Myo3a myosin IIIA [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Myo3aprovided by RGD
Official Full Name: myosin IIIAprovided by RGD
Primary source: RGD:1560083
See related: EnsemblRapid:ENSRNOG00000018478 AllianceGenome:RGD:1560083
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including ADP binding activity; calmodulin binding activity; and plus-end directed microfilament motor activity. Predicted to be involved in several processes, including inner ear morphogenesis; positive regulation of filopodium assembly; and sensory perception of sound. Predicted to act upstream of or within inner ear development and protein phosphorylation. Predicted to be located in cytoplasm and filopodium. Predicted to be part of filamentous actin. Predicted to be active in filopodium tip; photoreceptor inner segment; and stereocilium tip. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 90 and autosomal recessive nonsyndromic deafness 30. Orthologous to human MYO3A (myosin IIIA). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Lung (RPKM 4.8), Adrenal (RPKM 2.0) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (89451567..89667654)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (84543465..84759562)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (88952635..89167538)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This study provides the basis for understanding the role of myosin IIIa and espin 1 in regulating stereocilia length.
Title: Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables plus-end directed microfilament motor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in auditory receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cochlea morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of filopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament length	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin filament length	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
is_active_in filopodium tip	IBA Inferred from Biological aspect of Ancestor more info
located_in filopodium tip	ISO Inferred from Sequence Orthology more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in photoreceptor inner segment	IBA Inferred from Biological aspect of Ancestor more info
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
is_active_in stereocilium tip	IBA Inferred from Biological aspect of Ancestor more info
is_active_in stereocilium tip	ISO Inferred from Sequence Orthology more info
located_in stereocilium tip	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: myosin-IIIa

NP_001406660.1

EC 2.7.11.1

XP_063132775.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.