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    INCENP inner centromere protein [ Homo sapiens (human) ]

    Gene ID: 3619, updated on 10-Dec-2024

    Summary

    Official Symbol
    INCENPprovided by HGNC
    Official Full Name
    inner centromere proteinprovided by HGNC
    Primary source
    HGNC:HGNC:6058
    See related
    Ensembl:ENSG00000149503 MIM:604411; AllianceGenome:HGNC:6058
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 6.2), esophagus (RPKM 5.2) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See INCENP in Genome Data Viewer
    Location:
    11q12.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62124011..62153169)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62113566..62142731)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (61891483..61920641)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2733 Neighboring gene NANOG hESC enhancer GRCh37_chr11:61870547-61871048 Neighboring gene uncharacterized LOC124902681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4812 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:61891773-61892354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61895837-61896336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61897363-61897864 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:61912955-61913116 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:61942903-61943082 Neighboring gene eukaryotic translation elongation factor 1 delta pseudogene 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61959742-61960242 Neighboring gene secretoglobin family 1D member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
    EBI GWAS Catalog
    Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr upregulates INCENP in HeLa cells within 12 hours of exposure PubMed
    vpr HIV-1 Vpr interferes with the heterochromatin structure by displacing HP1-alpha and HP1-gamma proteins in interphase, which leads to relocalization of the centromere chromatin proteins Mis12, Sgo1, and INCENP/CPC after prophase PubMed
    vpr AurB and INCENP proteins targeting the inner centromere are reduced significantly in HIV-1 Vpr-expressing prometaphase cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ31633, MGC111393

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular function activator activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in central element IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromocenter IEA
    Inferred from Electronic Annotation
    more info
     
    part_of chromosome passenger complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of chromosome passenger complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lateral element IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in meiotic spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in midbody IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in midbody IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    inner centromere protein
    Names
    binds and activates aurora-B and -C in vivo and in vitro
    chromosomal passenger protein
    inner centromere protein INCENP
    inner centromere protein antigens 135/155kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040694.2NP_001035784.1  inner centromere protein isoform 1

      See identical proteins and their annotated locations for NP_001035784.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AP002793, AW839685, BC098576, BC111732, CV569756
      Consensus CDS
      CCDS44624.1
      UniProtKB/Swiss-Prot
      A8MQD2, Q5Y192, Q9NQS7
      Related
      ENSP00000378295.3, ENST00000394818.8
      Conserved Domains (2) summary
      pfam03941
      Location:831882
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam12178
      Location:641
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
    2. NM_020238.3NP_064623.2  inner centromere protein isoform 2

      See identical proteins and their annotated locations for NP_064623.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AP002793, AW839685, BC032678, BC098576, BC111732, CV569756
      Consensus CDS
      CCDS31582.1
      UniProtKB/Swiss-Prot
      Q9NQS7
      Related
      ENSP00000278849.4, ENST00000278849.5
      Conserved Domains (3) summary
      pfam03941
      Location:827878
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam12178
      Location:641
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
      cl00583
      Location:520613
      PhaG_MnhG_YufB; Na+/H+ antiporter subunit

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      62124011..62153169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544995.4XP_011543297.1  inner centromere protein isoform X1

      Conserved Domains (2) summary
      pfam03941
      Location:846897
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam12178
      Location:641
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
    2. XM_006718533.4XP_006718596.1  inner centromere protein isoform X5

      Conserved Domains (2) summary
      pfam03941
      Location:835886
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam12178
      Location:641
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
    3. XM_011544996.4XP_011543298.1  inner centromere protein isoform X3

      Conserved Domains (2) summary
      pfam03941
      Location:842893
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam12178
      Location:641
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
    4. XM_011544997.3XP_011543299.1  inner centromere protein isoform X2

      Conserved Domains (3) summary
      pfam03941
      Location:842893
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam12178
      Location:641
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
      cl00583
      Location:520613
      PhaG_MnhG_YufB; Na+/H+ antiporter subunit
    5. XM_047426886.1XP_047282842.1  inner centromere protein isoform X6

    6. XM_011544998.4XP_011543300.1  inner centromere protein isoform X4

      Conserved Domains (3) summary
      pfam03941
      Location:838889
      INCENP_ARK-bind; Inner centromere protein, ARK binding region
      pfam12178
      Location:641
      INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
      cl00583
      Location:520613
      PhaG_MnhG_YufB; Na+/H+ antiporter subunit

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      62113566..62142731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368673.1XP_054224648.1  inner centromere protein isoform X1

    2. XM_054368677.1XP_054224652.1  inner centromere protein isoform X5

    3. XM_054368675.1XP_054224650.1  inner centromere protein isoform X3

    4. XM_054368674.1XP_054224649.1  inner centromere protein isoform X2

    5. XM_054368678.1XP_054224653.1  inner centromere protein isoform X6

    6. XM_054368676.1XP_054224651.1  inner centromere protein isoform X4