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    DTX2 deltex E3 ubiquitin ligase 2 [ Homo sapiens (human) ]

    Gene ID: 113878, updated on 27-Nov-2024

    Summary

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    Official Symbol
    DTX2provided by HGNC
    Official Full Name
    deltex E3 ubiquitin ligase 2provided by HGNC
    Primary source
    HGNC:HGNC:15973
    See related
    Ensembl:ENSG00000091073 MIM:613141; AllianceGenome:HGNC:15973
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF58
    Summary
    DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
    Expression
    Broad expression in esophagus (RPKM 8.4), testis (RPKM 7.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DTX2 in Genome Data Viewer
    Location:
    7q11.23
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (76461709..76505991)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (77750196..77797419)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (76091026..76135308)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75993799-75994486 Neighboring gene peptidylprolyl isomerase A pseudogene 81 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr7:76008919-76009532 and GRCh37_chr7:76009533-76010146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76018334-76019171 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76019172-76020008 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18315 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26200 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:76035061-76035561 Neighboring gene scavenger receptor cysteine rich family member with 4 domains Neighboring gene zona pellucida glycoprotein 3 Neighboring gene Sharpr-MPRA regulatory region 7220 Neighboring gene Sharpr-MPRA regulatory region 8731 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:76073005-76073916 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:76073917-76074826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76085525-76086398 Neighboring gene farnesyl diphosphate synthase pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76114631-76115532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76115533-76116434 Neighboring gene uncharacterized LOC124901675 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:76138251-76138456 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76139334-76139906 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76139907-76140479 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76141233-76141884 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76141885-76142536 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76142537-76143186 Neighboring gene uroplakin 3B Neighboring gene speedy/RINGO cell cycle regulator family member E16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos. Yi Z, et al. DNA Seq, 2006 Jun. PMID 17286044
    2. [DTX2 overexpression promotes migration and invasion of colorectal cancer cells through the Notch2/Akt axis]. Ma Z, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2023 Mar 20. PMID 37087577, Free PMC Article
    3. DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates. Zhu K, et al. Sci Adv, 2022 Oct 7. PMID 36197986, Free PMC Article
    4. Single-nucleotide polymorphisms in NAGNAG acceptors are highly predictive for variations of alternative splicing. Hiller M, et al. Am J Hum Genet, 2006 Feb. PMID 16400609, Free PMC Article
    5. Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor. Yamamoto N, et al. J Biol Chem, 2001 Nov 30. PMID 11564735

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [DTX2 overexpression promotes migration and invasion of colorectal cancer cells through the Notch2/Akt axis].
      Title: [DTX2 overexpression promotes migration and invasion of colorectal cancer cells through the Notch2/Akt axis].
    2. DTX2 is a gene encoding a WWE-RING-finger protein and involved in regulating heart development and heart functions.
      Title: cDNA cloning, characterization and expression analysis of DTX2, a human WWE and RING-finger gene, in human embryos.
    3. It is reported that BBAP and the human family of DTX proteins (DTX1, DTX2, and DTX3) function as E3 ligases based on their capacity for self-ubiquitination.
      Title: The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1528, MGC71098

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase DTX2
    Names
    RING-type E3 ubiquitin transferase DTX2
    deltex 2, E3 ubiquitin ligase
    deltex homolog 2
    deltex2
    hDTX2
    protein deltex-2
    ring finger protein 58
    zinc ion binding protein
    NP_001096064.1
    NP_001096065.1
    NP_001096066.1
    NP_065943.2
    XP_011514076.1
    XP_016867213.1
    XP_016867215.1
    XP_016867219.1
    XP_024302417.1
    XP_047275808.1
    XP_047275809.1
    XP_047275810.1
    XP_047275811.1
    XP_047275812.1
    XP_047275813.1
    XP_047275814.1
    XP_047275815.1
    XP_047275816.1
    XP_047275817.1
    XP_047275818.1
    XP_054213158.1
    XP_054213159.1
    XP_054213160.1
    XP_054213161.1
    XP_054213162.1
    XP_054213163.1
    XP_054213164.1
    XP_054213165.1
    XP_054213166.1
    XP_054213167.1
    XP_054213168.1
    XP_054213169.1
    XP_054213170.1
    XP_054213171.1
    XP_054213172.1
    XP_054213173.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102594.3 → NP_001096064.1  probable E3 ubiquitin-protein ligase DTX2 isoform a

      See identical proteins and their annotated locations for NP_001096064.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and encodes isoform A. Variants 1-3 encode the same isoform (A).
      Source sequence(s)
      AB040961, AY225124, BC008856, BC018555, DA003606
      Consensus CDS
      CCDS5587.1
      UniProtKB/Swiss-Prot
      Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200
      UniProtKB/TrEMBL
      E7ET89
      Related
      ENSP00000411986.2, ENST00000430490.7
      Conserved Domains (4) summary
      smart00678
      Location:21 → 105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:481 → 613
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd16672
      Location:411 → 482
      RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
      cl26464
      Location:166 → 394
      Atrophin-1; Atrophin-1 family

    2. NM_001102595.3 → NP_001096065.1  probable E3 ubiquitin-protein ligase DTX2 isoform a

      See identical proteins and their annotated locations for NP_001096065.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform A. Variants 1-3 encode the same isoform (A).
      Source sequence(s)
      AY225124, BC008856, BC018555, DA003606
      Consensus CDS
      CCDS5587.1
      UniProtKB/Swiss-Prot
      Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200
      UniProtKB/TrEMBL
      E7ET89
      Related
      ENSP00000390218.2, ENST00000413936.6
      Conserved Domains (4) summary
      smart00678
      Location:21 → 105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:481 → 613
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd16672
      Location:411 → 482
      RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
      cl26464
      Location:166 → 394
      Atrophin-1; Atrophin-1 family

    3. NM_001102596.2 → NP_001096066.1  probable E3 ubiquitin-protein ligase DTX2 isoform b

      See identical proteins and their annotated locations for NP_001096066.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon, compared to variant 1, and encodes a shorter isoform (B), compared to isoform A.
      Source sequence(s)
      AY225125, BC008856, BP306192
      Consensus CDS
      CCDS43605.1
      UniProtKB/TrEMBL
      E7ET89
      Related
      ENSP00000392545.2, ENST00000446820.6
      Conserved Domains (3) summary
      smart00678
      Location:21 → 105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:434 → 566
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd16672
      Location:364 → 435
      RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

    4. NM_020892.4 → NP_065943.2  probable E3 ubiquitin-protein ligase DTX2 isoform a

      See identical proteins and their annotated locations for NP_065943.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (A). Variants 1-3 encode the same isoform (A).
      Source sequence(s)
      AY225124, BC008856, BC018555, DA917716
      Consensus CDS
      CCDS5587.1
      UniProtKB/Swiss-Prot
      Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200
      UniProtKB/TrEMBL
      E7ET89
      Related
      ENSP00000322885.5, ENST00000324432.9
      Conserved Domains (4) summary
      smart00678
      Location:21 → 105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:481 → 613
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd16672
      Location:411 → 482
      RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
      cl26464
      Location:166 → 394
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      76461709..76505991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419856.1 → XP_047275812.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

      UniProtKB/Swiss-Prot
      Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200

    2. XM_047419854.1 → XP_047275810.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

      UniProtKB/Swiss-Prot
      Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200

    3. XM_047419855.1 → XP_047275811.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

      UniProtKB/Swiss-Prot
      Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200

    4. XM_047419853.1 → XP_047275809.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

      UniProtKB/Swiss-Prot
      Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200

    5. XM_047419860.1 → XP_047275816.1  probable E3 ubiquitin-protein ligase DTX2 isoform X3

    6. XM_047419858.1 → XP_047275814.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

    7. XM_047419862.1 → XP_047275818.1  probable E3 ubiquitin-protein ligase DTX2 isoform X4

    8. XM_017011726.3 → XP_016867215.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

      UniProtKB/TrEMBL
      E7ET89
      Conserved Domains (3) summary
      smart00678
      Location:21 → 105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:434 → 566
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd16672
      Location:364 → 435
      RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins

    9. XM_047419857.1 → XP_047275813.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

      UniProtKB/Swiss-Prot
      Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200

    10. XM_047419861.1 → XP_047275817.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

      UniProtKB/Swiss-Prot
      Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200

    11. XM_011515774.2 → XP_011514076.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

      See identical proteins and their annotated locations for XP_011514076.1

      UniProtKB/Swiss-Prot
      Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200
      UniProtKB/TrEMBL
      E7ET89
      Conserved Domains (4) summary
      smart00678
      Location:21 → 105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:481 → 613
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd16672
      Location:411 → 482
      RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
      cl26464
      Location:166 → 394
      Atrophin-1; Atrophin-1 family

    12. XM_047419852.1 → XP_047275808.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

      UniProtKB/Swiss-Prot
      Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200

    13. XM_047419859.1 → XP_047275815.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

    14. XM_024446649.2 → XP_024302417.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

      UniProtKB/Swiss-Prot
      Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200
      UniProtKB/TrEMBL
      E7ET89
      Conserved Domains (4) summary
      smart00678
      Location:21 → 105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:481 → 613
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd16672
      Location:411 → 482
      RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
      cl26464
      Location:166 → 394
      Atrophin-1; Atrophin-1 family

    15. XM_017011730.3 → XP_016867219.1  probable E3 ubiquitin-protein ligase DTX2 isoform X5

    16. XM_017011724.2 → XP_016867213.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

      UniProtKB/Swiss-Prot
      Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200
      UniProtKB/TrEMBL
      E7ET89
      Conserved Domains (4) summary
      smart00678
      Location:21 → 105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:481 → 613
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd16672
      Location:411 → 482
      RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
      cl26464
      Location:166 → 394
      Atrophin-1; Atrophin-1 family

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187561.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1310..5010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      77750196..77797419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357187.1 → XP_054213162.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    2. XM_054357185.1 → XP_054213160.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    3. XM_054357188.1 → XP_054213163.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    4. XM_054357184.1 → XP_054213159.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    5. XM_054357195.1 → XP_054213170.1  probable E3 ubiquitin-protein ligase DTX2 isoform X3

    6. XM_054357192.1 → XP_054213167.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

    7. XM_054357196.1 → XP_054213171.1  probable E3 ubiquitin-protein ligase DTX2 isoform X4

    8. XM_054357193.1 → XP_054213168.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

    9. XM_054357189.1 → XP_054213164.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    10. XM_054357191.1 → XP_054213166.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    11. XM_054357183.1 → XP_054213158.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    12. XM_054357194.1 → XP_054213169.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

    13. XM_054357190.1 → XP_054213165.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    14. XM_054357197.1 → XP_054213172.1  probable E3 ubiquitin-protein ligase DTX2 isoform X6

    15. XM_054357198.1 → XP_054213173.1  probable E3 ubiquitin-protein ligase DTX2 isoform X5

    16. XM_054357186.1 → XP_054213161.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86UW9.3 GenPept UniProtKB/Swiss-Prot:Q86UW9

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