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    PDE9A phosphodiesterase 9A [ Homo sapiens (human) ]

    Gene ID: 5152, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PDE9Aprovided by HGNC
    Official Full Name
    phosphodiesterase 9Aprovided by HGNC
    Primary source
    HGNC:HGNC:8795
    See related
    Ensembl:ENSG00000160191 MIM:602973; AllianceGenome:HGNC:8795
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSPDE9A2
    Summary
    The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in colon (RPKM 12.5), prostate (RPKM 9.8) and 17 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PDE9A in Genome Data Viewer
    Location:
    21q22.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (42653621..42775509)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (41042071..41163988)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (44073731..44195619)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene solute carrier family 37 member 1 Neighboring gene uncharacterized LOC101928212 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13349 Neighboring gene VISTA enhancer hs2248 Neighboring gene MPRA-validated peak4415 silencer Neighboring gene long intergenic non-protein coding RNA 1671 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44037913-44038824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44057507-44058403 Neighboring gene uncharacterized LOC101928255 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44072695-44073416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18529 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44081521-44082390 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44086147-44086653 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44088149-44089095 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44089096-44090041 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44122945-44123824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44126986-44127486 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr21:44144061-44145260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44158941-44159941 Neighboring gene PDE9A antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44176879-44177378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44181049-44181582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44181583-44182114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44187499-44187998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44191023-44191524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44195549-44196050 Neighboring gene uncharacterized LOC107985504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44197711-44198660 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44199612-44200561 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44201049-44201772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44202497-44203220 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44203221-44203942 Neighboring gene long intergenic non-protein coding RNA 1668 Neighboring gene NANOG hESC enhancer GRCh37_chr21:44220991-44221572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44254625-44255576 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18531 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44268253-44268818 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44268819-44269384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44280271-44280829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:44285917-44286612 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44297711-44298674 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:44298675-44299639 Neighboring gene uncharacterized LOC105372817 Neighboring gene WD repeat domain 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer. Susmi TF, et al. BMC Cancer, 2021 May 20. PMID 34016083, Free PMC Article
    2. Identification and distribution of different mRNA variants produced by differential splicing in the human phosphodiesterase 9A gene. Rentero C, et al. Biochem Biophys Res Commun, 2003 Feb 14. PMID 12565835
    3. Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5). Differential tissue distribution and subcellular localization of PDE9A variants. Wang P, et al. Gene, 2003 Sep 18. PMID 14527714
    4. Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding. Huai Q, et al. Proc Natl Acad Sci U S A, 2004 Jun 29. PMID 15210993, Free PMC Article
    5. Specific use of start codons and cellular localization of splice variants of human phosphodiesterase 9A gene. Rentero C, et al. BMC Mol Biol, 2006 Nov 8. PMID 17090334, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer.
      Title: Prognostic and clinicopathological insights of phosphodiesterase 9A gene as novel biomarker in human colorectal cancer.
    2. Evaluation of phosphodiesterase 9A as a novel biomarker in heart failure with preserved ejection fraction.
      Title: Evaluation of phosphodiesterase 9A as a novel biomarker in heart failure with preserved ejection fraction.
    3. PDE9A can regulate cGMP signalling independent of the nitric oxide pathway, and its role in stress-induced heart disease suggests potential as a therapeutic target.
      Title: Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease.
    4. it is concluded that assessment of PDE5 and PDE9 expression may be useful in the differential diagnosis of benign and malignant breast disease and successful treatment of breast cancer
      Title: Evaluation of PDE5 and PDE9 expression in benign and malignant breast tumors.
    5. In vivo effects of PDE9A inhibition included reversal of the respective disruptions of working memory.
      Title: Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo.
    6. PDE9 is widely distributed in the urothelial epithelium of the human lower urinary tract and its potential roles may be different from those of PDE5.
      Title: Phosphodiesterase type 9 (PDE9) in the human lower urinary tract: an immunohistochemical study.
    7. Data show that PDE9A inhibitor, BAY-73-6691, significantly reduced basal and sickle cell (SCA) neutrophil adhesion; this was accompanied by decreased SCA neutrophil surface expressions of the L-selectin and CD11b adhesion molecules.
      Title: Inhibition of phosphodiesterase 9A reduces cytokine-stimulated in vitro adhesion of neutrophils from sickle cell anemia individuals.
    8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Poor replication of candidate genes for major depressive disorder using genome-wide association data.
    10. PDE9A, is unlikely to play an important role in antidepressant outcome in this sample
      Title: Association study of phosphodiesterase genes in the Sequenced Treatment Alternatives to Relieve Depression sample.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of lung function decline in adults with and without asthma.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif downregulates the expression of phosphodiesterase 9A (PDE9A) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ90181

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cGMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cGMP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of neural precursor cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cardiac muscle hypertrophy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
    Names
    CGMP-specific 3',5'-cyclic phosphodiesterase type 9
    phosphodiesterase PDE9A21
    NP_001001567.1
    NP_001001568.1
    NP_001001569.1
    NP_001001570.1
    NP_001001571.1
    NP_001001572.1
    NP_001001573.1
    NP_001001574.1
    NP_001001575.1
    NP_001001576.1
    NP_001001577.1
    NP_001001578.1
    NP_001001579.1
    NP_001001580.1
    NP_001001581.1
    NP_001001582.1
    NP_001001583.1
    NP_001001584.1
    NP_001001585.1
    NP_001302462.1
    NP_002597.1
    XP_011527900.1
    XP_011527902.1
    XP_016883855.1
    XP_054180516.1
    XP_054180517.1
    XP_054180518.1
    XP_054180519.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047067.1 RefSeqGene

      Range
      4870..126758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001001567.2 → NP_001001567.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform b

      See identical proteins and their annotated locations for NP_001001567.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but lacks an internal segment compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AF067224, AI492065, AP001626, BC009047
      Consensus CDS
      CCDS33568.1
      UniProtKB/TrEMBL
      A0A0S2Z4A3
      Related
      ENSP00000335242.4, ENST00000335512.8
      Conserved Domains (1) summary
      pfam00233
      Location:251 → 479
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. NM_001001568.2 → NP_001001568.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform c

      See identical proteins and their annotated locations for NP_001001568.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks three alternate exons compared to variant 1. The resulting predicted isoform (c) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AF067225, AI492065, AP001626, AY196305, BC009047
      Consensus CDS
      CCDS42946.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000381280.3, ENST00000398224.3
      Conserved Domains (1) summary
      pfam00233
      Location:184 → 412
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. NM_001001569.2 → NP_001001569.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform d

      See identical proteins and their annotated locations for NP_001001569.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks four alternate exons compared to variant 1. The resulting predicted isoform (d) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AF067226, AI492065, AP001626, AY196305, BC009047
      Consensus CDS
      CCDS33571.1
      UniProtKB/TrEMBL
      A0A0S2Z475
      Related
      ENSP00000344730.3, ENST00000349112.7
      Conserved Domains (1) summary
      pfam00233
      Location:183 → 411
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    4. NM_001001570.2 → NP_001001570.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform e

      See identical proteins and their annotated locations for NP_001001570.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate exon and lacks two others compared to variant 1. The resulting isoform (e) has the same N- and C-termini but differs in an internal segment compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AI492065, AP001626, AY196299, BC009047
      Consensus CDS
      CCDS33567.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000369685.2, ENST00000380328.6
      Conserved Domains (1) summary
      pfam00233
      Location:258 → 486
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    5. NM_001001571.2 → NP_001001571.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform f

      See identical proteins and their annotated locations for NP_001001571.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two alternate exons compared to variant 1. The resulting predicted isoform (f) is shorter, has a distinct N-terminus, and lacks an internal segment compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AI492065, AP001626, AY196300, BC009047
      Consensus CDS
      CCDS42943.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000381289.3, ENST00000398234.7
      Conserved Domains (1) summary
      pfam00233
      Location:210 → 438
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    6. NM_001001572.2 → NP_001001572.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g

      See identical proteins and their annotated locations for NP_001001572.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks four alternate exons compared to variant 1. The resulting predicted isoform (g) has a shorter N-terminus compared to isoform a. Variants 7, 8, 14, 19, and 20 all encode isoform g.
      Source sequence(s)
      AF048837, AF067223, AI492065, AP001626, AY196301, BC009047
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENST00000467403.5
      Conserved Domains (1) summary
      pfam00233
      Location:104 → 332
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    7. NM_001001573.2 → NP_001001573.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g

      See identical proteins and their annotated locations for NP_001001573.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks three alternate exons compared to variant 1. The resulting predicted isoform (g) has a shorter N-terminus compared to isoform a. Variants 7, 8, 14, 19, and 20 all encode isoform g.
      Source sequence(s)
      AF048837, AF067223, AI492065, AP001626, AY196302, BC009047
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENST00000490803.5
      Conserved Domains (1) summary
      pfam00233
      Location:104 → 332
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    8. NM_001001574.2 → NP_001001574.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform h

      See identical proteins and their annotated locations for NP_001001574.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (h) has the same N- and C-termini but lacks two internal segments compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AI492065, AP001626, AY196303, BC009047
      Consensus CDS
      CCDS42941.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000381291.3, ENST00000398236.7
      Conserved Domains (1) summary
      pfam00233
      Location:225 → 453
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    9. NM_001001575.2 → NP_001001575.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform i

      See identical proteins and their annotated locations for NP_001001575.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks five alternate exons compared to variant 1. The resulting predicted isoform (i) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AI492065, AP001626, AY196304, BC009047
      Consensus CDS
      CCDS42947.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000381283.3, ENST00000398227.7
      Conserved Domains (1) summary
      pfam00233
      Location:151 → 379
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    10. NM_001001576.2 → NP_001001576.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform j

      See identical proteins and their annotated locations for NP_001001576.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) lacks five alternate exons compared to variant 1. The resulting predicted isoform (j) is shorter and has a distinct N-terminus compared to isoform a. Variants 11 and 15 both encode isoform j.
      Source sequence(s)
      AF048837, AF067223, AI492065, AP001626, AY196305, BC009047
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENST00000495521.5
      Conserved Domains (1) summary
      pfam00233
      Location:94 → 322
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    11. NM_001001577.2 → NP_001001577.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform k

      See identical proteins and their annotated locations for NP_001001577.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) lacks four alternate exons compared to variant 1. The resulting predicted isoform (k) is shorter, has a distinct N-terminus, and lacks an internal segment compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AI492065, AP001626, AY196306, BC009047
      Consensus CDS
      CCDS42944.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000381285.3, ENST00000398229.7
      Conserved Domains (1) summary
      pfam00233
      Location:177 → 405
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    12. NM_001001578.2 → NP_001001578.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform l

      See identical proteins and their annotated locations for NP_001001578.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) lacks three alternate exons compared to variant 1. The resulting isoform (l) has the same N- and C-termini but lacks two internal segments compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AI492065, AP001626, AY196307, BC009047
      Consensus CDS
      CCDS33570.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000335365.6, ENST00000335440.10
      Conserved Domains (1) summary
      pfam00233
      Location:209 → 437
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    13. NM_001001579.2 → NP_001001579.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g

      See identical proteins and their annotated locations for NP_001001579.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) lacks three alternate exons compared to variant 1. The resulting predicted isoform (g) has a shorter N-terminus compared to isoform a. Variants 7, 8, 14, 19, and 20 all encode isoform g.
      Source sequence(s)
      AF048837, AF067223, AI492065, AP001626, AY196308, BC009047
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENST00000468805.5
      Conserved Domains (1) summary
      pfam00233
      Location:104 → 332
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    14. NM_001001580.2 → NP_001001580.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform j

      See identical proteins and their annotated locations for NP_001001580.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) lacks six alternate exons compared to variant 1. The resulting predicted isoform (j) is shorter and has a distinct N-terminus compared to isoform a. Variants 11 and 15 both encode isoform j.
      Source sequence(s)
      AF048837, AF067223, AI492065, AP001626, AY196309, BC009047
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENST00000460989.5
      Conserved Domains (1) summary
      pfam00233
      Location:94 → 322
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    15. NM_001001581.2 → NP_001001581.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform m

      See identical proteins and their annotated locations for NP_001001581.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) lacks two alternate exons compared to variant 1. The resulting predicted isoform (m) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AI492065, AP001626, AY196310, BC009047
      Consensus CDS
      CCDS42945.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000381287.3, ENST00000398232.7
      Conserved Domains (1) summary
      pfam00233
      Location:244 → 472
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    16. NM_001001582.2 → NP_001001582.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform n

      See identical proteins and their annotated locations for NP_001001582.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) lacks an alternate exon compared to variant 1. The resulting predicted isoform (n) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AI492065, AP001626, AY196311, BC009047
      Consensus CDS
      CCDS42942.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000381281.3, ENST00000398225.7
      Conserved Domains (1) summary
      pfam00233
      Location:270 → 498
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    17. NM_001001583.2 → NP_001001583.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform o

      See identical proteins and their annotated locations for NP_001001583.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (o) has the same N- and C-termini but lacks an internal segment compared to isoform a.
      Source sequence(s)
      AF048837, AF067223, AI492065, AP001626, AY196312, BC009047
      Consensus CDS
      CCDS33569.1
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENSP00000328699.6, ENST00000328862.10
      Conserved Domains (1) summary
      pfam00233
      Location:285 → 513
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    18. NM_001001584.3 → NP_001001584.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g

      See identical proteins and their annotated locations for NP_001001584.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19) contains an alternate exon and lacks three others compared to variant 1. The resulting predicted isoform (g) has a shorter N-terminus compared to isoform a. Variants 7, 8, 14, 19, and 20 all encode isoform g.
      Source sequence(s)
      AF048837, AF067223, AI492065, AP001626, AP001627, AY196313, BC009047
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENST00000462571.5
      Conserved Domains (1) summary
      pfam00233
      Location:104 → 332
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    19. NM_001001585.2 → NP_001001585.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g

      See identical proteins and their annotated locations for NP_001001585.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20) lacks two alternate exons compared to variant 1. The resulting predicted isoform (g) has a shorter N-terminus compared to isoform a. Variants 7, 8, 14, 19, and 20 all encode isoform g.
      Source sequence(s)
      AF048837, AF067223, AI492065, AP001626, AY196314, BC009047
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENST00000497805.5
      Conserved Domains (1) summary
      pfam00233
      Location:104 → 332
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    20. NM_001315533.2 → NP_001302462.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform p

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (p) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AI492065, AP001626, AP001628, AY701187
      UniProtKB/Swiss-Prot
      O76083
      Related
      ENST00000470987.5
      Conserved Domains (1) summary
      pfam00233
      Location:203 → 431
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    21. NM_002606.3 → NP_002597.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform a

      See identical proteins and their annotated locations for NP_002597.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AF048837, AF067223, AI492065, AP001626, BC009047
      Consensus CDS
      CCDS13690.1
      UniProtKB/Swiss-Prot
      B2RBI5, B4DFI5, D3DSJ8, D3DSJ9, O75490, O75491, O76083, O95225, Q53Y40, Q5QD39, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0
      UniProtKB/TrEMBL
      A0A0S2Z4T6
      Related
      ENSP00000291539.6, ENST00000291539.11
      Conserved Domains (1) summary
      pfam00233
      Location:311 → 539
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      42653621..42775509
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017028366.2 → XP_016883855.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X3

      UniProtKB/Swiss-Prot
      O76083
      Conserved Domains (1) summary
      pfam00233
      Location:104 → 332
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. XM_011529600.3 → XP_011527902.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2

      Conserved Domains (1) summary
      pfam00233
      Location:311 → 452
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. XM_011529598.3 → XP_011527900.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

      Conserved Domains (1) summary
      pfam00233
      Location:263 → 491
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      41042071..41163988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324544.1 → XP_054180519.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X3

    2. XM_054324543.1 → XP_054180518.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2

    3. XM_054324542.1 → XP_054180517.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1

    4. XM_054324541.1 → XP_054180516.1  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76083.1 GenPept UniProtKB/Swiss-Prot:O76083

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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