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    Klhl6 kelch-like 6 [ Mus musculus (house mouse) ]

    Gene ID: 239743, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Klhl6provided by MGI
    Official Full Name
    kelch-like 6provided by MGI
    Primary source
    MGI:MGI:2686922
    See related
    Ensembl:ENSMUSG00000043008 AllianceGenome:MGI:2686922
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in B cell receptor signaling pathway and germinal center formation. Acts upstream of or within response to bacterium. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in blood vessel; notochord; and thymus primordium. Orthologous to human KLHL6 (kelch like family member 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thymus adult (RPKM 18.2), spleen adult (RPKM 14.8) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klhl6 in Genome Data Viewer
    Location:
    16 A3; 16 12.32 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (19765242..19801766, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (19946492..19983049, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40305 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 Neighboring gene STARR-seq mESC enhancer starr_40307 Neighboring gene RIKEN cDNA A930003A15 gene Neighboring gene STARR-seq mESC enhancer starr_40308 Neighboring gene STARR-seq mESC enhancer starr_40309 Neighboring gene STARR-positive B cell enhancer ABC_E2456 Neighboring gene STARR-positive B cell enhancer ABC_E1183 Neighboring gene kelch-like 24 Neighboring gene YEATS domain containing 2 Neighboring gene SMT3 suppressor of mif two 3 homolog 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells. Gupta-Rossi N, et al. Mol Immunol, 2003 Mar. PMID 12617994
    2. The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation. Kroll J, et al. Mol Cell Biol, 2005 Oct. PMID 16166635, Free PMC Article
    3. Klhl6 Deficiency Impairs Transitional B Cell Survival and Differentiation. Bertocci B, et al. J Immunol, 2017 Oct 1. PMID 28807996
    4. An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes. Sharma PR, et al. Endocrinology, 2015 Sep. PMID 26018251, Free PMC Article
    5. The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation. Costello I, et al. Nat Cell Biol, 2011 Aug 7. PMID 21822279, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (9) 
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC118659

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germinal center formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417212.1 → NP_001404141.1  kelch-like protein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165282

    2. NM_001417213.1 → NP_001404142.1  kelch-like protein 6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC165282

    3. NM_001417214.1 → NP_001404143.1  kelch-like protein 6 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC165282

    4. NM_001417215.1 → NP_001404144.1  kelch-like protein 6 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC165282

    5. NM_001417216.1 → NP_001404145.1  kelch-like protein 6 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC165282

    6. NM_183390.4 → NP_899246.2  kelch-like protein 6 isoform 1

      See identical proteins and their annotated locations for NP_899246.2

      Status: VALIDATED

      Source sequence(s)
      AC165282
      Consensus CDS
      CCDS28041.2
      UniProtKB/Swiss-Prot
      Q497G3, Q6V595
      Related
      ENSMUSP00000053023.9, ENSMUST00000058839.10
      Conserved Domains (6) summary
      smart00612
      Location:420 → 466
      Kelch; Kelch domain
      smart00225
      Location:71 → 163
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00038
      Location:368 → 405
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:60 → 163
      BTB; BTB/POZ domain
      pfam01344
      Location:457 → 501
      Kelch_1; Kelch motif
      pfam07707
      Location:172 → 274
      BACK; BTB And C-terminal Kelch

    RNA

    1. NR_184432.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC165282

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      19765242..19801766 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159920.1 → XP_036015813.1  kelch-like protein 6 isoform X2

      Conserved Domains (5) summary
      PHA03098
      Location:11 → 487
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:292 → 329
      Kelch; KELCH repeat [structural motif]
      cl38908
      Location:20 → 98
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam01344
      Location:470 → 507
      Kelch_1; Kelch motif
      cl28903
      Location:91 → 198
      BACK; BACK (BTB and C-terminal Kelch) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6V595.2 GenPept UniProtKB/Swiss-Prot:Q6V595

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