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    LOC129662742 ReSE screen-validated silencer GRCh37_chr10:75574449-75574702 [ Homo sapiens (human) ]

    Gene ID: 129662742, updated on 12-Sep-2024

    Summary

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    Gene symbol
    LOC129662742
    Gene description
    ReSE screen-validated silencer GRCh37_chr10:75574449-75574702
    Gene type
    biological region
    Feature type(s)
    regulatory: silencer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in HepG2 liver carcinoma cells. [provided by RefSeq, Apr 2023]
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    Genomic context

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    See LOC129662742 in Genome Data Viewer
    Location:
    chromosome: 10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73814691..73814944)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74686087..74686340)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75574449..75574702)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene NDST2-ZSWIM8-AS1 readthrough Neighboring gene zinc finger SWIM-type containing 8 Neighboring gene ZSWIM8 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2489 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2490 Neighboring gene N-deacetylase and N-sulfotransferase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75579102-75579602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75579603-75580103 Neighboring gene calcium/calmodulin dependent protein kinase II gamma Neighboring gene MPRA-validated peak1013 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:75617818-75618318 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:75618319-75618819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2493 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3579 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3580 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:75646944-75648143 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:75648172-75649130 Neighboring gene uncharacterized LOC124902454 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:75668366-75669565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2495 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:75672789-75673988 Neighboring gene chromosome 10 putative open reading frame 55 Neighboring gene plasminogen activator, urokinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_159750.1 

      Range
      101..354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      73814691..73814944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      74686087..74686340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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