Ccni cyclin I [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccniprovided by MGI
Official Full Name: cyclin Iprovided by MGI
Primary source: MGI:MGI:1341077
See related: Ensembl:ENSMUSG00000063015 AllianceGenome:MGI:1341077
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in G1/S transition of mitotic cell cycle. Predicted to act upstream of or within regulation of cell cycle. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. Is expressed in cerebellum and retina layer. Orthologous to human CCNI (cyclin I). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 56.6), colon adult (RPKM 53.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E2; 5 47.29 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (93329796..93354348, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (93181933..93206495, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Subcellular localization of Cdk5 is determined by its specific activators, cyclin I and p35.
Title: Cyclin I and p35 determine the subcellular distribution of Cdk5.
Both cyclin I and p35 are required for maximal survival benefit of cyclin-dependent kinase 5 in kidney podocytes.
Title: Both cyclin I and p35 are required for maximal survival benefit of cyclin-dependent kinase 5 in kidney podocytes.
Cyclin I protects podocytes from apoptosis, and we provide preliminary data to suggest that this is mediated by stabilization of p21(Cip1/Waf1).
Title: Cyclin I protects podocytes from apoptosis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224422

RH142357 (e-PCR)
- UniSTS:231604

Ccni (e-PCR), detects polymorphism
- UniSTS:531445

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell cycle	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cyclin-I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001420723.1 → NP_001407652.1 cyclin-I

Status: VALIDATED

Source sequence(s)

AC134827

UniProtKB/Swiss-Prot

G3X985, Q9Z2V9
NM_017367.4 → NP_059063.2 cyclin-I

See identical proteins and their annotated locations for NP_059063.2

Status: VALIDATED

Source sequence(s)

AC134827

Consensus CDS

CCDS19436.1

UniProtKB/Swiss-Prot

G3X985, Q9Z2V9

UniProtKB/TrEMBL

Q8C7E2, Q99LF2

Related

ENSMUSP00000050189.9, ENSMUST00000058550.15

Conserved Domains (1) summary

pfam00134
Location:39 → 142

Cyclin_N; Cyclin, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

93329796..93354348 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254086.2 → XP_030109946.1 cyclin-I isoform X2

UniProtKB/TrEMBL

Q8C7E2

Conserved Domains (1) summary

pfam00134
Location:27 → 130

Cyclin_N; Cyclin, N-terminal domain