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    Tcl1 T cell lymphoma breakpoint 1 [ Mus musculus (house mouse) ]

    Gene ID: 21432, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tcl1provided by MGI
    Official Full Name
    T cell lymphoma breakpoint 1provided by MGI
    Primary source
    MGI:MGI:1097166
    See related
    Ensembl:ENSMUSG00000041359 AllianceGenome:MGI:1097166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tcl1a
    Summary
    Predicted to enable identical protein binding activity; protein kinase binding activity; and protein serine/threonine kinase activator activity. Involved in activation of protein kinase B activity. Acts upstream of or within negative regulation of gene expression; regulation of stem cell population maintenance; and somatic stem cell population maintenance. Located in cell cortex; ooplasm; and pronucleus. Is expressed in several structures, including early conceptus; hemolymphoid system gland; liver; and seminiferous cord. Orthologous to human TCL1A (TCL1 family AKT coactivator A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward ovary adult (RPKM 9.8) See more
    Orthologs
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    Genomic context

    See Tcl1 in Genome Data Viewer
    Location:
    12 E; 12 55.28 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (105183012..105188996, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (105216753..105222737, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene T cell leukemia/lymphoma 1B, 3 Neighboring gene T cell leukemia/lymphoma 1B, 4 Neighboring gene STARR-seq mESC enhancer starr_33171 Neighboring gene predicted gene, 53762 Neighboring gene predicted gene, 53763 Neighboring gene STARR-seq mESC enhancer starr_33174 Neighboring gene STARR-seq mESC enhancer starr_33176

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ooplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    T-cell leukemia/lymphoma protein 1A
    Names
    TCL-1
    oncogene TCL-1
    oncogene TCL1
    protein p14 TCL1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289468.1NP_001276397.1  T-cell leukemia/lymphoma protein 1A isoform 2

      See identical proteins and their annotated locations for NP_001276397.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a longer and distinct C-terminus.
      Source sequence(s)
      AK149361, DV653827, DV660020
      Consensus CDS
      CCDS70418.1
      UniProtKB/TrEMBL
      Q3UES7
      Related
      ENSMUSP00000098632.4, ENSMUST00000101071.4
      Conserved Domains (1) summary
      pfam01840
      Location:198
      TCL1_MTCP1; TCL1/MTCP1 family
    2. NM_001309484.1NP_001296413.1  T-cell leukemia/lymphoma protein 1A isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate internal exon and contains an alternate internal exon, resulting in the use of an alternate start codon, compared to variant 2. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      CJ087217, DV646075, DV649899, DV653827, DV660020
    3. NM_001309485.1NP_001296414.1  T-cell leukemia/lymphoma protein 1A isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in its 3' coding region and contains an alternate internal exon, resulting in a frameshift and an early stop codon, compared to variant 2. The encoded isoform (4) has a shorter and distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      CA558861, DV646075, DV653827, DV655843, DV660020
      Consensus CDS
      CCDS83999.1
      UniProtKB/TrEMBL
      H3BJP6
      Related
      ENSMUSP00000135069.2, ENSMUST00000176579.2
      Conserved Domains (1) summary
      pfam01840
      Location:180
      TCL1_MTCP1; TCL1/MTCP1 family
    4. NM_009337.3NP_033363.1  T-cell leukemia/lymphoma protein 1A isoform 1

      See identical proteins and their annotated locations for NP_033363.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AK163387, BC052336, DV653827
      Consensus CDS
      CCDS36549.1
      UniProtKB/Swiss-Prot
      P56280
      UniProtKB/TrEMBL
      H3BJA0
      Related
      ENSMUSP00000036066.9, ENSMUST00000041316.15
      Conserved Domains (1) summary
      pfam01840
      Location:1110
      TCL1_MTCP1; TCL1/MTCP1 family

    RNA

    1. NR_110339.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      CJ087554, DV648028, DV653827, DV660020, DV663230

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      105183012..105188996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)