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    Lsamp limbic system-associated membrane protein [ Mus musculus (house mouse) ]

    Gene ID: 268890, updated on 27-Nov-2024

    Summary

    Official Symbol
    Lsampprovided by MGI
    Official Full Name
    limbic system-associated membrane proteinprovided by MGI
    Primary source
    MGI:MGI:1261760
    See related
    Ensembl:ENSMUSG00000061080 Ensembl:ENSMUSG00000121926 AllianceGenome:MGI:1261760
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lam; Lamp; Gm29907; 5430428I19; B130007O04Rik; D930023J12Rik
    Summary
    Acts upstream of or within locomotory exploration behavior. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human LSAMP (limbic system associated membrane protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 15.7), cortex adult (RPKM 9.4) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Lsamp in Genome Data Viewer
    Location:
    16; 16 B4
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (39804674..42002042)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (39984254..42181679)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53954 Neighboring gene predicted gene, 36903 Neighboring gene STARR-seq mESC enhancer starr_40842 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 53260 Neighboring gene predicted gene, 22543 Neighboring gene STARR-seq mESC enhancer starr_40843 Neighboring gene zinc finger protein 777 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40844 Neighboring gene STARR-seq mESC enhancer starr_40845 Neighboring gene STARR-seq mESC enhancer starr_40846 Neighboring gene STARR-seq mESC enhancer starr_40847 Neighboring gene predicted gene, 52230 Neighboring gene STARR-seq mESC enhancer starr_40848 Neighboring gene STARR-seq mESC enhancer starr_40849 Neighboring gene STARR-seq mESC enhancer starr_40850 Neighboring gene STARR-seq mESC enhancer starr_40851 Neighboring gene STARR-seq mESC enhancer starr_40852 Neighboring gene STARR-seq mESC enhancer starr_40853 Neighboring gene STARR-seq mESC enhancer starr_40854 Neighboring gene STARR-seq mESC enhancer starr_40855 Neighboring gene predicted gene, 53955 Neighboring gene STARR-seq mESC enhancer starr_40856 Neighboring gene predicted gene, 53259 Neighboring gene STARR-seq mESC enhancer starr_40857 Neighboring gene STARR-seq mESC enhancer starr_40858 Neighboring gene predicted gene, 46551 Neighboring gene STARR-seq mESC enhancer starr_40859 Neighboring gene predicted gene, 52229 Neighboring gene STARR-seq mESC enhancer starr_40861 Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene microRNA 6540 Neighboring gene growth associated protein 43

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within locomotory exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    limbic system-associated membrane protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347236.2NP_001334165.1  limbic system-associated membrane protein isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102503, AC122207, AC124565, AC154341, AC163665
      Consensus CDS
      CCDS84234.1
      UniProtKB/Swiss-Prot
      Q8BLK3
      UniProtKB/TrEMBL
      Q3TYE5
      Related
      ENSMUSP00000097349.4, ENSMUST00000099761.10
      Conserved Domains (2) summary
      pfam13927
      Location:219294
      Ig_3; Immunoglobulin domain
      cl11960
      Location:38128
      Ig; Immunoglobulin domain
    2. NM_001361281.2NP_001348210.1  limbic system-associated membrane protein isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102503, AC116106, AC122207, AC124565, AC131108, AC154341, AC163665
      Consensus CDS
      CCDS88928.1
      UniProtKB/TrEMBL
      A0A087WP80
      Related
      ENSMUSP00000160045.1, ENSMUST00000249949.1
      Conserved Domains (2) summary
      pfam13927
      Location:236311
      Ig_3; Immunoglobulin domain
      cl11960
      Location:55145
      Ig; Immunoglobulin domain
    3. NM_001361282.2NP_001348211.1  limbic system-associated membrane protein isoform 4 precursor

      Status: VALIDATED

      Source sequence(s)
      AC102503, AC116106, AC122207, AC124565, AC131108, AC154341, AC163665
      Conserved Domains (2) summary
      pfam13927
      Location:236311
      Ig_3; Immunoglobulin domain
      cl11960
      Location:55145
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      39804674..42002042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159957.1XP_036015850.1  limbic system-associated membrane protein isoform X4

      UniProtKB/Swiss-Prot
      Q8BLK3
      Conserved Domains (3) summary
      pfam13927
      Location:249325
      Ig_3; Immunoglobulin domain
      cd00096
      Location:266270
      Ig; Ig strand B [structural motif]
      cl11960
      Location:69159
      Ig; Immunoglobulin domain
    2. XM_030249137.2XP_030104997.1  limbic system-associated membrane protein isoform X1

      Conserved Domains (2) summary
      pfam13927
      Location:250325
      Ig_3; Immunoglobulin domain
      cl11960
      Location:69159
      Ig; Immunoglobulin domain
    3. XM_036159956.1XP_036015849.1  limbic system-associated membrane protein isoform X2

      Conserved Domains (3) summary
      pfam13927
      Location:249325
      Ig_3; Immunoglobulin domain
      cd00096
      Location:266270
      Ig; Ig strand B [structural motif]
      cl11960
      Location:69159
      Ig; Immunoglobulin domain
    4. XM_030249138.2XP_030104998.1  limbic system-associated membrane protein isoform X3

      Conserved Domains (2) summary
      pfam13927
      Location:250325
      Ig_3; Immunoglobulin domain
      cl11960
      Location:69159
      Ig; Immunoglobulin domain
    5. XM_006522201.4XP_006522264.2  limbic system-associated membrane protein isoform X5

      UniProtKB/Swiss-Prot
      Q8BLK3
      Conserved Domains (2) summary
      pfam13927
      Location:211286
      Ig_3; Immunoglobulin domain
      cl11960
      Location:30120
      Ig; Immunoglobulin domain
    6. XM_036159958.1XP_036015851.1  limbic system-associated membrane protein isoform X6

      UniProtKB/Swiss-Prot
      Q8BLK3
      Conserved Domains (3) summary
      pfam13927
      Location:210286
      Ig_3; Immunoglobulin domain
      cd00096
      Location:227231
      Ig; Ig strand B [structural motif]
      cl11960
      Location:30120
      Ig; Immunoglobulin domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175548.3: Suppressed sequence

      Description
      NM_175548.3: This RefSeq has been removed because currently there is insufficient support for the transcript and protein.