Zic5 zinc finger protein of the cerebellum 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zic5provided by MGI
Official Full Name: zinc finger protein of the cerebellum 5provided by MGI
Primary source: MGI:MGI:1929518
See related: Ensembl:ENSMUSG00000041703 AllianceGenome:MGI:1929518
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Opr; 1700049L20Rik
Summary: Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within forebrain development; neural crest cell differentiation; and neural tube closure. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; limb mesenchyme; sensory organ; and trunk paraxial mesenchyme. Orthologous to human ZIC5 (Zic family member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 7.5), cerebellum adult (RPKM 5.7) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 E5; 14 65.96 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (122696572..122703127, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (122459160..122465658, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-101-3p inhibits nasopharyngeal carcinoma cell proliferation and cisplatin resistance through ZIC5 down-regulation by targeting SOX2.
Title: MicroRNA-101-3p inhibits nasopharyngeal carcinoma cell proliferation and cisplatin resistance through ZIC5 down-regulation by targeting SOX2.
SUMOylation Potentiates ZIC Protein Activity to Influence Murine Neural Crest Cell Specification.
Title: SUMOylation Potentiates ZIC Protein Activity to Influence Murine Neural Crest Cell Specification.
findings suggested that Zic5 is involved in the generation of neural crest tissue in mouse development
Title: Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives.
Results describe the molecular properties of Zic4 and Zic5 proteins.
Title: Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

General gene information

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Markers

BB391594 (e-PCR)
- UniSTS:208678

NoName (e-PCR)
- UniSTS:548443

NoName (e-PCR)
- UniSTS:548444

UniSTS:496750 (e-PCR)
- UniSTS:496750

Zic5 (e-PCR), detects polymorphism
- UniSTS:496750

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein ZIC 5

Names: Zic family member 5 (odd-paired homolog, Drosophila); odd paired-related protein; odd-paired related; opa-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022987.3 → NP_075363.1 zinc finger protein ZIC 5

See identical proteins and their annotated locations for NP_075363.1

Status: VALIDATED

Source sequence(s)

AC154683

Consensus CDS

CCDS27348.1

UniProtKB/Swiss-Prot

Q7TQ40, Q9EQW1

UniProtKB/TrEMBL

A0A0R4J0E2

Related

ENSMUSP00000035754.7, ENSMUST00000039118.7

Conserved Domains (4) summary

COG5048
Location:388 → 550

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:424 → 444

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:510 → 534

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:466 → 493

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

122696572..122703127 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006519357.5 → XP_006519420.1 zinc finger protein ZIC 5 isoform X1

Conserved Domains (4) summary

COG5048
Location:421 → 477

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:390 → 408

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:437 → 463

zf-H2C2_2; Zinc-finger double domain

pfam18366
Location:360 → 412

zf_ZIC; Zic proteins zinc finger domain