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    impdh1b IMP (inosine 5'-monophosphate) dehydrogenase 1b [ Danio rerio (zebrafish) ]

    Gene ID: 338306, updated on 9-Dec-2024

    Summary

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    Official Symbol
    impdh1bprovided by ZNC
    Official Full Name
    IMP (inosine 5'-monophosphate) dehydrogenase 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030219-206
    See related
    Ensembl:ENSDARG00000029524 AllianceGenome:ZFIN:ZDB-GENE-030219-206
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    D3; IMPDH1; IMPD 1b; IMPDH 1b; id:ibd5035; wu:fa09h11; wu:fa99c03; zgc:113446; si:dkey-31f5.7
    Summary
    Predicted to enable IMP dehydrogenase activity. Predicted to be involved in GTP biosynthetic process. Predicted to act upstream of or within purine nucleotide biosynthetic process. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; heart; nervous system; notochord; and pigment cell. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to human IMPDH1 (inosine monophosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See impdh1b in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (18960850..18985481)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (18971603..18996505)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene malonyl CoA:ACP acyltransferase (mitochondrial) Neighboring gene RAP1B, member of RAS oncogene family Neighboring gene proline rich transmembrane protein 4b Neighboring gene leptin b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. IMPDH forms the cytoophidium in zebrafish. Keppeke GD, et al. Dev Biol, 2021 Oct. PMID 34048735
    2. Mycophenolic Acid-Induced Developmental Defects in Zebrafish Embryos. Jiang LL, et al. Int J Toxicol, 2016 Nov. PMID 27694306
    3. A highly conserved zebrafish IMPDH retinal isoform produces the majority of guanine and forms dynamic protein filaments in photoreceptor cells. Cleghorn WM, et al. J Biol Chem, 2022 Jan. PMID 34813793, Free PMC Article
    4. Integrative analysis of circadian transcriptome and metabolic network reveals the role of de novo purine synthesis in circadian control of cell cycle. Li Y, et al. PLoS Comput Biol, 2015 Feb. PMID 25714999, Free PMC Article
    5. Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans. Driessen M, et al. Toxicol Lett, 2014 Oct 1. PMID 25064622

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IMPDH forms the cytoophidium in zebrafish.
      Title: IMPDH forms the cytoophidium in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables IMP dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables IMP dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within GMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inosine-5'-monophosphate dehydrogenase 1b
    Names
    IMP (inosine monophosphate) dehydrogenase 1
    inosine 5'-phosphate dehydrogenase 1b
    NP_001014391.1
    XP_005164774.1
    XP_005164775.1
    XP_017210441.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014369.2 → NP_001014391.1  inosine-5'-monophosphate dehydrogenase 1b

      See identical proteins and their annotated locations for NP_001014391.1

      Status: VALIDATED

      Source sequence(s)
      BX649534, CT657866, DN896992, EH434249
      UniProtKB/Swiss-Prot
      Q5RGV1
      UniProtKB/TrEMBL
      A0A8M3ART7
      Related
      ENSDARP00000066974.4, ENSDART00000066975.6
      Conserved Domains (3) summary
      cd00381
      Location:29 → 493
      IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
      cd04602
      Location:115 → 230
      CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
      PTZ00314
      Location:16 → 510
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      18960850..18985481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005164717.5 → XP_005164774.1  inosine-5'-monophosphate dehydrogenase 1b isoform X1

      UniProtKB/TrEMBL
      A0A8M2BC24, A0A8M3ART7
      Conserved Domains (3) summary
      cd00381
      Location:118 → 582
      IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
      cd04602
      Location:204 → 319
      CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
      PTZ00314
      Location:104 → 599
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

    2. XM_005164718.5 → XP_005164775.1  inosine-5'-monophosphate dehydrogenase 1b isoform X2

      UniProtKB/TrEMBL
      A0A8M2BBW1, A0A8M3ART7
      Conserved Domains (3) summary
      cd00381
      Location:93 → 557
      IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
      cd04602
      Location:179 → 294
      CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
      PTZ00314
      Location:80 → 574
      PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

    3. XM_017354952.3 → XP_017210441.1  inosine-5'-monophosphate dehydrogenase 1b isoform X3

      UniProtKB/TrEMBL
      A0A8M3ART7, A0A8M6YXW5, Q5RGV0
      Related
      ENSDARP00000066972.4, ENSDART00000066973.5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RGV1.1 GenPept UniProtKB/Swiss-Prot:Q5RGV1

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