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    ASB15 ankyrin repeat and SOCS box containing 15 [ Homo sapiens (human) ]

    Gene ID: 142685, updated on 27-Nov-2024

    Summary

    Official Symbol
    ASB15provided by HGNC
    Official Full Name
    ankyrin repeat and SOCS box containing 15provided by HGNC
    Primary source
    HGNC:HGNC:19767
    See related
    Ensembl:ENSG00000146809 MIM:619757; AllianceGenome:HGNC:19767
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the suppressor of cytokine signaling box superfamily. The proteins in this superfamily participate in the ubiquitin-proteasome system for the degradation of proteins in the cell cycle and signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
    Expression
    Biased expression in heart (RPKM 6.0), kidney (RPKM 2.1) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ASB15 in Genome Data Viewer
    Location:
    7q31.32
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (123567008..123639481)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (124883774..124956264)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (123241875..123279535)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 296, pseudogene Neighboring gene IQ motif and ubiquitin domain containing Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:123167408-123168034 Neighboring gene uncharacterized LOC124901740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26567 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:123197145-123198344 Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 Neighboring gene Sharpr-MPRA regulatory region 8884 Neighboring gene ASB15 antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:123269048-123269605 Neighboring gene leiomodin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:123332146-123332646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:123332647-123333147 Neighboring gene WASP like actin nucleation promoting factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18587 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:123388787-123389441

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ43370, DKFZp779M1258

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    ankyrin repeat and SOCS box protein 15
    Names
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034019.2 RefSeqGene

      Range
      39815..77475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001290258.2NP_001277187.1  ankyrin repeat and SOCS box protein 15

      See identical proteins and their annotated locations for NP_001277187.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC006333, AF403033, AK125360, BC100874, CR749595
      Consensus CDS
      CCDS34742.1
      UniProtKB/Swiss-Prot
      Q3ZCP3, Q3ZCP5, Q68D37, Q8WXK1
      UniProtKB/TrEMBL
      A0A384NYV2
      Related
      ENSP00000416433.1, ENST00000451215.6
      Conserved Domains (4) summary
      COG0666
      Location:25205
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:138263
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:178207
      ANK; ANK repeat [structural motif]
      cl02533
      Location:532587
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    2. NM_080928.4NP_563616.3  ankyrin repeat and SOCS box protein 15

      See identical proteins and their annotated locations for NP_563616.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC006333, AF403033, AK125360, BC100874, CR749595
      Consensus CDS
      CCDS34742.1
      UniProtKB/Swiss-Prot
      Q3ZCP3, Q3ZCP5, Q68D37, Q8WXK1
      UniProtKB/TrEMBL
      A0A384NYV2
      Related
      ENSP00000275699.3, ENST00000275699.4
      Conserved Domains (4) summary
      COG0666
      Location:25205
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:138263
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:178207
      ANK; ANK repeat [structural motif]
      cl02533
      Location:532587
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      123567008..123639481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515819.3XP_011514121.1  ankyrin repeat and SOCS box protein 15 isoform X2

      See identical proteins and their annotated locations for XP_011514121.1

      UniProtKB/Swiss-Prot
      Q3ZCP3, Q3ZCP5, Q68D37, Q8WXK1
      UniProtKB/TrEMBL
      A0A384NYV2
      Related
      ENSP00000397655.1, ENST00000451558.5
      Conserved Domains (4) summary
      COG0666
      Location:25205
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:138263
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:178207
      ANK; ANK repeat [structural motif]
      cl02533
      Location:532587
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    2. XM_017011757.2XP_016867246.1  ankyrin repeat and SOCS box protein 15 isoform X2

      UniProtKB/Swiss-Prot
      Q3ZCP3, Q3ZCP5, Q68D37, Q8WXK1
      UniProtKB/TrEMBL
      A0A384NYV2
      Conserved Domains (4) summary
      COG0666
      Location:25205
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:138263
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:178207
      ANK; ANK repeat [structural motif]
      cl02533
      Location:532587
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    3. XM_011515818.3XP_011514120.1  ankyrin repeat and SOCS box protein 15 isoform X2

      See identical proteins and their annotated locations for XP_011514120.1

      UniProtKB/Swiss-Prot
      Q3ZCP3, Q3ZCP5, Q68D37, Q8WXK1
      UniProtKB/TrEMBL
      A0A384NYV2
      Conserved Domains (4) summary
      COG0666
      Location:25205
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:138263
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:178207
      ANK; ANK repeat [structural motif]
      cl02533
      Location:532587
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    4. XM_011515817.3XP_011514119.1  ankyrin repeat and SOCS box protein 15 isoform X2

      See identical proteins and their annotated locations for XP_011514119.1

      UniProtKB/Swiss-Prot
      Q3ZCP3, Q3ZCP5, Q68D37, Q8WXK1
      UniProtKB/TrEMBL
      A0A384NYV2
      Conserved Domains (4) summary
      COG0666
      Location:25205
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:138263
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:178207
      ANK; ANK repeat [structural motif]
      cl02533
      Location:532587
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    5. XM_005250146.5XP_005250203.1  ankyrin repeat and SOCS box protein 15 isoform X2

      See identical proteins and their annotated locations for XP_005250203.1

      UniProtKB/Swiss-Prot
      Q3ZCP3, Q3ZCP5, Q68D37, Q8WXK1
      UniProtKB/TrEMBL
      A0A384NYV2
      Conserved Domains (4) summary
      COG0666
      Location:25205
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:138263
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:178207
      ANK; ANK repeat [structural motif]
      cl02533
      Location:532587
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    6. XM_011515820.3XP_011514122.1  ankyrin repeat and SOCS box protein 15 isoform X2

      See identical proteins and their annotated locations for XP_011514122.1

      UniProtKB/Swiss-Prot
      Q3ZCP3, Q3ZCP5, Q68D37, Q8WXK1
      UniProtKB/TrEMBL
      A0A384NYV2
      Conserved Domains (4) summary
      COG0666
      Location:25205
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:138263
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:178207
      ANK; ANK repeat [structural motif]
      cl02533
      Location:532587
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    7. XM_011515816.3XP_011514118.1  ankyrin repeat and SOCS box protein 15 isoform X1

      Conserved Domains (4) summary
      cd00204
      Location:144269
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:121213
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:184213
      ANK; ANK repeat [structural motif]
      cl02533
      Location:538593
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    8. XM_011515821.3XP_011514123.1  ankyrin repeat and SOCS box protein 15 isoform X3

      Conserved Domains (4) summary
      cd00204
      Location:131249
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:135226
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:131160
      ANK; ANK repeat [structural motif]
      cl02533
      Location:485540
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    9. XM_017011756.3XP_016867245.1  ankyrin repeat and SOCS box protein 15 isoform X2

      UniProtKB/Swiss-Prot
      Q3ZCP3, Q3ZCP5, Q68D37, Q8WXK1
      UniProtKB/TrEMBL
      A0A384NYV2
      Conserved Domains (4) summary
      COG0666
      Location:25205
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:138263
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:178207
      ANK; ANK repeat [structural motif]
      cl02533
      Location:532587
      SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    10. XM_017011758.2XP_016867247.1  ankyrin repeat and SOCS box protein 15 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      124883774..124956264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357296.1XP_054213271.1  ankyrin repeat and SOCS box protein 15 isoform X2

    2. XM_054357298.1XP_054213273.1  ankyrin repeat and SOCS box protein 15 isoform X2

    3. XM_054357294.1XP_054213269.1  ankyrin repeat and SOCS box protein 15 isoform X2

    4. XM_054357292.1XP_054213267.1  ankyrin repeat and SOCS box protein 15 isoform X2

    5. XM_054357293.1XP_054213268.1  ankyrin repeat and SOCS box protein 15 isoform X2

    6. XM_054357295.1XP_054213270.1  ankyrin repeat and SOCS box protein 15 isoform X2

    7. XM_054357291.1XP_054213266.1  ankyrin repeat and SOCS box protein 15 isoform X1

    8. XM_054357299.1XP_054213274.1  ankyrin repeat and SOCS box protein 15 isoform X3

    9. XM_054357297.1XP_054213272.1  ankyrin repeat and SOCS box protein 15 isoform X2

    10. XM_054357300.1XP_054213275.1  ankyrin repeat and SOCS box protein 15 isoform X4