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    TTC24 tetratricopeptide repeat domain 24 [ Homo sapiens (human) ]

    Gene ID: 164118, updated on 27-Nov-2024

    Summary

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    Official Symbol
    TTC24provided by HGNC
    Official Full Name
    tetratricopeptide repeat domain 24provided by HGNC
    Primary source
    HGNC:HGNC:32348
    See related
    Ensembl:ENSG00000187862 AllianceGenome:HGNC:32348
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in lymph node (RPKM 3.0), spleen (RPKM 1.9) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TTC24 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156579723..156587719)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155716091..155724195)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156549515..156557511)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156432711-156433660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156445026-156445638 Neighboring gene myocyte enhancer factor 2D Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1864 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1866 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156466171-156466671 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1428 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156471045-156471824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1868 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:156474933-156475335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1870 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1869 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:156483472-156483678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1430 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:156495835-156496406 Neighboring gene small nucleolar RNA U13 Neighboring gene IQ motif containing GTPase activating protein 3 Neighboring gene NANOG hESC enhancer GRCh37_chr1:156508711-156509291 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1871 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1872 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1873 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156554411-156554912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156554913-156555412 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156561722-156562568 Neighboring gene G-patch domain containing 4 (gene/pseudogene) Neighboring gene NAD(P)HX epimerase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
    2. In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker. Gao H, et al. Anal Chem, 2022 May 31. PMID 35575683

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ20249

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 24
    Names
    TPR repeat protein 24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105669.4 → NP_001099139.2  tetratricopeptide repeat protein 24

      See identical proteins and their annotated locations for NP_001099139.2

      Status: VALIDATED

      Source sequence(s)
      AL365181
      Consensus CDS
      CCDS53379.1
      UniProtKB/Swiss-Prot
      A2A3L6, Q5T3H7
      Related
      ENSP00000357219.3, ENST00000368236.8
      Conserved Domains (5) summary
      smart00028
      Location:273 → 302
      TPR; Tetratricopeptide repeats
      sd00006
      Location:273 → 301
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:353 → 380
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:121 → 180
      TPR_11; TPR repeat
      pfam13424
      Location:271 → 345
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      156579723..156587719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047447969.1 → XP_047303925.1  tetratricopeptide repeat protein 24 isoform X3

    2. XM_011509253.3 → XP_011507555.2  tetratricopeptide repeat protein 24 isoform X1

    3. XM_011509255.3 → XP_011507557.2  tetratricopeptide repeat protein 24 isoform X4

    4. XM_047447973.1 → XP_047303929.1  tetratricopeptide repeat protein 24 isoform X6

    5. XM_011509254.3 → XP_011507556.2  tetratricopeptide repeat protein 24 isoform X2

    6. XM_047447971.1 → XP_047303927.1  tetratricopeptide repeat protein 24 isoform X5

    7. XM_047447977.1 → XP_047303933.1  tetratricopeptide repeat protein 24 isoform X8

    8. XM_047447975.1 → XP_047303931.1  tetratricopeptide repeat protein 24 isoform X7

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791758.1 Reference GRCh38.p14 PATCHES

      Range
      138280..146384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332835.1 → XP_054188810.1  tetratricopeptide repeat protein 24 isoform X3

    2. XM_054332840.1 → XP_054188815.1  tetratricopeptide repeat protein 24 isoform X8

    3. XM_054332833.1 → XP_054188808.1  tetratricopeptide repeat protein 24 isoform X1

    4. XM_054332836.1 → XP_054188811.1  tetratricopeptide repeat protein 24 isoform X4

    5. XM_054332838.1 → XP_054188813.1  tetratricopeptide repeat protein 24 isoform X6

    6. XM_054332834.1 → XP_054188809.1  tetratricopeptide repeat protein 24 isoform X2

    7. XM_054332837.1 → XP_054188812.1  tetratricopeptide repeat protein 24 isoform X5

    8. XM_054332839.1 → XP_054188814.1  tetratricopeptide repeat protein 24 isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      155716091..155724195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334786.1 → XP_054190761.1  tetratricopeptide repeat protein 24 isoform X3

    2. XM_054334791.1 → XP_054190766.1  tetratricopeptide repeat protein 24 isoform X8

    3. XM_054334784.1 → XP_054190759.1  tetratricopeptide repeat protein 24 isoform X1

    4. XM_054334787.1 → XP_054190762.1  tetratricopeptide repeat protein 24 isoform X4

    5. XM_054334789.1 → XP_054190764.1  tetratricopeptide repeat protein 24 isoform X6

    6. XM_054334785.1 → XP_054190760.1  tetratricopeptide repeat protein 24 isoform X2

    7. XM_054334788.1 → XP_054190763.1  tetratricopeptide repeat protein 24 isoform X5

    8. XM_054334790.1 → XP_054190765.1  tetratricopeptide repeat protein 24 isoform X7

    RNA

    1. XR_008485940.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A3L6.1 GenPept UniProtKB/Swiss-Prot:A2A3L6

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