fbln1 fibulin 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fbln1provided by ZNC
Official Full Name: fibulin 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-73
See related: Ensembl:ENSDARG00000103311 AllianceGenome:ZFIN:ZDB-GENE-990415-73
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: FIBL-1; fbln1c; fbln1d; wu:fc52c06
Summary: Predicted to enable calcium ion binding activity and peptidase activator activity. Acts upstream of or within several processes, including embryonic medial fin morphogenesis; mesenchymal cell migration; and skin morphogenesis. Predicted to be located in extracellular region. Is expressed in several structures, including atrioventricular canal; caudal fin; median fin fold; mesoderm; and tail bud. Orthologous to human FBLN1 (fibulin 1). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (1732838..1808080)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (1598567..1633199)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_003336196.1 (1..29657, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Osteoblast Transcriptome in Developing Zebrafish Reveals Key Roles for Extracellular Matrix Proteins Col10a1a and Fbln1 in Skeletal Development and Homeostasis.
Title: The Osteoblast Transcriptome in Developing Zebrafish Reveals Key Roles for Extracellular Matrix Proteins Col10a1a and Fbln1 in Skeletal Development and Homeostasis.
hmcn2, like fibulin 1 (fbln1), another member of the fibulin family, is predominantly expressed in fin mesenchymal cells and developing somites, contrasting the strict epithelial expression of hmcn1.
Title: Hemicentin 2 and Fibulin 1 are required for epidermal-dermal junction formation and fin mesenchymal cell migration during zebrafish development.

Submit: New GeneRIF Correction

General gene information

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Markers

fbln1c (e-PCR)
- UniSTS:186955

fc52c06 (e-PCR)
- UniSTS:189308

fibl1c (e-PCR)
- UniSTS:204678

fibl1c (e-PCR)
- UniSTS:204679

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables peptidase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in animal organ development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryo development ending in birth or egg hatching	IEP Inferred from Expression Pattern more info
acts_upstream_of_or_within embryonic medial fin morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extracellular matrix organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extracellular matrix organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IEP Inferred from Expression Pattern more info
acts_upstream_of_or_within mesenchymal cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skin morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fibulin-1

Names: fibulin 1C; fibulin 1D; fibulin-1 C varible region

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131042.2 → NP_571117.2 fibulin-1 precursor

See identical proteins and their annotated locations for NP_571117.2

Status: PROVISIONAL

Source sequence(s)

BC162604

UniProtKB/TrEMBL

B3DH18

Related

ENSDARP00000136402.2, ENSDART00000168161.2

Conserved Domains (5) summary

smart00179
Location:332 → 363

EGF_CA; Calcium-binding EGF-like domain

pfam07645
Location:500 → 540

EGF_CA; Calcium-binding EGF domain

pfam12662
Location:479 → 503

cEGF; Complement Clr-like EGF-like

cl00032
Location:19 → 72

ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...

cl21504
Location:192 → 235

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...