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    Cyp4ac1 Cytochrome P450 4ac1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33754, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp4ac1provided by FlyBase
    Official Full Name
    Cytochrome P450 4ac1provided by FlyBase
    Primary source
    FLYBASE:FBgn0031693
    Locus tag
    Dmel_CG14032
    See related
    AllianceGenome:FB:FBgn0031693
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4ac1; CG14032; cyp4ac1; Cyp4AC1; CYP4ac1; Dmel\CG14032
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp4ac1 in Genome Data Viewer
    Location:
    25D2-25D2; 2-16 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5264001..5265899)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5264001..5265899)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene thickveins Neighboring gene pseudo Neighboring gene long non-coding RNA:CR44744 Neighboring gene Cytochrome P450 4ac2 Neighboring gene Cytochrome P450 4ac3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and down-regulation of cytochrome P450 genes of the CYP4 family by ecdysteroid agonists in Spodoptera littoralis and Drosophila melanogaster. Davies L, et al. Insect Biochem Mol Biol, 2006 Oct. PMID 17027846
    2. Metabolic activation and toxicological evaluation of polychlorinated biphenyls in Drosophila melanogaster. Idda T, et al. Sci Rep, 2020 Dec 9. PMID 33299007, Free PMC Article
    3. Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development. Zhang D, et al. Chromosoma, 2011 Feb. PMID 20857302
    4. Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway. Jones RM, et al. Cell Rep, 2015 Aug 25. PMID 26279578, Free PMC Article
    5. Buffering of Genetic Regulatory Networks in Drosophila melanogaster. Fear JM, et al. Genetics, 2016 Jul. PMID 27194752, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4ac1
    Names
    CG14032-PA
    Cyp4ac1-PA
    NP_608916.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5264001..5265899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135072.2 → NP_608916.1  cytochrome P450 4ac1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608916.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VMS9
      Related
      FBpp0078701, FBtr0079066
      Conserved Domains (1) summary
      pfam00067
      Location:86 → 504
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMS9.1 Q9VMS9

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