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    GAS5 growth arrest specific 5 [ Homo sapiens (human) ]

    Gene ID: 60674, updated on 10-Dec-2024

    Summary

    Official Symbol
    GAS5provided by HGNC
    Official Full Name
    growth arrest specific 5provided by HGNC
    Primary source
    HGNC:HGNC:16355
    See related
    Ensembl:ENSG00000234741 MIM:608280; AllianceGenome:HGNC:16355
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SNHG2; NCRNA00030
    Summary
    This gene produces a spliced long non-coding RNA and is a member of the 5' terminal oligo-pyrimidine class of genes. It is a small nucleolar RNA host gene, containing multiple C/D box snoRNA genes in its introns. Part of the secondary RNA structure of the encoded transcript mimics glucocorticoid response element (GRE) which means it can bind to the DNA binding domain of the glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1). This action blocks the glucocorticoid receptor from being activated and thereby stops it from regulating the transcription of its target genes. This transcript is also thought to regulate the transcriptional activity of other receptors, such as androgen, progesterone and mineralocorticoid receptors, that can bind to its GRE mimic region. Multiple functions have been associated with this transcript, including cellular growth arrest and apoptosis. It has also been identified as a potential tumor suppressor, with its down-regulation associated with cancer in multiple different tissues. [provided by RefSeq, Mar 2015]
    Expression
    Ubiquitous expression in ovary (RPKM 307.5), thyroid (RPKM 113.4) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GAS5 in Genome Data Viewer
    Location:
    1q25.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (173863901..173869045, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (173222019..173227165, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (173833039..173838183, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 160 Neighboring gene MPRA-validated peak463 silencer Neighboring gene centromere protein L Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2116 Neighboring gene H3K27ac hESC enhancers GRCh37_chr1:173793515-173794033 and GRCh37_chr1:173794034-173794551 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:173795193-173795706 Neighboring gene aspartyl-tRNA synthetase 2, mitochondrial Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:173821280-173822182 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:173830052-173830768 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:173830769-173831485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1556 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:173837597-173838796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2118 Neighboring gene GAS5 antisense RNA 1 Neighboring gene small nucleolar RNA, C/D box 81 Neighboring gene small nucleolar RNA, C/D box 47 Neighboring gene small nucleolar RNA, H/ACA box 103 Neighboring gene small nucleolar RNA, C/D box 80 Neighboring gene small nucleolar RNA, C/D box 79 Neighboring gene small nucleolar RNA, C/D box 78 Neighboring gene small nucleolar RNA, C/D box 44 Neighboring gene small nucleolar RNA, C/D box 77 Neighboring gene small nucleolar RNA, C/D box 76 Neighboring gene small nucleolar RNA, C/D box 75 Neighboring gene small nucleolar RNA, C/D box 74 Neighboring gene zinc finger and BTB domain containing 37 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:173863193-173864392 Neighboring gene serpin family C member 1 Neighboring gene uncharacterized LOC124904457 Neighboring gene RNA, 5S ribosomal pseudogene 67

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: CENPL

    Other Names

    • growth arrest specific 5 (non-protein coding)
    • growth arrest specific transcript 5
    • small nucleolar RNA host gene (non-protein coding) 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_002578.4 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000687189.2
    2. NR_152521.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000430245.5
    3. NR_152522.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000686995.2
    4. NR_152523.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000689238.2
    5. NR_152524.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000689958.2
    6. NR_152525.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827949.1
    7. NR_152526.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000693348.2
    8. NR_152527.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000687435.2
    9. NR_152528.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000687549.1
    10. NR_152529.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000449289.8
    11. NR_152530.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827948.1
    12. NR_152531.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
    13. NR_152532.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000691213.2
    14. NR_152533.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000450589.7
    15. NR_152534.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000687022.2
    16. NR_186255.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000452197.6
    17. NR_186256.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827993.1
    18. NR_186257.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827970.1
    19. NR_186258.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
    20. NR_186259.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827972.1
    21. NR_186260.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
    22. NR_186261.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000691982.2
    23. NR_186262.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827958.1
    24. NR_186263.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000828016.1
    25. NR_186264.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000688952.2
    26. NR_186265.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000703059.1
    27. NR_186266.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827989.1
    28. NR_186267.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827992.1
    29. NR_186268.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000690761.2
    30. NR_186269.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000828009.1
    31. NR_186270.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827986.1
    32. NR_186271.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
    33. NR_186272.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827979.1
    34. NR_186273.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
    35. NR_186274.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
    36. NR_186275.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000690228.2
    37. NR_186277.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000828007.1
    38. NR_186278.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000828020.1
    39. NR_186279.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
    40. NR_186280.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827956.1
    41. NR_186281.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000690448.2
    42. NR_186282.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000691137.2
    43. NR_186283.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000690172.2
    44. NR_186284.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000448718.7
    45. NR_186285.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000827981.1
    46. NR_186286.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
      Related
      ENST00000687987.2
    47. NR_186287.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
    48. NR_186288.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
    49. NR_186289.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170
    50. NR_186290.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136170

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      173863901..173869045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      173222019..173227165 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)