tamm41 TAM41 mitochondrial translocator assembly and maintenance homolog [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tamm41provided by ZNC
Official Full Name: TAM41 mitochondrial translocator assembly and maintenance homologprovided by ZNC
Primary source: ZFIN:ZDB-GENE-051030-99
See related: Ensembl:ENSDARG00000100157 AllianceGenome:ZFIN:ZDB-GENE-051030-99
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: TAM41; zgc:123195
Summary: Predicted to enable phosphatidate cytidylyltransferase activity. Predicted to be involved in CDP-diacylglycerol biosynthetic process and cardiolipin biosynthetic process. Predicted to act upstream of or within phospholipid biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be extrinsic component of mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in heart and heart tube. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 56. Orthologous to human TAMM41 (TAM41 mitochondrial translocator assembly and maintenance homolog). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (779735..790304)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (753268..763806)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TAMM41 is required for heart valve differentiation via regulation of PINK-PARK2 dependent mitophagy.
Title: TAMM41 is required for heart valve differentiation via regulation of PINK-PARK2 dependent mitophagy.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidate cytidylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidate cytidylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidate cytidylyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CDP-diacylglycerol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in CDP-diacylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cardiolipin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiolipin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cardiolipin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extrinsic component of mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidate cytidylyltransferase, mitochondrial

Names: CDP-DAG synthase; CDP-diacylglycerol synthase; MMP37-like protein, mitochondrial; TAM41, mitochondrial translocator assembly and maintenance protein, homolog; mitochondrial translocator assembly and maintenance protein 41 homolog

NP_001032196.2

EC 2.7.7.41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.