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    CG6296 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43246, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6296provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039470
    Locus tag
    Dmel_CG6296
    See related
    AllianceGenome:FB:FBgn0039470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    DmelL7; Dmel\CG6296
    Summary
    Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6296 in Genome Data Viewer
    Location:
    97D12-97D13; 3-92 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27003236..27005469, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22828958..22831191, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene TweedleC Neighboring gene RYamide receptor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila. Soulé S, et al. Nat Commun, 2020 Feb 20. PMID 32080190, Free PMC Article
    2. Alternative splicing of NURF301 generates distinct NURF chromatin remodeling complexes with altered modified histone binding specificities. Kwon SY, et al. PLoS Genet, 2009 Jul. PMID 19629165, Free PMC Article
    3. Auxin exposure disrupts feeding behavior and fatty acid metabolism in adult Drosophila. Fleck SA, et al. Elife, 2024 Jan 19. PMID 38240746, Free PMC Article
    4. Molecular landscape of modified histones in Drosophila heterochromatic genes and euchromatin-heterochromatin transition zones. Yasuhara JC, et al. PLoS Genet, 2008 Jan. PMID 18208336, Free PMC Article
    5. Multiple tandem gene duplications in a neutral lipase gene cluster in Drosophila. Horne I, et al. Gene, 2008 Mar 31. PMID 18262735

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6296-PA
    NP_651520.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27003236..27005469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143263.1 → NP_651520.1  uncharacterized protein Dmel_CG6296 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651520.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VB94
      Related
      FBpp0084450, FBtr0085078
      Conserved Domains (1) summary
      cd00707
      Location:71 → 337
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VB94 Q9VB94

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