xnf7.L Nuclear factor 7 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: xnf7.L
Official Full Name: Nuclear factor 7 L homeolog
Primary source: Xenbase:XB-GENE-6252335
Locus tag: XELAEV_18001532mg
See related: EnsemblRapid:ENSXLAG00005019394 AllianceGenome:Xenbase:XB-GENE-6252335
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: xnf7; xnf7-a; xnf7-o
Summary: Predicted to enable DNA binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to act upstream of or within protein ubiquitination and regulation of DNA-templated transcription. Predicted to be located in cytoplasm and nucleus. Is expressed in ectoderm; musculoskeletal system; and nervous system. [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 9_10L

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10L	NC_054387.1 (132644612..132657284)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016694813.1 (3508426..3521098, complement)

Chromosome 9_10L - NC_054387.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Xnf7 is an APC inhibitor able to link spindle status to the APC through direct association with APC core components.
Title: Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase.
Xnf7 is a nuclear MAP whose microtubule-bundling activity, but not E3-ligase activity, contributes to microtubule organization and spindle integrity.
Title: Xnf7 contributes to spindle integrity through its microtubule-bundling activity.
Interaction of NF7 with active transcriptional units of RNA polymerase II is mediated by a trimeric B box.
Title: The tripartite motif of nuclear factor 7 is required for its association with transcriptional units.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear factor 7, brain

Names: xNF7-B; zinc finger nuclear phosphoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088004.1 → NP_001081473.1 nuclear factor 7, brain

See identical proteins and their annotated locations for NP_001081473.1

Status: PROVISIONAL

Source sequence(s)

S64515

UniProtKB/Swiss-Prot

Q92021

UniProtKB/TrEMBL

A9JS19

Related

ENSXLAP00005057006.1, ENSXLAT00005058338.1

Conserved Domains (5) summary

cd00021
Location:223 → 260

BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.

pfam11717
Location:20 → 76

Tudor-knot; RNA binding activity-knot of a chromodomain

pfam15227
Location:145 → 184

zf-C3HC4_4; zinc finger of C3HC4-type, RING

cd13733
Location:436 → 604

SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

cl23765
Location:273 → 393

iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits