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    ASCC2 activating signal cointegrator 1 complex subunit 2 [ Homo sapiens (human) ]

    Gene ID: 84164, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ASCC2provided by HGNC
    Official Full Name
    activating signal cointegrator 1 complex subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:24103
    See related
    Ensembl:ENSG00000100325 MIM:614216; AllianceGenome:HGNC:24103
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p100; ASC1p100
    Summary
    Enables K63-linked polyubiquitin modification-dependent protein binding activity. Involved in regulation of DNA-templated transcription; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Located in nucleus. Part of DNA repair complex and activating signal cointegrator 1 complex. Is active in cytosolic ribosome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 13.0), testis (RPKM 12.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ASCC2 in Genome Data Viewer
    Location:
    22q12.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (29788611..29838274, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (30251982..30301644, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (30184600..30234263, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30133259-30134112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30143413-30144160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30144161-30144906 Neighboring gene calcium binding protein 7 Neighboring gene zinc finger matrin-type 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:30162231-30162880 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:30162881-30163530 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:30179115-30179288 Neighboring gene ubiquinol-cytochrome c reductase, complex III subunit X Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:30195179-30195679 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:30194678-30195178 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:30196571-30197566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18820 Neighboring gene Sharpr-MPRA regulatory region 3108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18822 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13597 Neighboring gene Sharpr-MPRA regulatory region 2042 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30302705-30303206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30303207-30303706 Neighboring gene RNA, U6 small nuclear 331, pseudogene Neighboring gene myotubularin related protein 3 Neighboring gene RNA, U5F small nuclear 5, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations. Jia J, et al. Nat Commun, 2020 Nov 2. PMID 33139697, Free PMC Article
    2. Cellular response to small molecules that selectively stall protein synthesis by the ribosome. Liaud N, et al. PLoS Genet, 2019 Mar. PMID 30875366, Free PMC Article
    3. Identification of key genes in coronary artery disease: an integrative approach based on weighted gene co-expression network analysis and their correlation with immune infiltration. Yang Y, et al. Aging (Albany NY), 2021 Mar 3. PMID 33686958, Free PMC Article
    4. RNA ligase-like domain in activating signal cointegrator 1 complex subunit 1 (ASCC1) regulates ASCC complex function during alkylation damage. Soll JM, et al. J Biol Chem, 2018 Aug 31. PMID 29997253, Free PMC Article
    5. The ASC-1 Complex Disassembles Collided Ribosomes. Juszkiewicz S, et al. Mol Cell, 2020 Aug 20. PMID 32579943, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of key genes in coronary artery disease: an integrative approach based on weighted gene co-expression network analysis and their correlation with immune infiltration.
      Title: Identification of key genes in coronary artery disease: an integrative approach based on weighted gene co-expression network analysis and their correlation with immune infiltration.
    2. The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations.
      Title: The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA alkylation repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in DNA duplex unwinding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rescue of stalled ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rescue of stalled ribosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosome disassembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA repair complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of activating signal cointegrator 1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    activating signal cointegrator 1 complex subunit 2
    Names
    ASC-1 complex subunit P100
    trip4 complex subunit p100

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242906.2 → NP_001229835.1  activating signal cointegrator 1 complex subunit 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Consensus CDS
      CCDS56226.1
      UniProtKB/Swiss-Prot
      Q9H1I8
      Related
      ENSP00000437570.1, ENST00000542393.5
      Conserved Domains (1) summary
      cd14364
      Location:393 → 432
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    2. NM_001369920.1 → NP_001356849.1  activating signal cointegrator 1 complex subunit 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Conserved Domains (1) summary
      cd14364
      Location:469 → 508
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    3. NM_001369921.1 → NP_001356850.1  activating signal cointegrator 1 complex subunit 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Consensus CDS
      CCDS13869.1
      UniProtKB/Swiss-Prot
      B7Z8E0, F5H6J9, Q4TT54, Q8TAZ0, Q9H1I8, Q9H711, Q9H9D6
      Conserved Domains (1) summary
      cd14364
      Location:469 → 508
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    4. NM_001369922.1 → NP_001356851.1  activating signal cointegrator 1 complex subunit 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Consensus CDS
      CCDS13869.1
      UniProtKB/Swiss-Prot
      B7Z8E0, F5H6J9, Q4TT54, Q8TAZ0, Q9H1I8, Q9H711, Q9H9D6
      Conserved Domains (1) summary
      cd14364
      Location:469 → 508
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    5. NM_001369923.1 → NP_001356852.1  activating signal cointegrator 1 complex subunit 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Consensus CDS
      CCDS13869.1
      UniProtKB/Swiss-Prot
      B7Z8E0, F5H6J9, Q4TT54, Q8TAZ0, Q9H1I8, Q9H711, Q9H9D6
      Related
      ENSP00000380877.2, ENST00000397771.6
      Conserved Domains (1) summary
      cd14364
      Location:469 → 508
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    6. NM_001369924.1 → NP_001356853.1  activating signal cointegrator 1 complex subunit 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Conserved Domains (1) summary
      cd14364
      Location:469 → 508
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    7. NM_001369925.1 → NP_001356854.1  activating signal cointegrator 1 complex subunit 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Conserved Domains (1) summary
      cd14364
      Location:416 → 455
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    8. NM_001369926.1 → NP_001356855.1  activating signal cointegrator 1 complex subunit 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Conserved Domains (1) summary
      cd14364
      Location:416 → 455
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    9. NM_001369927.1 → NP_001356856.1  activating signal cointegrator 1 complex subunit 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Conserved Domains (1) summary
      cd14364
      Location:416 → 455
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    10. NM_001369928.1 → NP_001356857.1  activating signal cointegrator 1 complex subunit 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Conserved Domains (1) summary
      cd14364
      Location:416 → 455
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    11. NM_001369929.1 → NP_001356858.1  activating signal cointegrator 1 complex subunit 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Conserved Domains (1) summary
      cd14364
      Location:416 → 455
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    12. NM_001369930.1 → NP_001356859.1  activating signal cointegrator 1 complex subunit 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Conserved Domains (1) summary
      cd14364
      Location:391 → 430
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    13. NM_001369931.1 → NP_001356860.1  activating signal cointegrator 1 complex subunit 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Conserved Domains (1) summary
      cd14364
      Location:355 → 394
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    14. NM_001369932.1 → NP_001356861.1  activating signal cointegrator 1 complex subunit 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Conserved Domains (1) summary
      cd14364
      Location:355 → 394
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    15. NM_001369933.1 → NP_001356862.1  activating signal cointegrator 1 complex subunit 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Conserved Domains (1) summary
      cd14364
      Location:355 → 394
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    16. NM_001369934.1 → NP_001356863.1  activating signal cointegrator 1 complex subunit 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Conserved Domains (1) summary
      cd14364
      Location:355 → 394
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    17. NM_001369935.1 → NP_001356864.1  activating signal cointegrator 1 complex subunit 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Conserved Domains (1) summary
      cd14364
      Location:355 → 394
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    18. NM_001369936.1 → NP_001356865.1  activating signal cointegrator 1 complex subunit 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Conserved Domains (1) summary
      cd14364
      Location:355 → 394
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    19. NM_001369937.1 → NP_001356866.1  activating signal cointegrator 1 complex subunit 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Conserved Domains (1) summary
      cd14364
      Location:355 → 394
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    20. NM_001369938.1 → NP_001356867.1  activating signal cointegrator 1 complex subunit 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Conserved Domains (1) summary
      cd14364
      Location:355 → 394
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    21. NM_001369939.1 → NP_001356868.1  activating signal cointegrator 1 complex subunit 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Conserved Domains (1) summary
      cd14364
      Location:355 → 394
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    22. NM_001369940.1 → NP_001356869.1  activating signal cointegrator 1 complex subunit 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Conserved Domains (1) summary
      cd14364
      Location:355 → 394
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    23. NM_001369941.1 → NP_001356870.1  activating signal cointegrator 1 complex subunit 2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      Conserved Domains (1) summary
      cd14364
      Location:355 → 394
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    24. NM_001369942.1 → NP_001356871.1  activating signal cointegrator 1 complex subunit 2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      UniProtKB/TrEMBL
      Q53G98
      Conserved Domains (1) summary
      cd14364
      Location:291 → 330
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    25. NM_001369943.1 → NP_001356872.1  activating signal cointegrator 1 complex subunit 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      UniProtKB/TrEMBL
      Q53G98
      Conserved Domains (1) summary
      cd14364
      Location:233 → 272
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    26. NM_001369944.1 → NP_001356873.1  activating signal cointegrator 1 complex subunit 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      UniProtKB/TrEMBL
      Q53G98
      Conserved Domains (1) summary
      cd14364
      Location:233 → 272
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    27. NM_001369945.1 → NP_001356874.1  activating signal cointegrator 1 complex subunit 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      UniProtKB/TrEMBL
      Q53G98
      Conserved Domains (1) summary
      cd14364
      Location:233 → 272
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    28. NM_001369946.1 → NP_001356875.1  activating signal cointegrator 1 complex subunit 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      UniProtKB/TrEMBL
      Q53G98
      Conserved Domains (1) summary
      cd14364
      Location:233 → 272
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    29. NM_001369947.1 → NP_001356876.1  activating signal cointegrator 1 complex subunit 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      UniProtKB/TrEMBL
      Q53G98
      Conserved Domains (1) summary
      cd14364
      Location:233 → 272
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    30. NM_001369948.1 → NP_001356877.1  activating signal cointegrator 1 complex subunit 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      UniProtKB/TrEMBL
      Q53G98
      Conserved Domains (1) summary
      cd14364
      Location:233 → 272
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    31. NM_001369949.1 → NP_001356878.1  activating signal cointegrator 1 complex subunit 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      UniProtKB/TrEMBL
      Q53G98
      Conserved Domains (1) summary
      cd14364
      Location:233 → 272
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    32. NM_001369950.1 → NP_001356879.1  activating signal cointegrator 1 complex subunit 2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC004882, Z82171
      UniProtKB/TrEMBL
      Q53G98
      Conserved Domains (1) summary
      cd14364
      Location:233 → 272
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    33. NM_032204.5 → NP_115580.2  activating signal cointegrator 1 complex subunit 2 isoform 1

      See identical proteins and their annotated locations for NP_115580.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC025368, BP201867
      Consensus CDS
      CCDS13869.1
      UniProtKB/Swiss-Prot
      B7Z8E0, F5H6J9, Q4TT54, Q8TAZ0, Q9H1I8, Q9H711, Q9H9D6
      Related
      ENSP00000305502.3, ENST00000307790.8
      Conserved Domains (1) summary
      cd14364
      Location:469 → 508
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      29788611..29838274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441548.1 → XP_047297504.1  activating signal cointegrator 1 complex subunit 2 isoform X15

    2. XM_011530455.3 → XP_011528757.1  activating signal cointegrator 1 complex subunit 2 isoform X14

      See identical proteins and their annotated locations for XP_011528757.1

      Conserved Domains (1) summary
      cd14364
      Location:355 → 394
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    3. XM_047441545.1 → XP_047297501.1  activating signal cointegrator 1 complex subunit 2 isoform X11

    4. XM_047441541.1 → XP_047297497.1  activating signal cointegrator 1 complex subunit 2 isoform X9

    5. XM_011530454.3 → XP_011528756.1  activating signal cointegrator 1 complex subunit 2 isoform X14

      See identical proteins and their annotated locations for XP_011528756.1

      Conserved Domains (1) summary
      cd14364
      Location:355 → 394
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    6. XM_011530453.3 → XP_011528755.1  activating signal cointegrator 1 complex subunit 2 isoform X14

      See identical proteins and their annotated locations for XP_011528755.1

      Conserved Domains (1) summary
      cd14364
      Location:355 → 394
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    7. XM_011530448.3 → XP_011528750.1  activating signal cointegrator 1 complex subunit 2 isoform X12

      See identical proteins and their annotated locations for XP_011528750.1

      Conserved Domains (1) summary
      cd14364
      Location:416 → 455
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    8. XM_047441543.1 → XP_047297499.1  activating signal cointegrator 1 complex subunit 2 isoform X11

    9. XM_011530442.4 → XP_011528744.1  activating signal cointegrator 1 complex subunit 2 isoform X6

      See identical proteins and their annotated locations for XP_011528744.1

      Conserved Domains (1) summary
      cd14364
      Location:469 → 508
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    10. XM_047441544.1 → XP_047297500.1  activating signal cointegrator 1 complex subunit 2 isoform X11

    11. XM_011530443.3 → XP_011528745.1  activating signal cointegrator 1 complex subunit 2 isoform X6

      See identical proteins and their annotated locations for XP_011528745.1

      Conserved Domains (1) summary
      cd14364
      Location:469 → 508
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    12. XM_047441547.1 → XP_047297503.1  activating signal cointegrator 1 complex subunit 2 isoform X13

    13. XM_047441546.1 → XP_047297502.1  activating signal cointegrator 1 complex subunit 2 isoform X11

    14. XM_011530445.3 → XP_011528747.1  activating signal cointegrator 1 complex subunit 2 isoform X6

      See identical proteins and their annotated locations for XP_011528747.1

      Conserved Domains (1) summary
      cd14364
      Location:469 → 508
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    15. XM_047441540.1 → XP_047297496.1  activating signal cointegrator 1 complex subunit 2 isoform X8

      UniProtKB/Swiss-Prot
      B7Z8E0, F5H6J9, Q4TT54, Q8TAZ0, Q9H1I8, Q9H711, Q9H9D6

    16. XM_011530444.3 → XP_011528746.1  activating signal cointegrator 1 complex subunit 2 isoform X6

      See identical proteins and their annotated locations for XP_011528746.1

      Conserved Domains (1) summary
      cd14364
      Location:469 → 508
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    17. XM_047441539.1 → XP_047297495.1  activating signal cointegrator 1 complex subunit 2 isoform X6

    18. XM_047441542.1 → XP_047297498.1  activating signal cointegrator 1 complex subunit 2 isoform X10

    19. XM_024452290.2 → XP_024308058.1  activating signal cointegrator 1 complex subunit 2 isoform X5

      Conserved Domains (1) summary
      cd14364
      Location:470 → 509
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    20. XM_024452288.2 → XP_024308056.1  activating signal cointegrator 1 complex subunit 2 isoform X3

      Conserved Domains (1) summary
      cd14364
      Location:498 → 537
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    21. XM_024452287.2 → XP_024308055.1  activating signal cointegrator 1 complex subunit 2 isoform X1

      Conserved Domains (1) summary
      cd14364
      Location:523 → 562
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    22. XM_024452291.2 → XP_024308059.1  activating signal cointegrator 1 complex subunit 2 isoform X7

      Conserved Domains (1) summary
      cd14364
      Location:470 → 509
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    23. XM_024452289.2 → XP_024308057.1  activating signal cointegrator 1 complex subunit 2 isoform X4

      Conserved Domains (1) summary
      cd14364
      Location:498 → 537
      CUE_ASCC2; CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins

    24. XM_047441538.1 → XP_047297494.1  activating signal cointegrator 1 complex subunit 2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      30251982..30301644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054326031.1 → XP_054182006.1  activating signal cointegrator 1 complex subunit 2 isoform X15

    2. XM_054326027.1 → XP_054182002.1  activating signal cointegrator 1 complex subunit 2 isoform X14

    3. XM_054326023.1 → XP_054181998.1  activating signal cointegrator 1 complex subunit 2 isoform X11

    4. XM_054326019.1 → XP_054181994.1  activating signal cointegrator 1 complex subunit 2 isoform X9

    5. XM_054326030.1 → XP_054182005.1  activating signal cointegrator 1 complex subunit 2 isoform X14

    6. XM_054326029.1 → XP_054182004.1  activating signal cointegrator 1 complex subunit 2 isoform X14

    7. XM_054326025.1 → XP_054182000.1  activating signal cointegrator 1 complex subunit 2 isoform X12

    8. XM_054326021.1 → XP_054181996.1  activating signal cointegrator 1 complex subunit 2 isoform X11

    9. XM_054326012.1 → XP_054181987.1  activating signal cointegrator 1 complex subunit 2 isoform X6

    10. XM_054326022.1 → XP_054181997.1  activating signal cointegrator 1 complex subunit 2 isoform X11

    11. XM_054326013.1 → XP_054181988.1  activating signal cointegrator 1 complex subunit 2 isoform X6

    12. XM_054326026.1 → XP_054182001.1  activating signal cointegrator 1 complex subunit 2 isoform X13

    13. XM_054326024.1 → XP_054181999.1  activating signal cointegrator 1 complex subunit 2 isoform X11

    14. XM_054326014.1 → XP_054181989.1  activating signal cointegrator 1 complex subunit 2 isoform X6

    15. XM_054326018.1 → XP_054181993.1  activating signal cointegrator 1 complex subunit 2 isoform X8

      UniProtKB/Swiss-Prot
      B7Z8E0, F5H6J9, Q4TT54, Q8TAZ0, Q9H1I8, Q9H711, Q9H9D6

    16. XM_054326015.1 → XP_054181990.1  activating signal cointegrator 1 complex subunit 2 isoform X6

    17. XM_054326016.1 → XP_054181991.1  activating signal cointegrator 1 complex subunit 2 isoform X6

    18. XM_054326020.1 → XP_054181995.1  activating signal cointegrator 1 complex subunit 2 isoform X10

    19. XM_054326011.1 → XP_054181986.1  activating signal cointegrator 1 complex subunit 2 isoform X5

    20. XM_054326009.1 → XP_054181984.1  activating signal cointegrator 1 complex subunit 2 isoform X3

    21. XM_054326007.1 → XP_054181982.1  activating signal cointegrator 1 complex subunit 2 isoform X1

    22. XM_054326017.1 → XP_054181992.1  activating signal cointegrator 1 complex subunit 2 isoform X7

    23. XM_054326010.1 → XP_054181985.1  activating signal cointegrator 1 complex subunit 2 isoform X4

    24. XM_054326008.1 → XP_054181983.1  activating signal cointegrator 1 complex subunit 2 isoform X2

    25. XM_054326028.1 → XP_054182003.1  activating signal cointegrator 1 complex subunit 2 isoform X14

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H1I8.3 GenPept UniProtKB/Swiss-Prot:Q9H1I8

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