U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    SRSF5 serine and arginine rich splicing factor 5 [ Homo sapiens (human) ]

    Gene ID: 6430, updated on 9-Dec-2024

    Summary

    Official Symbol
    SRSF5provided by HGNC
    Official Full Name
    serine and arginine rich splicing factor 5provided by HGNC
    Primary source
    HGNC:HGNC:10787
    See related
    Ensembl:ENSG00000100650 MIM:600914; AllianceGenome:HGNC:10787
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HRS; SFRS5; SRP40
    Summary
    The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
    Expression
    Ubiquitous expression in bone marrow (RPKM 175.0), skin (RPKM 153.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SRSF5 in Genome Data Viewer
    Location:
    14q24.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (69767142..69772005)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (63934566..63979677)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (70233859..70238722)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 177 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:70061623-70061793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:70088656-70089156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8640 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8641 Neighboring gene sushi domain containing 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:70104475-70104987 Neighboring gene Sharpr-MPRA regulatory region 10837 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:70124416-70125196 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8644 Neighboring gene Sharpr-MPRA regulatory region 2331 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8646 Neighboring gene Sharpr-MPRA regulatory region 930 Neighboring gene Sharpr-MPRA regulatory region 8327 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:70207027-70208226 Neighboring gene uncharacterized LOC100289511 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8648 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:70233975-70234739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8649 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:70237232-70238431 Neighboring gene solute carrier family 10 member 1 Neighboring gene Sharpr-MPRA regulatory region 10266 Neighboring gene small nucleolar RNA SNORA11

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env The bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates HIV-1 rev, env, vpu, and nef gene expression PubMed
    Nef nef The bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates HIV-1 rev, env, vpu, and nef gene expression PubMed
    Pr55(Gag) gag Human CRM1 and SRp40 increase the amount of unspliced HIV-1 RNA and have a more-than-additive effect on HIV-1 titers in mouse cells PubMed
    gag SR proteins, particularly SRp40 and SRp55, increase HIV-1 Gag translation from unspliced viral RNA. The second RNA recognition motif and the arginine-serine (RS) domain are determinants of SR protein activity PubMed
    Rev rev SF2/ASF and SRp40 interact with a purine-rich motif within the HIV-1 exon 5, and this interaction activates splicing at an upstream 3' splice site and binding of the 5' splice site to U1 snRNP, which are required for splicing of HIV-1 rev and nef mRNAs PubMed
    Vpu vpu The bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates HIV-1 rev, env, vpu, and nef gene expression PubMed
    capsid gag Human CRM1 and SRp40 have a more-than-additive effect on HIV-1 CA production in mouse cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mRNA processing TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mRNA splice site recognition TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    serine/arginine-rich splicing factor 5
    Names
    SR splicing factor 5
    delayed-early protein HRS
    pre-mRNA-splicing factor SRP40
    splicing factor, arginine/serine-rich 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039465.2NP_001034554.1  serine/arginine-rich splicing factor 5 isoform 1

      See identical proteins and their annotated locations for NP_001034554.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AA640719, BC018823, BU928782
      Consensus CDS
      CCDS32109.1
      UniProtKB/Swiss-Prot
      O14797, Q13243, Q16662, Q49AD6, Q6FGE0
      Related
      ENSP00000377892.2, ENST00000394366.6
      Conserved Domains (2) summary
      cd12595
      Location:574
      RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
      cd12765
      Location:99179
      RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    2. NM_001320214.2NP_001307143.1  serine/arginine-rich splicing factor 5 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL157789, BC040209, DC307911
      Consensus CDS
      CCDS32109.1
      UniProtKB/Swiss-Prot
      O14797, Q13243, Q16662, Q49AD6, Q6FGE0
      Related
      ENSP00000451088.1, ENST00000557154.6
      Conserved Domains (2) summary
      cd12595
      Location:574
      RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
      cd12765
      Location:99179
      RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    3. NM_001411040.1NP_001397969.1  serine/arginine-rich splicing factor 5 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL157789
      Consensus CDS
      CCDS91892.1
      UniProtKB/TrEMBL
      B4DUA4
    4. NM_006925.5NP_008856.2  serine/arginine-rich splicing factor 5 isoform 1

      See identical proteins and their annotated locations for NP_008856.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL157789, BX407495, DR761538
      Consensus CDS
      CCDS32109.1
      UniProtKB/Swiss-Prot
      O14797, Q13243, Q16662, Q49AD6, Q6FGE0
      Related
      ENSP00000451391.1, ENST00000553635.5
      Conserved Domains (2) summary
      cd12595
      Location:574
      RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
      cd12765
      Location:99179
      RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      69767142..69772005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021593.3XP_016877082.1  serine/arginine-rich splicing factor 5 isoform X1

      Related
      ENST00000556587.5
      Conserved Domains (2) summary
      cd12595
      Location:574
      RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
      cd12765
      Location:99179
      RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    2. XM_005267999.3XP_005268056.1  serine/arginine-rich splicing factor 5 isoform X1

      See identical proteins and their annotated locations for XP_005268056.1

      Conserved Domains (2) summary
      cd12595
      Location:574
      RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
      cd12765
      Location:99179
      RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    3. XM_011537077.4XP_011535379.1  serine/arginine-rich splicing factor 5 isoform X2

      See identical proteins and their annotated locations for XP_011535379.1

      Conserved Domains (2) summary
      cd12337
      Location:566
      RRM1_SRSF4_like; RNA recognition motif 1 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
      cd12600
      Location:75145
      RRM2_SRSF4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor 4 (SRSF4) and similar proteins
    4. XM_005268000.3XP_005268057.1  serine/arginine-rich splicing factor 5 isoform X1

      See identical proteins and their annotated locations for XP_005268057.1

      Conserved Domains (2) summary
      cd12595
      Location:574
      RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
      cd12765
      Location:99179
      RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
    5. XM_047431683.1XP_047287639.1  serine/arginine-rich splicing factor 5 isoform X2

    6. XM_047431684.1XP_047287640.1  serine/arginine-rich splicing factor 5 isoform X4

      UniProtKB/TrEMBL
      B4DUA4
      Related
      ENSP00000452449.1, ENST00000553369.5
    7. XM_047431685.1XP_047287641.1  serine/arginine-rich splicing factor 5 isoform X4

      UniProtKB/TrEMBL
      B4DUA4
      Related
      ENSP00000450918.1, ENST00000554021.1
    8. XM_017021594.3XP_016877083.1  serine/arginine-rich splicing factor 5 isoform X3

      UniProtKB/TrEMBL
      Q86U32
      Conserved Domains (1) summary
      cl17169
      Location:151
      RRM_SF; RNA recognition motif (RRM) superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      63934566..63979677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376577.1XP_054232552.1  serine/arginine-rich splicing factor 5 isoform X5

      UniProtKB/Swiss-Prot
      O14797, Q13243, Q16662, Q49AD6, Q6FGE0
    2. XM_054376578.1XP_054232553.1  serine/arginine-rich splicing factor 5 isoform X5

      UniProtKB/Swiss-Prot
      O14797, Q13243, Q16662, Q49AD6, Q6FGE0
    3. XM_054376581.1XP_054232556.1  serine/arginine-rich splicing factor 5 isoform X1

    4. XM_054376583.1XP_054232558.1  serine/arginine-rich splicing factor 5 isoform X2

    5. XM_054376586.1XP_054232561.1  serine/arginine-rich splicing factor 5 isoform X4

      UniProtKB/TrEMBL
      B4DUA4
    6. XM_054376579.1XP_054232554.1  serine/arginine-rich splicing factor 5 isoform X1

    7. XM_054376582.1XP_054232557.1  serine/arginine-rich splicing factor 5 isoform X2

    8. XM_054376585.1XP_054232560.1  serine/arginine-rich splicing factor 5 isoform X4

      UniProtKB/TrEMBL
      B4DUA4
    9. XM_054376580.1XP_054232555.1  serine/arginine-rich splicing factor 5 isoform X1

    10. XM_054376584.1XP_054232559.1  serine/arginine-rich splicing factor 5 isoform X3

      UniProtKB/TrEMBL
      Q86U32