Trpm7 transient receptor potential cation channel, subfamily M, member 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trpm7provided by MGI
Official Full Name: transient receptor potential cation channel, subfamily M, member 7provided by MGI
Primary source: MGI:MGI:1929996
See related: Ensembl:ENSMUSG00000027365 AllianceGenome:MGI:1929996
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CHAK; CHAK1; Ltpr7; Ltrpc7; LTrpC-7; TRPPLIK; 2310022G15Rik; 4833414K03Rik; 5033407O22Rik
Summary: Enables cytoskeletal protein binding activity; metal ion transmembrane transporter activity; and protein kinase activity. Involved in intracellular magnesium ion homeostasis; metal ion transport; and protein homotetramerization. Acts upstream of or within several processes, including actomyosin structure organization; calcium-dependent cell-matrix adhesion; and protein autophosphorylation. Located in several cellular components, including cytoplasmic vesicle; nucleus; and ruffle. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and skin. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1. Orthologous to human TRPM7 (transient receptor potential cation channel subfamily M member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 10.3), CNS E11.5 (RPKM 10.0) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 61.76 cM

Exon count:: 42

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (126633478..126718181, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (126791558..126876261, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Essential role of Mg[2+] in mouse preimplantation embryo development revealed by TRPM7 chanzyme-deficient gametes.
Title: Essential role of Mg(2+) in mouse preimplantation embryo development revealed by TRPM7 chanzyme-deficient gametes.
Ischemia-Reperfusion Increases TRPM7 Expression in Mouse Retinas.
Title: Ischemia-Reperfusion Increases TRPM7 Expression in Mouse Retinas.
TRPM7 kinase activity induces amyloid-beta degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer's disease.
Title: TRPM7 kinase activity induces amyloid-β degradation to reverse synaptic and cognitive deficits in mouse models of Alzheimer's disease.
TRPM7 Kinase Domain is Part of the Rac1-SSH2-cofilin Complex Regulating F-actin in the Mouse Nervous System.
Title: TRPM7 Kinase Domain is Part of the Rac1-SSH2-cofilin Complex Regulating F-actin in the Mouse Nervous System.
TRPM7 kinase mediates hypomagnesemia-induced seizure-related death.
Title: TRPM7 kinase mediates hypomagnesemia-induced seizure-related death.
Effect of truncation on TRPM7 channel activity.
Title: Effect of truncation on TRPM7 channel activity.
Conditional knockout of transient receptor potential melastatin 7 in the enamel epithelium: Effects on enamel formation.
Title: Conditional knockout of transient receptor potential melastatin 7 in the enamel epithelium: Effects on enamel formation.
TRPM7 kinase is required for insulin production and compensatory islet responses during obesity.
Title: TRPM7 kinase is required for insulin production and compensatory islet responses during obesity.
Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice.
Title: Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice.
TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies.
Title: TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies.

Submit: New GeneRIF Correction See all GeneRIFs (98)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Gene trapped (1) 1 citation
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128920 (e-PCR)
- UniSTS:212228

Trpm7 (e-PCR), detects polymorphism
- UniSTS:531252

BB103613 (e-PCR)
- UniSTS:185495

Trpm7 (e-PCR), detects polymorphism
- UniSTS:530855

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables myosin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actomyosin structure organization	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium-dependent cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular magnesium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular magnesium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in magnesium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in necroptotic process	ISO Inferred from Sequence Orthology more info
involved_in necroptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homotetramerization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in zinc ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in varicosity	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transient receptor potential cation channel subfamily M member 7

Names: channel-kinase 1; long transient receptor potential channel 7; transient receptor potential M7; transient receptor potential-phospholipase C-interacting kinase; transient receptor potential-related protein, ChaK

NP_001157797.1

EC 2.7.11.1

NP_067425.2

EC 2.7.11.1

XP_036018328.1

EC 2.7.11.1

XP_036018329.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164325.1 → NP_001157797.1 transient receptor potential cation channel subfamily M member 7 isoform 2

See identical proteins and their annotated locations for NP_001157797.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.

Source sequence(s)

AL732330

Consensus CDS

CCDS50700.1

UniProtKB/TrEMBL

A2AI57, B9EK83

Related

ENSMUSP00000028843.6, ENSMUST00000028843.12

Conserved Domains (3) summary

smart00811
Location:1595 → 1813

Alpha_kinase; Alpha-kinase family

pfam00520
Location:879 → 1100

Ion_trans; Ion transport protein

pfam16519
Location:1198 → 1249

TRPM_tetra; Tetramerization domain of TRPM
NM_021450.2 → NP_067425.2 transient receptor potential cation channel subfamily M member 7 isoform 1

See identical proteins and their annotated locations for NP_067425.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL732330

Consensus CDS

CCDS16689.1

UniProtKB/Swiss-Prot

A2AI58, Q8C7S7, Q8CE54, Q921Y5, Q923J1, Q925B2, Q9CUT2, Q9JLQ1

UniProtKB/TrEMBL

B9EK83

Related

ENSMUSP00000099513.4, ENSMUST00000103224.10

Conserved Domains (3) summary

smart00811
Location:1596 → 1814

Alpha_kinase; Alpha-kinase family

pfam00520
Location:879 → 1100

Ion_trans; Ion transport protein

pfam16519
Location:1198 → 1249

TRPM_tetra; Tetramerization domain of TRPM

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

126633478..126718181 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162435.1 → XP_036018328.1 transient receptor potential cation channel subfamily M member 7 isoform X1

UniProtKB/TrEMBL

B9EK83

Conserved Domains (4) summary

TIGR00870
Location:663 → 1113

trp; transient-receptor-potential calcium channel protein

cd16971
Location:1519 → 1757

Alpha_kinase_ChaK1_TRMP7; Alpha-kinase domain of channel kinase 1, also called transient receptor potential cation channel subfamily M member 7

pfam16519
Location:1135 → 1188

TRPM_tetra; Tetramerisation domain of TRPM

pfam18139
Location:47 → 312

LSDAT_euk; SLOG in TRPM
XM_036162436.1 → XP_036018329.1 transient receptor potential cation channel subfamily M member 7 isoform X2

Conserved Domains (3) summary

TIGR00870
Location:722 → 1172

trp; transient-receptor-potential calcium channel protein

pfam16519
Location:1194 → 1247

TRPM_tetra; Tetramerisation domain of TRPM

pfam18139
Location:106 → 371

LSDAT_euk; SLOG in TRPM