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    LOC127824581 OCT4-NANOG hESC enhancer GRCh37_chr12:75770264-75770835 [ Homo sapiens (human) ]

    Gene ID: 127824581, updated on 12-Sep-2024

    Summary

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    Gene symbol
    LOC127824581
    Gene description
    OCT4-NANOG hESC enhancer GRCh37_chr12:75770264-75770835
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors. [provided by RefSeq, Nov 2022]
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    Genomic context

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    See LOC127824581 in Genome Data Viewer
    Location:
    chromosome: 12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (75376484..75377055)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (75351073..75351644)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (75770264..75770835)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene calcyphosine 2 Neighboring gene necdin, MAGE family member pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4661 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75734995-75735496 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75735497-75735996 Neighboring gene GLIPR1 like 1 Neighboring gene uncharacterized LOC124902968 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:75784671-75784843 Neighboring gene GLIPR1 like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4662 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75880921-75881422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:75881423-75881922 Neighboring gene GLIPR1 antisense RNA 1 Neighboring gene GLI pathogenesis related 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_126097.1 

      Range
      101..672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      75376484..75377055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      75351073..75351644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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