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    Prag1 PEAK1 related kinase activating pseudokinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 244418, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Prag1provided by MGI
    Official Full Name
    PEAK1 related kinase activating pseudokinase 1provided by MGI
    Primary source
    MGI:MGI:1196223
    See related
    Ensembl:ENSMUSG00000050271 AllianceGenome:MGI:1196223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NACK; Sgk223; D8Ertd82e; mFLJ00269; 9830148H23
    Summary
    Predicted to enable identical protein binding activity and protein kinase activity. Involved in regulation of Notch signaling pathway. Located in nucleus. Is expressed in forebrain; spinal cord; telencephalon; and vibrissa. Orthologous to human PRAG1 (PEAK1 related, kinase-activating pseudokinase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in small intestine adult (RPKM 9.2), mammary gland adult (RPKM 8.6) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prag1 in Genome Data Viewer
    Location:
    8 A4; 8 22.78 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (36562015..36614939)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (36094827..36147787)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:37091412-37091733 Neighboring gene ribosomal protein S12, pseudogene 24 Neighboring gene predicted gene, 39163 Neighboring gene STARR-positive B cell enhancer ABC_E8845 Neighboring gene STARR-seq mESC enhancer starr_21199 Neighboring gene STARR-positive B cell enhancer ABC_E5001 Neighboring gene predicted gene, 38414 Neighboring gene STARR-seq mESC enhancer starr_21203 Neighboring gene predicted gene, 39164

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis. Weaver KL, et al. Cancer Res, 2014 Sep 1. PMID 25038227, Free PMC Article
    2. Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity. Tanaka H, et al. J Biol Chem, 2006 Apr 14. PMID 16481321
    3. The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Caenepeel S, et al. Proc Natl Acad Sci U S A, 2004 Aug 10. PMID 15289607, Free PMC Article
    4. The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization. Titz B, et al. Oncogene, 2010 Nov 4. PMID 20697350, Free PMC Article
    5. Rescue of neuropsychiatric phenotypes in a mouse model of 16p11.2 duplication syndrome by genetic correction of an epilepsy network hub. Forrest MP, et al. Nat Commun, 2023 Feb 17. PMID 36808153, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Also known as SgK223, a member of the NKF3 family of protein kinases predicted to be catalytically inactive.
      Title: The mouse kinome: discovery and comparative genomics of all mouse protein kinases.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ00269, MGC100334

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inactive tyrosine-protein kinase PRAG1
    Names
    notch activation complex kinase
    pragmin
    sugen kinase 223
    tyrosine-protein kinase PRAG1
    tyrosine-protein kinase SgK223
    NP_001413501.1
    NP_766499.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426572.1 → NP_001413501.1  inactive tyrosine-protein kinase PRAG1

      Status: VALIDATED

      Source sequence(s)
      AC121858
      UniProtKB/Swiss-Prot
      E9QLH9, Q571I4, Q8CB68

    2. NM_172911.4 → NP_766499.2  inactive tyrosine-protein kinase PRAG1

      See identical proteins and their annotated locations for NP_766499.2

      Status: VALIDATED

      Source sequence(s)
      AC121858
      Consensus CDS
      CCDS22247.2
      UniProtKB/Swiss-Prot
      E9QLH9, Q571I4, Q8CB68
      Related
      ENSMUSP00000106118.2, ENSMUST00000110492.2
      Conserved Domains (2) summary
      PHA03247
      Location:387 → 603
      PHA03247; large tegument protein UL36; Provisional
      cl21453
      Location:1094 → 1297
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      36562015..36614939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q571I4.3 GenPept UniProtKB/Swiss-Prot:Q571I4

    Gene LinkOut

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