 stimulates PI3K/AKT and mitogen-activated protein kinase pathways for development of the porcine uterus and improvement of litter size
      Title: Stimulatory effects of fibroblast growth factor 2 on proliferation and migration of uterine luminal epithelial cells during early pregnancy.
    2. Alterations in the expression of VEGF-A and bFGF systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
      Title: Somatic cell nuclear transfer is associated with altered expression of angiogenic factor systems in bovine placentomes at term.
    3. Heparan sulfate glycosaminoglycans affect FGF signalling by interacting with both the growth factor and the receptor
      Title: Heparan sulphate glycosaminoglycans derived from endothelial cells and smooth muscle cells differentially modulate fibroblast growth factor-2 biological activity through fibroblast growth factor receptor-1.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC151817

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables fibroblast growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fibroblast growth factor receptor 1
    Names
    fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)
    NP_001103677.1
    XP_010818626.1
    XP_024841961.1
    XP_024841962.1
    XP_059738149.1
    XP_059738150.1
    XP_059738151.1
    XP_059738152.1
    XP_059738153.1
    XP_059738155.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110207.1 → NP_001103677.1  fibroblast growth factor receptor 1 precursor

      See identical proteins and their annotated locations for NP_001103677.1

      Status: PROVISIONAL

      Source sequence(s)
      BC134637
      UniProtKB/TrEMBL
      A0A3Q1LUE0, A4IFL5, F1MKA3
      Related
      ENSBTAP00070028265.1, ENSBTAT00070047259.1
      Conserved Domains (7) summary
      cd04973
      Location:40 → 118
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd04974
      Location:268 → 357
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161 → 245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00410
      Location:260 → 356
      IG_like; Immunoglobulin like
      pfam07679
      Location:158 → 245
      I-set; Immunoglobulin I-set domain
      cd05098
      Location:462 → 763
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      pfam07714
      Location:476 → 752
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037354.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      33548428..33599029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024986194.2 → XP_024841962.1  fibroblast growth factor receptor 1 isoform X7

      UniProtKB/TrEMBL
      A0A3Q1MDS3
      Related
      ENSBTAP00070028304.1, ENSBTAT00070047327.1
      Conserved Domains (3) summary
      cd05857
      Location:72 → 156
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:179 → 268
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05098
      Location:371 → 672
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1

    2. XM_059882170.1 → XP_059738153.1  fibroblast growth factor receptor 1 isoform X6

      UniProtKB/TrEMBL
      A0A3Q1MDS3

    3. XM_059882169.1 → XP_059738152.1  fibroblast growth factor receptor 1 isoform X5

      UniProtKB/TrEMBL
      A0A3Q1MDS3

    4. XM_024986193.2 → XP_024841961.1  fibroblast growth factor receptor 1 isoform X4

      UniProtKB/TrEMBL
      A0A3Q1LUE0
      Conserved Domains (4) summary
      cd04973
      Location:40 → 118
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:161 → 245
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      cd05858
      Location:268 → 357
      Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
      cd05098
      Location:460 → 761
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1

    5. XM_059882168.1 → XP_059738151.1  fibroblast growth factor receptor 1 isoform X3

      UniProtKB/TrEMBL
      A0A3Q1LUE0, A4IFL5, F1MKA3

    6. XM_010820324.4 → XP_010818626.1  fibroblast growth factor receptor 1 isoform X2

      UniProtKB/TrEMBL
      A0A3Q1LUE0
      Conserved Domains (7) summary
      cd04973
      Location:40 → 118
      Ig1_FGFR; First immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd04974
      Location:270 → 359
      Ig3_FGFR; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor (FGFR)
      cd05857
      Location:163 → 247
      Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
      smart00410
      Location:262 → 358
      IG_like; Immunoglobulin like
      pfam07679
      Location:160 → 247
      I-set; Immunoglobulin I-set domain
      cd05098
      Location:462 → 763
      PTKc_FGFR1; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1
      pfam07714
      Location:476 → 752
      Pkinase_Tyr; Protein tyrosine kinase

    7. XM_059882166.1 → XP_059738149.1  fibroblast growth factor receptor 1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LUE0, A0AAF6DM05

    8. XM_059882172.1 → XP_059738155.1  fibroblast growth factor receptor 1 isoform X6

      UniProtKB/TrEMBL
      A0A3Q1MDS3

    9. XM_059882167.1 → XP_059738150.1  fibroblast growth factor receptor 1 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1LUE0, A0AAF6DM05
    Nucleotide Protein Strain
    Heading Accession and Version

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