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    SELPLG selectin P ligand [ Homo sapiens (human) ]

    Gene ID: 6404, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SELPLGprovided by HGNC
    Official Full Name
    selectin P ligandprovided by HGNC
    Primary source
    HGNC:HGNC:10722
    See related
    Ensembl:ENSG00000110876 MIM:600738; AllianceGenome:HGNC:10722
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLA; CD162; PSGL1; PSGL-1
    Summary
    This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
    Expression
    Broad expression in spleen (RPKM 29.0), lymph node (RPKM 26.4) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SELPLG in Genome Data Viewer
    Location:
    12q24.11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (108621895..108633894, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (108596492..108608490, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (109015671..109027670, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4828 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6967 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6969 Neighboring gene iron-sulfur cluster assembly enzyme Neighboring gene ReSE screen-validated silencer GRCh37_chr12:108976096-108976273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108982554-108983282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:108987423-108988089 Neighboring gene transmembrane protein 119 Neighboring gene Sharpr-MPRA regulatory region 9141 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6971 Neighboring gene uncharacterized LOC105369968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6973 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4830 Neighboring gene microRNA 4496 Neighboring gene coronin 1C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6974 Neighboring gene RNA, U7 small nuclear 169 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment. Azab AK, et al. Blood, 2012 Feb 9. PMID 22096244, Free PMC Article
    2. SELPLG gene polymorphisms in relation to plasma SELPLG levels and coronary artery disease. Tregouet DA, et al. Ann Hum Genet, 2003 Nov. PMID 14641238
    3. Adaptive mutations in the genomes of enterovirus 71 strains following infection of mouse cells expressing human P-selectin glycoprotein ligand-1. Miyamura K, et al. J Gen Virol, 2011 Feb. PMID 20943886, Free PMC Article
    4. The variable number of tandem repeat polymorphism in the P-selectin glycoprotein ligand-1 gene is not associated with coronary heart disease. Bugert P, et al. J Mol Med (Berl), 2003 Aug. PMID 12879153
    5. Tyrosine sulfation of the amino terminus of PSGL-1 is critical for enterovirus 71 infection. Nishimura Y, et al. PLoS Pathog, 2010 Nov 4. PMID 21079683, Free PMC Article

    See all (214) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Correlations of PSGL-1 VNTR polymorphism with the susceptibility to severe HFMD associated with EV-71 and the immune status after infection.
      Title: Correlations of PSGL-1 VNTR polymorphism with the susceptibility to severe HFMD associated with EV-71 and the immune status after infection.
    2. PSGL-1 decorated with sialyl Lewis[a/x] promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement.
      Title: PSGL-1 decorated with sialyl Lewis(a/x) promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement.
    3. PSGL-1 is an evolutionarily conserved antiviral restriction factor.
      Title: PSGL-1 is an evolutionarily conserved antiviral restriction factor.
    4. PSGL-1: a novel immune checkpoint driving T-cell dysfunction in obstructive sleep apnea.
      Title: PSGL-1: a novel immune checkpoint driving T-cell dysfunction in obstructive sleep apnea.
    5. PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages.
      Title: PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages.
    6. The effects of SCARB2 and SELPLG gene polymorphisms on EV71 infection in hand, foot and mouth disease.
      Title: The effects of SCARB2 and SELPLG gene polymorphisms on EV71 infection in hand, foot and mouth disease.
    7. Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation.
      Title: Chemokine binding to PSGL-1 is controlled by O-glycosylation and tyrosine sulfation.
    8. PSGL-1 attenuates early TCR signaling to suppress CD8[+] T cell progenitor differentiation and elicit terminal CD8[+] T cell exhaustion.
      Title: PSGL-1 attenuates early TCR signaling to suppress CD8(+) T cell progenitor differentiation and elicit terminal CD8(+) T cell exhaustion.
    9. Lnc-SELPLG-2:1 enhanced osteosarcoma oncogenesis via hsa-miR-10a-5p and the BTRC cascade.
      Title: Lnc-SELPLG-2:1 enhanced osteosarcoma oncogenesis via hsa-miR-10a-5p and the BTRC cascade.
    10. P-selectin glycoprotein ligand-1 (PSGL-1/CD162) is incorporated into clinical HIV-1 isolates and can mediate virus capture and subsequent transfer to permissive cells.
      Title: P-selectin glycoprotein ligand-1 (PSGL-1/CD162) is incorporated into clinical HIV-1 isolates and can mediate virus capture and subsequent transfer to permissive cells.
    Submit: New GeneRIF Correction See all GeneRIFs (156)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog
    Genome-wide association study of conduct disorder symptomatology.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CD3/CD28-activated primary CD4+ T cells downregulates plasma membrane expression of SELPLG (CD162, PSGL1) PubMed
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SELPLG PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Basic sequences in the cytoplasmic domains of PSGL-1, CD43, and CD44 are required for efficient association with HIV-1 Gag in HeLa cells PubMed
    gag The highly basic region (HBR) of HIV-1 MA promotes Gag association with specific UDMs containing PSGL-1, CD43, and CD59 PubMed
    gag HIV-1 Gag multimers associate with a specific subset of uropod-directed microdomains (UDMs) containing PSGL-1, CD43, and CD44 PubMed
    gag HIV-1 Gag co-localizes with both uropod markers PSGL-1 and CD43 on the plasma membrane PubMed
    Vpu vpu HIV-1 Vpu downregulates the cell surface expression of selectin P ligand (SELPLG, CD162) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to interleukin-6 IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in leukocyte adhesive activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in leukocyte migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in leukocyte tethering or rolling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leukocyte tethering or rolling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in symbiont entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in plasma membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in uropod IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    P-selectin glycoprotein ligand 1
    Names
    cutaneous lymphocyte-associated associated antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206609.2 → NP_001193538.1  P-selectin glycoprotein ligand 1 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC007569, AC008119, AK298742, BC029782, CA427270, DC339004
      Consensus CDS
      CCDS55881.1
      UniProtKB/TrEMBL
      A0A0C4DFY0
      Related
      ENSP00000228463.6, ENST00000228463.7
      Conserved Domains (1) summary
      PRK10811
      Location:136 → 295
      rne; ribonuclease E; Reviewed

    2. NM_003006.4 → NP_002997.2  P-selectin glycoprotein ligand 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_002997.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC008119, AK098315, AK225644
      Consensus CDS
      CCDS31895.2
      UniProtKB/Swiss-Prot
      A8K2Y0, B4DQC3, B7Z5C7, J3KMX6, Q12775, Q14242, Q6GTW7, Q8N7J7
      UniProtKB/TrEMBL
      A0A0C4DFY0
      Related
      ENSP00000447752.1, ENST00000550948.2
      Conserved Domains (1) summary
      PRK10811
      Location:120 → 279
      rne; ribonuclease E; Reviewed

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      108621895..108633894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      108596492..108608490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14242.1 GenPept UniProtKB/Swiss-Prot:Q14242

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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