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    CCDC15 coiled-coil domain containing 15 [ Homo sapiens (human) ]

    Gene ID: 80071, updated on 10-Dec-2024

    Summary

    Official Symbol
    CCDC15provided by HGNC
    Official Full Name
    coiled-coil domain containing 15provided by HGNC
    Primary source
    HGNC:HGNC:25798
    See related
    Ensembl:ENSG00000149548 AllianceGenome:HGNC:25798
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Located in centrosome. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 5.0), skin (RPKM 0.7) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CCDC15 in Genome Data Viewer
    Location:
    11q24.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (124954202..125041489)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (124982721..125070161)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (124824098..124911385)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984406 Neighboring gene hepatic and glial cell adhesion molecule Neighboring gene hepatocellular carcinoma, down-regulated 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:124823758-124824301 Neighboring gene CCDC15 divergent transcript Neighboring gene MPRA-validated peak1499 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:124853252-124854004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4037 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5693 Neighboring gene solute carrier family 37 member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:124951446-124951995 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:124952423-124953622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5694 Neighboring gene transmembrane protein 218

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13215

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    coiled-coil domain-containing protein 15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052613.1 RefSeqGene

      Range
      5082..92369
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_025004.3NP_079280.2  coiled-coil domain-containing protein 15

      See identical proteins and their annotated locations for NP_079280.2

      Status: VALIDATED

      Source sequence(s)
      AK023277, AP003501, AW339835, BC018540, BU569785, DB516555
      Consensus CDS
      CCDS44756.1
      UniProtKB/Swiss-Prot
      Q0P6D6, Q9H8U7
      UniProtKB/TrEMBL
      E9PKB1
      Related
      ENSP00000341684.5, ENST00000344762.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      124954202..125041489
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018346.2XP_016873835.1  coiled-coil domain-containing protein 15 isoform X1

      UniProtKB/TrEMBL
      E9PKB1
    2. XM_017018348.2XP_016873837.1  coiled-coil domain-containing protein 15 isoform X3

    3. XM_047427627.1XP_047283583.1  coiled-coil domain-containing protein 15 isoform X5

    4. XM_017018350.2XP_016873839.1  coiled-coil domain-containing protein 15 isoform X6

    5. XM_017018351.2XP_016873840.1  coiled-coil domain-containing protein 15 isoform X8

    6. XM_017018353.2XP_016873842.1  coiled-coil domain-containing protein 15 isoform X10

    7. XM_017018347.2XP_016873836.1  coiled-coil domain-containing protein 15 isoform X2

    8. XM_047427628.1XP_047283584.1  coiled-coil domain-containing protein 15 isoform X7

    9. XM_047427630.1XP_047283586.1  coiled-coil domain-containing protein 15 isoform X11

    10. XM_017018352.2XP_016873841.1  coiled-coil domain-containing protein 15 isoform X9

    11. XM_017018349.2XP_016873838.1  coiled-coil domain-containing protein 15 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      124982721..125070161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370014.1XP_054225989.1  coiled-coil domain-containing protein 15 isoform X1

      UniProtKB/TrEMBL
      E9PKB1
    2. XM_054370016.1XP_054225991.1  coiled-coil domain-containing protein 15 isoform X3

    3. XM_054370018.1XP_054225993.1  coiled-coil domain-containing protein 15 isoform X5

    4. XM_054370019.1XP_054225994.1  coiled-coil domain-containing protein 15 isoform X6

    5. XM_054370021.1XP_054225996.1  coiled-coil domain-containing protein 15 isoform X8

    6. XM_054370023.1XP_054225998.1  coiled-coil domain-containing protein 15 isoform X10

    7. XM_054370015.1XP_054225990.1  coiled-coil domain-containing protein 15 isoform X2

      UniProtKB/TrEMBL
      E9PKB1
    8. XM_054370020.1XP_054225995.1  coiled-coil domain-containing protein 15 isoform X7

    9. XM_054370024.1XP_054225999.1  coiled-coil domain-containing protein 15 isoform X11

    10. XM_054370022.1XP_054225997.1  coiled-coil domain-containing protein 15 isoform X9

    11. XM_054370017.1XP_054225992.1  coiled-coil domain-containing protein 15 isoform X4