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    HAB1 HYPERSENSITIVE TO ABA1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843609, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HAB1
    Official Full Name
    HYPERSENSITIVE TO ABA1
    Primary source
    TAIR:AT1G72770
    Locus tag
    AT1G72770
    See related
    Araport:AT1G72770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtHAB1; F28P22.4; F28P22_4; homology to ABI1; HYPERSENSITIVE TO ABA1
    Summary
    mutant has ABA hypersensitive inhibition of seed germination; Protein Phosphatase 2C; regulates the activation of the Snf1-related kinase OST1 by abscisic acid.
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    Genomic context

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    See HAB1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (27389948..27393327)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene translocase inner membrane subunit 23-2 Neighboring gene Protein kinase superfamily protein Neighboring gene tRNA-Ser Neighboring gene hydroxyproline-rich glycoprotein family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ABA signalling is fine-tuned by antagonistic HAB1 variants. Wang Z, et al. Nat Commun, 2015 Sep 25. PMID 26419884
    2. A hypermorphic mutation in the protein phosphatase 2C HAB1 strongly affects ABA signaling in Arabidopsis. Robert N, et al. FEBS Lett, 2006 Aug 21. PMID 16876791
    3. Enhancement of abscisic acid sensitivity and reduction of water consumption in Arabidopsis by combined inactivation of the protein phosphatases type 2C ABI1 and HAB1. Saez A, et al. Plant Physiol, 2006 Aug. PMID 16798945, Free PMC Article
    4. Agrochemical control of plant water use using engineered abscisic acid receptors. Park SY, et al. Nature, 2015 Apr 23. PMID 25652827
    5. H2O2 inhibits ABA-signaling protein phosphatase HAB1. Sridharamurthy M, et al. PLoS One, 2014. PMID 25460914, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Recruitment of HAB1 and SnRK2.2 by C2-domain protein CAR1 in plasma membrane ABA signaling.
      Title: Recruitment of HAB1 and SnRK2.2 by C2-domain protein CAR1 in plasma membrane ABA signaling.
    2. Molecular dynamics simulations have been applied to two different PYL10-HAB1 complex heterodimer systems representing normal and magnesium deficient conditions. The heterodimer conformation and stability were delineated at high temperatures mimicking heat stress. Results showed that the thermostability of the heat stress response heterodimer was significantly dependent on the magnesium.
      Title: Thermostability of the PYL-PP2C Heterodimer Is Dependent on Magnesium: In Silico Insights into the Link between Heat Stress Response and Magnesium Deficiency in Plants.
    3. HAB1.1 and HAB1.2, that play opposing roles in abscisic acid -mediated seed germination and ABA-mediated post-germination. developmental arrest.
      Title: ABA signalling is fine-tuned by antagonistic HAB1 variants.
    4. We have identified HAB1 C186 and C274 as H2O2-sensitive thiols and demonstrate that their oxidation inhibits both HAB1 catalytic activity and its ability to physically associate with SnRK2.6 by formation of intermolecular dimers.
      Title: H2O2 inhibits ABA-signaling protein phosphatase HAB1.
    5. The transgenic plants show an acute abscisic acid (ABA) insensitivity, demonstrating the importance of ABA-mediated PYR/PYL/RCAR-PP2C contacts for receptor function in vivo.
      Title: Modulation of abscisic acid signaling in vivo by an engineered receptor-insensitive protein phosphatase type 2C allele.
    6. Data indicate that PYL8 interacted in vivo with at least five PP2Cs, namely HAB1, HAB2, ABI1, ABI2, and PP2CA.
      Title: PYRABACTIN RESISTANCE1-LIKE8 plays an important role for the regulation of abscisic acid signaling in root.
    7. study reports a SnRK2-PP2C complex structure, which reveals marked similarity in PP2C recognition by SnRK2 and ABA receptors; structural results provide a simple mechanism that directly couples ABA binding to SnRK2 kinase activation
      Title: Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases.
    8. Data demonstrated that HAB1 dephosphorylates and deactivates OST1 in vitro. HAB1 and the related PP2Cs ABI1 and ABI2 interact with OST1 in vivo, and mutations in the corresponding genes strongly affect OST1 activation by ABA.
      Title: Protein phosphatases 2C regulate the activation of the Snf1-related kinase OST1 by abscisic acid in Arabidopsis.
    9. PYL5 binds ABA with micromolar or nanomolar affinity in the absence or presence of HAB1, respectively.
      Title: Modulation of drought resistance by the abscisic acid receptor PYL5 through inhibition of clade A PP2Cs.
    10. findings show that abscissic binds to PYRABACTIN RESISTANCE 1 (PYR1), which in turn binds to and inhibits Type 2C protein phosphatases (HAB1)
      Title: Abscisic acid inhibits type 2C protein phosphatases via the PYR/PYL family of START proteins.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    NM_001198456.1
    NM_001334550.1
    NM_001334551.1
    NM_105936.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    HYPERSENSITIVE TO ABA1
    NP_001077815.1
    • homology to ABI1 (HAB1); FUNCTIONS IN: protein serine/threonine phosphatase activity; INVOLVED IN: protein amino acid dephosphorylation; LOCATED IN: protein serine/threonine phosphatase complex; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein phosphatase 2C, manganese/magnesium aspartate binding site (InterPro:IPR000222), Protein phosphatase 2C-related (InterPro:IPR001932), Protein phosphatase 2C (InterPro:IPR015655), Protein phosphatase 2C, N-terminal (InterPro:IPR014045); BEST Arabidopsis thaliana protein match is: homology to ABI2 (TAIR:AT1G17550.1); Has 5185 Blast hits to 5183 proteins in 297 species: Archae - 2; Bacteria - 12; Metazoa - 1329; Fungi - 515; Plants - 2267; Viruses - 4; Other Eukaryotes - 1056 (source: NCBI BLink).
    NP_001185385.1
    • homology to ABI1 (HAB1); FUNCTIONS IN: protein serine/threonine phosphatase activity; INVOLVED IN: protein amino acid dephosphorylation; LOCATED IN: protein serine/threonine phosphatase complex; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein phosphatase 2C, manganese/magnesium aspartate binding site (InterPro:IPR000222), Protein phosphatase 2C-related (InterPro:IPR001932), Protein phosphatase 2C (InterPro:IPR015655), Protein phosphatase 2C, N-terminal (InterPro:IPR014045); BEST Arabidopsis thaliana protein match is: homology to ABI2 (TAIR:AT1G17550.1).
    NP_177421.1
    • homology to ABI1 (HAB1); FUNCTIONS IN: protein serine/threonine phosphatase activity; INVOLVED IN: protein amino acid dephosphorylation; LOCATED IN: protein serine/threonine phosphatase complex; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein phosphatase 2C, manganese/magnesium aspartate binding site (InterPro:IPR000222), Protein phosphatase 2C-related (InterPro:IPR001932), Protein phosphatase 2C, N-terminal (InterPro:IPR014045), Protein phosphatase 2C (InterPro:IPR015655); BEST Arabidopsis thaliana protein match is: homology to ABI2 (TAIR:AT1G17550.1); Has 6788 Blast hits to 6778 proteins in 499 species: Archae - 4; Bacteria - 382; Metazoa - 1655; Fungi - 745; Plants - 2728; Viruses - 7; Other Eukaryotes - 1267 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      27389948..27393327
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001084346.3 → NP_001077815.1  HYPERSENSITIVE TO ABA1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077815.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WNL4
      Conserved Domains (1) summary
      smart00332
      Location:180 → 406
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain

    2. NM_105936.4 → NP_177421.1  HYPERSENSITIVE TO ABA1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177421.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z251, O81709, Q0WLM7, Q9CAJ0
      UniProtKB/TrEMBL
      A0A5S9WTV1, A0A654ENG3
      Conserved Domains (1) summary
      smart00332
      Location:180 → 499
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain

    3. NM_001334550.1 → NP_001320804.1  HYPERSENSITIVE TO ABA1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z251, O81709, Q0WLM7, Q9CAJ0
      UniProtKB/TrEMBL
      A0A5S9WTV1, A0A654ENG3
      Conserved Domains (1) summary
      smart00332
      Location:180 → 499
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain

    4. NM_001334551.1 → NP_001320805.1  HYPERSENSITIVE TO ABA1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WNL4
      Conserved Domains (1) summary
      smart00332
      Location:180 → 406
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain

    5. NM_001198456.1 → NP_001185385.1  HYPERSENSITIVE TO ABA1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185385.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z251, O81709, Q0WLM7, Q9CAJ0
      UniProtKB/TrEMBL
      A0A5S9WTV1, A0A654ENG3
      Conserved Domains (1) summary
      smart00332
      Location:180 → 499
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CAJ0.1

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