Myo18a myosin XVIIIa [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Myo18aprovided by RGD
Full Name: myosin XVIIIaprovided by RGD
Primary source: RGD:1562698
See related: EnsemblRapid:ENSRNOG00000033101 AllianceGenome:RGD:1562698
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ADP binding activity; ATP binding activity; and actin filament binding activity. Predicted to be involved in several processes, including asymmetric Golgi ribbon formation; canonical NF-kappaB signal transduction; and positive regulation of transport. Predicted to act upstream of or within cellular response to type II interferon. Predicted to be located in several cellular components, including actomyosin; brush border; and trans-Golgi network. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Orthologous to human MYO18A (myosin XVIIIA). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 284.9), Heart (RPKM 211.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 53

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (63152303..63253543)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (62654218..62755465)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (64979770..65080535, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study reports that MRCK and myosin II-related MYO18A linked by the adaptor protein LRAP35a form a functional tripartite complex, which is responsible for the assembly of lamellar actomyosin bundles and of a subnuclear actomyosin network.
Title: A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow.
MyoXVIIIA constitutes a novel receptor for SP-A
Title: Identification of the surfactant protein A receptor 210 as the unconventional myosin 18A.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW534454 (e-PCR)
- UniSTS:246584

RH127729 (e-PCR)
- UniSTS:211039

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ADP binding	IEA Inferred from Electronic Annotation more info
enables ADP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
NOT enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Golgi ribbon formation	ISO Inferred from Sequence Orthology more info
involved_in Golgi vesicle budding	IEA Inferred from Electronic Annotation more info
involved_in Golgi vesicle budding	ISO Inferred from Sequence Orthology more info
involved_in actomyosin structure organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actomyosin structure organization	IEA Inferred from Electronic Annotation more info
involved_in actomyosin structure organization	ISO Inferred from Sequence Orthology more info
involved_in asymmetric Golgi ribbon formation	IEA Inferred from Electronic Annotation more info
involved_in asymmetric Golgi ribbon formation	ISO Inferred from Sequence Orthology more info
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of opsonization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of opsonization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of macrophage activation	IEA Inferred from Electronic Annotation more info
involved_in regulation of macrophage activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in actomyosin	IEA Inferred from Electronic Annotation more info
located_in actomyosin	ISO Inferred from Sequence Orthology more info
located_in brush border	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	IEA Inferred from Electronic Annotation more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: unconventional myosin-XVIIIa

Names: basic salivary proline-rich protein 1-like; basic salivary proline-rich protein 2-like; myosin 18a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001172137.3 → NP_001165608.2 unconventional myosin-XVIIIa isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A6HGZ1

Conserved Domains (3) summary

COG5022
Location:381 → 1905

COG5022; Myosin heavy chain [General function prediction only]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:419 → 1173

MYSc_Myo18; class XVIII myosin, motor domain
NM_001415683.1 → NP_001402612.1 unconventional myosin-XVIIIa isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

63152303..63253543

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269370.1 → XP_063125440.1 unconventional myosin-XVIIIa isoform X21

UniProtKB/TrEMBL

A0A8I6A2X3
XM_063269371.1 → XP_063125441.1 unconventional myosin-XVIIIa isoform X22

Related

ENSRNOP00000077922.2, ENSRNOT00000095502.2
XM_063269373.1 → XP_063125443.1 unconventional myosin-XVIIIa isoform X24
XM_063269374.1 → XP_063125444.1 unconventional myosin-XVIIIa isoform X25
XM_063269376.1 → XP_063125446.1 unconventional myosin-XVIIIa isoform X27
XM_063269372.1 → XP_063125442.1 unconventional myosin-XVIIIa isoform X23

UniProtKB/TrEMBL

A0A0G2JY08

Related

ENSRNOP00000097807.2, ENSRNOT00000100376.2
XM_063269375.1 → XP_063125445.1 unconventional myosin-XVIIIa isoform X26

Related

ENSRNOP00000070473.3, ENSRNOT00000088919.3
XM_039086333.2 → XP_038942261.1 unconventional myosin-XVIIIa isoform X6

UniProtKB/TrEMBL

A0A8I5Y6H7

Conserved Domains (4) summary

COG5022
Location:429 → 1960

COG5022; Myosin heavy chain [General function prediction only]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:467 → 1228

MYSc_Myo18; class XVIII myosin, motor domain

NF033777
Location:1876 → 2073

M_group_A_cterm; M protein C-terminal domain
XM_039086335.2 → XP_038942263.1 unconventional myosin-XVIIIa isoform X8

UniProtKB/TrEMBL

A0A8I5Y6H7

Conserved Domains (4) summary

COG5022
Location:393 → 1924

COG5022; Myosin heavy chain [General function prediction only]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:431 → 1192

MYSc_Myo18; class XVIII myosin, motor domain

NF033777
Location:1840 → 2037

M_group_A_cterm; M protein C-terminal domain
XM_039086337.2 → XP_038942265.1 unconventional myosin-XVIIIa isoform X9

UniProtKB/TrEMBL

A0A8I5Y6H7

Conserved Domains (4) summary

COG5022
Location:381 → 1912

COG5022; Myosin heavy chain [General function prediction only]

cd00992
Location:220 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd01386
Location:419 → 1180

MYSc_Myo18; class XVIII myosin, motor domain

NF033777
Location:1828 → 2025

M_group_A_cterm; M protein C-terminal domain
XM_063269361.1 → XP_063125431.1 unconventional myosin-XVIIIa isoform X10
XM_063269362.1 → XP_063125432.1 unconventional myosin-XVIIIa isoform X11

Related

ENSRNOP00000080654.2, ENSRNOT00000098495.2
XM_063269363.1 → XP_063125433.1 unconventional myosin-XVIIIa isoform X12
XM_063269359.1 → XP_063125429.1 unconventional myosin-XVIIIa isoform X6
XM_039086344.2 → XP_038942272.1 unconventional myosin-XVIIIa isoform X15

UniProtKB/TrEMBL

A0A8I6AAE3

Conserved Domains (3) summary

COG5022
Location:50 → 1581

COG5022; Myosin heavy chain [General function prediction only]

cd01386
Location:88 → 849

MYSc_Myo18; class XVIII myosin, motor domain

NF033777
Location:1497 → 1694

M_group_A_cterm; M protein C-terminal domain
XM_063269365.1 → XP_063125435.1 unconventional myosin-XVIIIa isoform X16
XM_039086340.2 → XP_038942268.1 unconventional myosin-XVIIIa isoform X14

UniProtKB/TrEMBL

A0A8I6AAE3

Conserved Domains (3) summary

COG5022
Location:62 → 1593

COG5022; Myosin heavy chain [General function prediction only]

cd01386
Location:100 → 861

MYSc_Myo18; class XVIII myosin, motor domain

NF033777
Location:1509 → 1706

M_group_A_cterm; M protein C-terminal domain
XM_063269360.1 → XP_063125430.1 unconventional myosin-XVIIIa isoform X7

Related

ENSRNOP00000084388.1, ENSRNOT00000102240.2
XM_063269353.1 → XP_063125423.1 unconventional myosin-XVIIIa isoform X1
XM_063269354.1 → XP_063125424.1 unconventional myosin-XVIIIa isoform X2
XM_063269358.1 → XP_063125428.1 unconventional myosin-XVIIIa isoform X5
XM_063269355.1 → XP_063125425.1 unconventional myosin-XVIIIa isoform X3
XM_063269357.1 → XP_063125427.1 unconventional myosin-XVIIIa isoform X4
XM_063269364.1 → XP_063125434.1 unconventional myosin-XVIIIa isoform X13
XM_063269366.1 → XP_063125436.1 unconventional myosin-XVIIIa isoform X17
XM_063269367.1 → XP_063125437.1 unconventional myosin-XVIIIa isoform X18
XM_063269368.1 → XP_063125438.1 unconventional myosin-XVIIIa isoform X19
XM_063269369.1 → XP_063125439.1 unconventional myosin-XVIIIa isoform X20
XM_063269377.1 → XP_063125447.1 unconventional myosin-XVIIIa isoform X28