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    RBMY1J RNA binding motif protein Y-linked family 1 member J [ Homo sapiens (human) ]

    Gene ID: 378951, updated on 27-Nov-2024

    Summary

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    Official Symbol
    RBMY1Jprovided by HGNC
    Official Full Name
    RNA binding motif protein Y-linked family 1 member Jprovided by HGNC
    Primary source
    HGNC:HGNC:23917
    See related
    Ensembl:ENSG00000226941 AllianceGenome:HGNC:23917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. This protein likely functions as a splicing factor during spermatogenesis. Multiple closely related paralogs of this gene are found in a gene cluster in the AZFb azoospermia factor region of chromosome Y. Most of these related copies are thought to be pseudogenes, though several likely encode functional proteins. [provided by RefSeq, Mar 2016]
    Expression
    Restricted expression toward testis (RPKM 5.5) See more
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    Genomic context

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    See RBMY1J in Genome Data Viewer
    Location:
    Yq11.223
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (22403410..22424870)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (22997071..23018537, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (24549557..24564028)

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein Y-linked family 2 member V, pseudogene Neighboring gene testis specific protein Y-linked 21, pseudogene Neighboring gene uncharacterized LOC101929148 Neighboring gene testis expressed transcript, Y-linked 6 Neighboring gene PTPN13 like Y-linked

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RBMY, a male germ cell-specific RNA-binding protein, activated in human liver cancers and transforms rodent fibroblasts. Tsuei DJ, et al. Oncogene, 2004 Jul 29. PMID 15184870
    2. Degeneracy in human multicopy RBM (YRRM), a candidate spermatogenesis gene. Prosser J, et al. Mamm Genome, 1996 Nov. PMID 8875892
    3. A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. Ma K, et al. Cell, 1993 Dec 31. PMID 8269511
    4. Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene. Chai NN, et al. Genomics, 1998 Apr 15. PMID 9598316
    5. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Skaletsky H, et al. Nature, 2003 Jun 19. PMID 12815422

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Clone Names

    • MGC166957, MGC178123

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding motif protein, Y chromosome, family 1 member F/J
    Names
    Y chromosome RNA recognition motif 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006117.4 → NP_001006117.2  RNA-binding motif protein, Y chromosome, family 1 member F/J

      See identical proteins and their annotated locations for NP_001006117.2

      Status: VALIDATED

      Source sequence(s)
      AC007320
      Consensus CDS
      CCDS35484.1
      UniProtKB/Swiss-Prot
      B2R916, Q15415
      UniProtKB/TrEMBL
      B2RUT9
      Related
      ENSP00000250831.5, ENST00000250831.6
      Conserved Domains (4) summary
      COG0724
      Location:1 → 189
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12382
      Location:7 → 85
      RRM_RBMX_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins
      pfam08081
      Location:174 → 218
      RBM1CTR; RBM1CTR (NUC064) family
      cl28271
      Location:158 → 316
      dnaA; chromosomal replication initiation protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

      Range
      22403410..22424870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442739.1 → XP_047298695.1  RNA-binding motif protein, Y chromosome, family 1 member F/J isoform X3

    2. XM_011531500.2 → XP_011529802.1  RNA-binding motif protein, Y chromosome, family 1 member F/J isoform X1

      See identical proteins and their annotated locations for XP_011529802.1

      UniProtKB/TrEMBL
      B7ZMC0, J3KQ82
      Conserved Domains (4) summary
      COG0724
      Location:1 → 189
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      PRK14086
      Location:158 → 316
      dnaA; chromosomal replication initiator protein DnaA
      pfam08081
      Location:174 → 218
      RBM1CTR; RBM1CTR (NUC064) family
      cd12382
      Location:7 → 85
      RRM_RBMX_like; RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein G (hnRNP G), Y chromosome RNA recognition motif 1 (hRBMY), testis-specific heterogeneous nuclear ribonucleoprotein G-T (hnRNP G-T) and similar proteins

    3. XM_011531503.2 → XP_011529805.1  RNA-binding motif protein, Y chromosome, family 1 member F/J isoform X2

      Conserved Domains (1) summary
      pfam08081
      Location:34 → 78
      RBM1CTR; RBM1CTR (NUC064) family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060948.1 Alternate T2T-CHM13v2.0

      Range
      22997071..23018537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328311.1 → XP_054184286.1  RNA-binding motif protein, Y chromosome, family 1 member F/J isoform X7

    2. XM_054328309.1 → XP_054184284.1  RNA-binding motif protein, Y chromosome, family 1 member F/J isoform X5

    3. XM_054328308.1 → XP_054184283.1  RNA-binding motif protein, Y chromosome, family 1 member F/J isoform X4

      UniProtKB/TrEMBL
      J3KQ82

    4. XM_054328310.1 → XP_054184285.1  RNA-binding motif protein, Y chromosome, family 1 member F/J isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15415.2 GenPept UniProtKB/Swiss-Prot:Q15415

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