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    CHD3 chromodomain helicase DNA binding protein 3 [ Homo sapiens (human) ]

    Gene ID: 1107, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CHD3provided by HGNC
    Official Full Name
    chromodomain helicase DNA binding protein 3provided by HGNC
    Primary source
    HGNC:HGNC:1918
    See related
    Ensembl:ENSG00000170004 MIM:602120; AllianceGenome:HGNC:1918
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZFH; Mi-2a; SNIBCPS; Mi2-ALPHA
    Summary
    This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in prostate (RPKM 26.5), brain (RPKM 24.4) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CHD3 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7884796..7912755)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7790128..7818165)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7788114..7816073)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7759303-7759840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11650 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7760574-7761436 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7761437-7762298 Neighboring gene transmembrane protein 88 Neighboring gene N-alpha-acetyltransferase 38, NatC auxiliary subunit Neighboring gene cytochrome b5 domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11653 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7792539-7793108 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:7797066-7798265 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:7806009-7806616 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:7806617-7807223 Neighboring gene small Cajal body-specific RNA 21 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7818325-7819258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8148 Neighboring gene ring finger protein 227 Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A severe neurocognitive phenotype caused by biallelic CHD3 variants in two siblings. Goldfarb Yaacobi R, et al. Am J Med Genet A, 2024 Apr. PMID 38116750
    2. Expressed sequence tags and chromosomal localization of cDNA clones from a subtracted retinal pigment epithelium library. Gieser L, et al. Genomics, 1992 Jul. PMID 1639417
    3. Identification of a human 17p-located cDNA encoding a protein of the Snf2-like helicase family. Aubry F, et al. Eur J Biochem, 1998 Jun 15. PMID 9688266
    4. Mi-2/NuRD: multiple complexes for many purposes. Bowen NJ, et al. Biochim Biophys Acta, 2004 Mar 15. PMID 15020045
    5. UV radiation regulates Mi-2 through protein translation and stability. Burd CJ, et al. J Biol Chem, 2008 Dec 12. PMID 18922793, Free PMC Article

    See all (184) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A severe neurocognitive phenotype caused by biallelic CHD3 variants in two siblings.
      Title: A severe neurocognitive phenotype caused by biallelic CHD3 variants in two siblings.
    2. Snijders Blok-Campeau Syndrome: Description of 20 Additional Individuals with Variants in CHD3 and Literature Review.
      Title: Snijders Blok-Campeau Syndrome: Description of 20 Additional Individuals with Variants in CHD3 and Literature Review.
    3. Inherited variants in CHD3 show variable expressivity in Snijders Blok-Campeau syndrome.
      Title: Inherited variants in CHD3 show variable expressivity in Snijders Blok-Campeau syndrome.
    4. Sequence and functional differences in the ATPase domains of CHD3 and SNF2H promise potential for selective regulability and drugability.
      Title: Sequence and functional differences in the ATPase domains of CHD3 and SNF2H promise potential for selective regulability and drugability.
    5. A second cohort of CHD3 patients expands the molecular mechanisms known to cause Snijders Blok-Campeau syndrome.
      Title: A second cohort of CHD3 patients expands the molecular mechanisms known to cause Snijders Blok-Campeau syndrome.
    6. A Multi-Trait Approach Identified Genetic Variants Including a Rare Mutation in RGS3 with Impact on Abnormalities of Cardiac Structure/Function.
      Title: A Multi-Trait Approach Identified Genetic Variants Including a Rare Mutation in RGS3 with Impact on Abnormalities of Cardiac Structure/Function.
    7. It has been proposed that the functional link between chromatin remodeling by CHD3 and deSUMOylation by SENP1 provides another level of control of gene expression.
      Title: The SUMO protease SENP1 and the chromatin remodeler CHD3 interact and jointly affect chromatin accessibility and gene expression.
    8. The tandem PHD fingers of CHD3 bind histone H3 tails.
      Title: Covalent Modifications of Histone H3K9 Promote Binding of CHD3.
    9. CHD3 and CHD4 exhibit distinct nuclear localization patterns in unperturbed cells, revealing a subset of specific target genes.
      Title: CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.
    10. Mutations in CHD3 gene is associated with cutaneous T cell lymphoma and Sezary syndrome.
      Title: The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Snijders Blok-Campeau syndrome
    MedGen: C4748701 OMIM: 618205 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag interacts with CHD3 as demonstrated by proximity dependent biotinylation proteomics PubMed
    Tat tat Depletion of CHD3 results in derepression of latent HIV-1 LTR activity PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding HDA PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell fate specification NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of stem cell differentiation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in spindle organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuRD complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuRD complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NuRD complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of NuRD complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chromodomain-helicase-DNA-binding protein 3
    Names
    ATP-dependent helicase CHD3
    CHD-3
    hZFH
    mi-2 autoantigen 240 kDa protein
    zinc finger helicase
    zinc-finger helicase (Snf2-like)
    NP_001005271.2
    NP_001005273.1
    NP_005843.2
    XP_005256484.1
    XP_005256485.1
    XP_005256486.1
    XP_005256488.1
    XP_006721486.1
    XP_006721487.1
    XP_006721491.1
    XP_016879552.1
    XP_016879553.1
    XP_016879554.1
    XP_016879555.2
    XP_016879556.1
    XP_016879557.1
    XP_016879558.1
    XP_047291146.1
    XP_047291147.1
    XP_047291148.1
    XP_047291149.1
    XP_047291150.1
    XP_047291151.1
    XP_047291152.1
    XP_047291153.1
    XP_047291154.1
    XP_047291155.1
    XP_047291156.1
    XP_047291157.1
    XP_047291158.1
    XP_047291159.1
    XP_047291160.1
    XP_047291161.1
    XP_047291162.1
    XP_047291163.1
    XP_047291164.1
    XP_047291165.1
    XP_047291166.1
    XP_047291167.1
    XP_047291168.1
    XP_047291169.1
    XP_047291170.1
    XP_047291171.1
    XP_047291172.1
    XP_054170787.1
    XP_054170788.1
    XP_054170789.1
    XP_054170790.1
    XP_054170791.1
    XP_054170792.1
    XP_054170793.1
    XP_054170794.1
    XP_054170795.1
    XP_054170796.1
    XP_054170797.1
    XP_054170798.1
    XP_054170799.1
    XP_054170800.1
    XP_054170801.1
    XP_054170802.1
    XP_054170803.1
    XP_054170804.1
    XP_054170805.1
    XP_054170806.1
    XP_054170807.1
    XP_054170808.1
    XP_054170809.1
    XP_054170810.1
    XP_054170811.1
    XP_054170812.1
    XP_054170813.1
    XP_054170814.1
    XP_054170815.1
    XP_054170816.1
    XP_054170817.1
    XP_054170818.1
    XP_054170819.1
    XP_054170820.1
    XP_054170821.1
    XP_054170822.1
    XP_054170823.1
    XP_054170824.1
    XP_054170825.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005271.3 → NP_001005271.2  chromodomain-helicase-DNA-binding protein 3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and CDS, compared to variant 1, resulting in a longer protein (isoform 3) that has a distinct N-terminus, compared to isoform 1. The transcript is supported by ESTs and an mRNA but the predicted protein has not yet been confirmed experimentally.
      Source sequence(s)
      AC104581, AF064844, AK125928, BC110648, BX283837, U91543
      Consensus CDS
      CCDS32553.2
      UniProtKB/Swiss-Prot
      Q12873
      UniProtKB/TrEMBL
      B3KWV4, Q2TAZ1
      Related
      ENSP00000369716.4, ENST00000380358.9
      Conserved Domains (11) summary
      smart00298
      Location:692 → 744
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:938 → 1317
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:815 → 973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:440 → 482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517 → 559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:798 → 1094
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1118 → 1233
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:1437 → 1576
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:1371 → 1415
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:207 → 259
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:1795 → 1966
      CHDCT2; CHDCT2 (NUC038) domain

    2. NM_001005273.3 → NP_001005273.1  chromodomain-helicase-DNA-binding protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001005273.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variant 1 encodes isoform 1.
      Source sequence(s)
      AC104581, AK125928, BC110648, U91543
      Consensus CDS
      CCDS32554.1
      UniProtKB/Swiss-Prot
      D3DTQ9, E9PG89, Q12873, Q9Y4I0
      Related
      ENSP00000332628.7, ENST00000330494.12
      Conserved Domains (11) summary
      smart00298
      Location:633 → 685
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:879 → 1258
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:756 → 914
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:381 → 423
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:458 → 500
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:739 → 1035
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1059 → 1174
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:1378 → 1517
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:1312 → 1356
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:148 → 200
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:1736 → 1907
      CHDCT2; CHDCT2 (NUC038) domain

    3. NM_005852.4 → NP_005843.2  chromodomain-helicase-DNA-binding protein 3 isoform 2

      See identical proteins and their annotated locations for NP_005843.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' CDS, compared to variant 1. The resulting protein (isoform 2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC104581, AK125928, BC110648, U91543
      Consensus CDS
      CCDS32555.1
      UniProtKB/Swiss-Prot
      Q12873
      UniProtKB/TrEMBL
      B3KWV4, Q2TAZ1
      Related
      ENSP00000350907.4, ENST00000358181.8
      Conserved Domains (12) summary
      PHA03418
      Location:1519 → 1654
      PHA03418; hypothetical E4 protein; Provisional
      smart00298
      Location:633 → 685
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:879 → 1258
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:756 → 914
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:381 → 423
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:458 → 500
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:739 → 1035
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1059 → 1174
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:1378 → 1517
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:1312 → 1356
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:148 → 200
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:1702 → 1873
      CHDCT2; CHDCT2 (NUC038) domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      7884796..7912755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005256427.5 → XP_005256484.1  chromodomain-helicase-DNA-binding protein 3 isoform X1

      Conserved Domains (11) summary
      smart00298
      Location:692 → 744
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:938 → 1317
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:815 → 973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:440 → 482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517 → 559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:798 → 1094
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1118 → 1233
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:1437 → 1576
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:1371 → 1415
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:207 → 259
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:1796 → 1923
      CHDCT2; CHDCT2 (NUC038) domain

    2. XM_005256429.5 → XP_005256486.1  chromodomain-helicase-DNA-binding protein 3 isoform X7

      Conserved Domains (11) summary
      smart00298
      Location:692 → 744
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:938 → 1317
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:815 → 973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:440 → 482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517 → 559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:798 → 1094
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1118 → 1233
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:1437 → 1576
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:1371 → 1415
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:207 → 259
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:1796 → 1967
      CHDCT2; CHDCT2 (NUC038) domain

    3. XM_006721423.4 → XP_006721486.1  chromodomain-helicase-DNA-binding protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TR54
      Related
      ENSP00000515165.1, ENST00000700753.1
      Conserved Domains (11) summary
      smart00298
      Location:692 → 744
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:938 → 1317
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:815 → 973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:440 → 482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517 → 559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:798 → 1094
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1118 → 1233
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:1437 → 1576
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:1371 → 1415
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:207 → 259
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:1795 → 1922
      CHDCT2; CHDCT2 (NUC038) domain

    4. XM_005256428.5 → XP_005256485.1  chromodomain-helicase-DNA-binding protein 3 isoform X5

      Conserved Domains (12) summary
      PHA03418
      Location:1578 → 1713
      PHA03418; hypothetical E4 protein; Provisional
      smart00298
      Location:692 → 744
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:938 → 1317
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:815 → 973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:440 → 482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517 → 559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:798 → 1094
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1118 → 1233
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:1437 → 1576
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:1371 → 1415
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:207 → 259
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:1761 → 1888
      CHDCT2; CHDCT2 (NUC038) domain

    5. XM_006721428.4 → XP_006721491.1  chromodomain-helicase-DNA-binding protein 3 isoform X22

      Conserved Domains (12) summary
      PHA03418
      Location:1578 → 1713
      PHA03418; hypothetical E4 protein; Provisional
      smart00298
      Location:692 → 744
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:938 → 1317
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:815 → 973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:440 → 482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517 → 559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:798 → 1094
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1118 → 1233
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:1437 → 1576
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:1371 → 1415
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:207 → 259
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:1761 → 1932
      CHDCT2; CHDCT2 (NUC038) domain

    6. XM_017024065.2 → XP_016879554.1  chromodomain-helicase-DNA-binding protein 3 isoform X14

    7. XM_047435206.1 → XP_047291162.1  chromodomain-helicase-DNA-binding protein 3 isoform X27

    8. XM_047435196.1 → XP_047291152.1  chromodomain-helicase-DNA-binding protein 3 isoform X15

    9. XM_047435207.1 → XP_047291163.1  chromodomain-helicase-DNA-binding protein 3 isoform X28

    10. XM_047435213.1 → XP_047291169.1  chromodomain-helicase-DNA-binding protein 3 isoform X34

    11. XM_006721424.4 → XP_006721487.1  chromodomain-helicase-DNA-binding protein 3 isoform X3

      Conserved Domains (11) summary
      smart00298
      Location:688 → 740
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:934 → 1313
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:811 → 969
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:436 → 478
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:513 → 555
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:794 → 1090
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1114 → 1229
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:1433 → 1572
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:1367 → 1411
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:207 → 259
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:1792 → 1919
      CHDCT2; CHDCT2 (NUC038) domain

    12. XM_047435192.1 → XP_047291148.1  chromodomain-helicase-DNA-binding protein 3 isoform X8

    13. XM_047435190.1 → XP_047291146.1  chromodomain-helicase-DNA-binding protein 3 isoform X4

    14. XM_017024064.2 → XP_016879553.1  chromodomain-helicase-DNA-binding protein 3 isoform X10

    15. XM_047435191.1 → XP_047291147.1  chromodomain-helicase-DNA-binding protein 3 isoform X6

    16. XM_047435202.1 → XP_047291158.1  chromodomain-helicase-DNA-binding protein 3 isoform X23

    17. XM_047435198.1 → XP_047291154.1  chromodomain-helicase-DNA-binding protein 3 isoform X18

    18. XM_047435208.1 → XP_047291164.1  chromodomain-helicase-DNA-binding protein 3 isoform X29

    19. XM_047435214.1 → XP_047291170.1  chromodomain-helicase-DNA-binding protein 3 isoform X35

    20. XM_005256431.5 → XP_005256488.1  chromodomain-helicase-DNA-binding protein 3 isoform X38

      UniProtKB/TrEMBL
      A0A5F9ZHX5
      Conserved Domains (7) summary
      smart00298
      Location:692 → 744
      CHROMO; Chromatin organization modifier domain
      cd00046
      Location:815 → 973
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:440 → 482
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:517 → 559
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:798 → 1094
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1118 → 1185
      Helicase_C; Helicase conserved C-terminal domain
      pfam08073
      Location:207 → 259
      CHDNT; CHDNT (NUC034) domain

    21. XM_047435210.1 → XP_047291166.1  chromodomain-helicase-DNA-binding protein 3 isoform X31

    22. XM_017024067.3 → XP_016879556.1  chromodomain-helicase-DNA-binding protein 3 isoform X17

      Conserved Domains (11) summary
      smart00298
      Location:622 → 674
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:868 → 1247
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:745 → 903
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:370 → 412
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:447 → 489
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:728 → 1024
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1048 → 1163
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:1367 → 1506
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:1301 → 1345
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:137 → 189
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:1726 → 1853
      CHDCT2; CHDCT2 (NUC038) domain

    23. XM_017024068.2 → XP_016879557.1  chromodomain-helicase-DNA-binding protein 3 isoform X19

      Conserved Domains (11) summary
      smart00298
      Location:613 → 665
      CHROMO; Chromatin organization modifier domain
      COG1111
      Location:859 → 1238
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:736 → 894
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15531
      Location:361 → 403
      PHD1_CHD_II; PHD finger 1 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      cd15532
      Location:438 → 480
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:719 → 1015
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:1039 → 1154
      Helicase_C; Helicase conserved C-terminal domain
      pfam06461
      Location:1358 → 1497
      DUF1086; Domain of Unknown Function (DUF1086)
      pfam06465
      Location:1292 → 1336
      DUF1087; Domain of Unknown Function (DUF1087)
      pfam08073
      Location:128 → 180
      CHDNT; CHDNT (NUC034) domain
      pfam08074
      Location:1717 → 1844
      CHDCT2; CHDCT2 (NUC038) domain

    24. XM_047435211.1 → XP_047291167.1  chromodomain-helicase-DNA-binding protein 3 isoform X32

    25. XM_047435204.1 → XP_047291160.1  chromodomain-helicase-DNA-binding protein 3 isoform X25

    26. XM_047435197.1 → XP_047291153.1  chromodomain-helicase-DNA-binding protein 3 isoform X17

    27. XM_047435199.1 → XP_047291155.1  chromodomain-helicase-DNA-binding protein 3 isoform X19

    28. XM_047435209.1 → XP_047291165.1  chromodomain-helicase-DNA-binding protein 3 isoform X30

    29. XM_047435200.1 → XP_047291156.1  chromodomain-helicase-DNA-binding protein 3 isoform X20

    30. XM_047435201.1 → XP_047291157.1  chromodomain-helicase-DNA-binding protein 3 isoform X21

    31. XM_047435215.1 → XP_047291171.1  chromodomain-helicase-DNA-binding protein 3 isoform X36

    32. XM_047435216.1 → XP_047291172.1  chromodomain-helicase-DNA-binding protein 3 isoform X37

    33. XM_017024066.2 → XP_016879555.2  chromodomain-helicase-DNA-binding protein 3 isoform X16

    34. XM_017024069.2 → XP_016879558.1  chromodomain-helicase-DNA-binding protein 3 isoform X37

    35. XM_017024063.2 → XP_016879552.1  chromodomain-helicase-DNA-binding protein 3 isoform X9

    36. XM_047435193.1 → XP_047291149.1  chromodomain-helicase-DNA-binding protein 3 isoform X11

    37. XM_047435194.1 → XP_047291150.1  chromodomain-helicase-DNA-binding protein 3 isoform X12

    38. XM_047435203.1 → XP_047291159.1  chromodomain-helicase-DNA-binding protein 3 isoform X24

    39. XM_047435195.1 → XP_047291151.1  chromodomain-helicase-DNA-binding protein 3 isoform X13

    40. XM_047435205.1 → XP_047291161.1  chromodomain-helicase-DNA-binding protein 3 isoform X26

    41. XM_047435212.1 → XP_047291168.1  chromodomain-helicase-DNA-binding protein 3 isoform X33

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      7790128..7818165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314812.1 → XP_054170787.1  chromodomain-helicase-DNA-binding protein 3 isoform X1

    2. XM_054314818.1 → XP_054170793.1  chromodomain-helicase-DNA-binding protein 3 isoform X7

    3. XM_054314813.1 → XP_054170788.1  chromodomain-helicase-DNA-binding protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8V8TR54

    4. XM_054314816.1 → XP_054170791.1  chromodomain-helicase-DNA-binding protein 3 isoform X5

    5. XM_054314834.1 → XP_054170809.1  chromodomain-helicase-DNA-binding protein 3 isoform X22

    6. XM_054314825.1 → XP_054170800.1  chromodomain-helicase-DNA-binding protein 3 isoform X14

    7. XM_054314839.1 → XP_054170814.1  chromodomain-helicase-DNA-binding protein 3 isoform X27

    8. XM_054314826.1 → XP_054170801.1  chromodomain-helicase-DNA-binding protein 3 isoform X15

    9. XM_054314840.1 → XP_054170815.1  chromodomain-helicase-DNA-binding protein 3 isoform X28

    10. XM_054314846.1 → XP_054170821.1  chromodomain-helicase-DNA-binding protein 3 isoform X34

    11. XM_054314814.1 → XP_054170789.1  chromodomain-helicase-DNA-binding protein 3 isoform X3

    12. XM_054314819.1 → XP_054170794.1  chromodomain-helicase-DNA-binding protein 3 isoform X8

    13. XM_054314815.1 → XP_054170790.1  chromodomain-helicase-DNA-binding protein 3 isoform X4

    14. XM_054314821.1 → XP_054170796.1  chromodomain-helicase-DNA-binding protein 3 isoform X10

    15. XM_054314817.1 → XP_054170792.1  chromodomain-helicase-DNA-binding protein 3 isoform X6

    16. XM_054314835.1 → XP_054170810.1  chromodomain-helicase-DNA-binding protein 3 isoform X23

    17. XM_054314829.1 → XP_054170804.1  chromodomain-helicase-DNA-binding protein 3 isoform X18

    18. XM_054314841.1 → XP_054170816.1  chromodomain-helicase-DNA-binding protein 3 isoform X29

    19. XM_054314847.1 → XP_054170822.1  chromodomain-helicase-DNA-binding protein 3 isoform X35

    20. XM_054314850.1 → XP_054170825.1  chromodomain-helicase-DNA-binding protein 3 isoform X38

    21. XM_054314843.1 → XP_054170818.1  chromodomain-helicase-DNA-binding protein 3 isoform X31

    22. XM_054314831.1 → XP_054170806.1  chromodomain-helicase-DNA-binding protein 3 isoform X19

    23. XM_054314830.1 → XP_054170805.1  chromodomain-helicase-DNA-binding protein 3 isoform X19

    24. XM_054314844.1 → XP_054170819.1  chromodomain-helicase-DNA-binding protein 3 isoform X32

    25. XM_054314837.1 → XP_054170812.1  chromodomain-helicase-DNA-binding protein 3 isoform X25

    26. XM_054314842.1 → XP_054170817.1  chromodomain-helicase-DNA-binding protein 3 isoform X30

    27. XM_054314832.1 → XP_054170807.1  chromodomain-helicase-DNA-binding protein 3 isoform X20

    28. XM_054314833.1 → XP_054170808.1  chromodomain-helicase-DNA-binding protein 3 isoform X21

    29. XM_054314848.1 → XP_054170823.1  chromodomain-helicase-DNA-binding protein 3 isoform X36

    30. XM_054314828.1 → XP_054170803.1  chromodomain-helicase-DNA-binding protein 3 isoform X17

    31. XM_054314849.1 → XP_054170824.1  chromodomain-helicase-DNA-binding protein 3 isoform X37

    32. XM_054314820.1 → XP_054170795.1  chromodomain-helicase-DNA-binding protein 3 isoform X9

    33. XM_054314822.1 → XP_054170797.1  chromodomain-helicase-DNA-binding protein 3 isoform X11

    34. XM_054314823.1 → XP_054170798.1  chromodomain-helicase-DNA-binding protein 3 isoform X12

    35. XM_054314836.1 → XP_054170811.1  chromodomain-helicase-DNA-binding protein 3 isoform X24

    36. XM_054314824.1 → XP_054170799.1  chromodomain-helicase-DNA-binding protein 3 isoform X13

    37. XM_054314838.1 → XP_054170813.1  chromodomain-helicase-DNA-binding protein 3 isoform X26

    38. XM_054314845.1 → XP_054170820.1  chromodomain-helicase-DNA-binding protein 3 isoform X33

    39. XM_054314827.1 → XP_054170802.1  chromodomain-helicase-DNA-binding protein 3 isoform X39

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001272.1: Suppressed sequence

      Description
      NM_001272.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12873.3 GenPept UniProtKB/Swiss-Prot:Q12873

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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